@Fromme_Lab

We study how cells sort important stuff around their insides and to their outsides | Golgi aficionados | @Cornell & @CornellMBG | Tweets by lab members

 Cornell University
fromme.wicmb.cornell.edu/
Joined October 2021
  • Tweets162
  • Following651
  • Followers875
29Media
Really proud of this paper just out in JCB. At almost every turn, SURF4 surprised us. Amazing PhD student, @jmaldutyte, sleuthed it out. rupress.org/jcb/article/224/…

ER export via SURF4 uses diverse mechanisms of both client and coat engagement

Traffic of soluble secretory proteins from the endoplasmic reticulum by the export receptor, SURF4, is remarkably complex. Different cargoes use distinct m

rupress.org
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Columbia will award the 2024 Louisa Gross Horwitz Prize to Scott Emr and Wesley Sundquist for discovering the ESCRT pathway and revealing how it works. Read more: columbiamed.link/47uD4jS
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Excited to announce an MBG faculty search for two assistant professor positions in collaboration with the Weill Institute for Cell and Molecular Biology, @weillinstitute. Please share and apply! academicjobsonline.org/ajo/j…
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New preprint. More on non-canonical motifs for DDR kinases. Here we find that Tel1 (yeast ATM) targets D/E-S/T. ... more prevalent than S/T-Q ... NOT shared with Mec1. May explain how Tel1 plays specialized roles in DNA repair and telomere maintenance. biorxiv.org/content/10.1101/…
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Final version of our latest Kramer story is out! Congrats to @Hongyan_S for leading this effort & Adnan, Dylan, Alessandro, & @nicobuchon too! Read on to learn how Wnt signaling in surprisingly many cell types promotes stem cell proliferation in the gut: sciencedirect.com/science/ar…
Jeremy Baskin@basktastic22 Feb 2023
New preprint: It's about a gene called Kramer 😉 that controls #WntSignaling & stem cell proliferation in the fruit fly intestine. Congrats to @Hongyan_S @weillinstitute & @nicobuchon @cornellento @cihmid! cc: @SeinfeldTV @Seinfeld2000 @JerrySeinfeld doi.org/10.1101/2023.02.21.5… 1/n
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Happy to share the newest preprint from @HollopeterLab @cornellvet: biorxiv.org/cgi/content/shor…. We propose the Inversin complex works via a dimerization mechanism. You’re probably thinking, “What the $%@! is the Inversin complex?” Let me explain:
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I'm so excited to finally share the results of my PhD work! Check out this thread for all of the highlights! Ric1-Rgp1-Rab6 has been the most difficult #cryoEM project I've worked on so far, but I'm so happy with how it came together and what we learned about Rab6 activation!
Fromme Lab@Fromme_Lab7 May 2024
We are excited to share a new preprint from the lab! Rab6 is a central regulator of the Golgi, important for trafficking and autophagy. @FeathersRyan used #cryoEM to determine the structural basis of the Rab6 activation process. (1/9)
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Fromme Lab retweeted
Roeder lab@RoederLab5 May 2024
We created a new technology to examine plant transmembrane proteins: Plant Membrane-On-A-Chip. pubs.acs.org/doi/10.1021/acs…

Plant Membrane-On-A-Chip: A Platform for Studying Plant Membrane Proteins and Lipids

Abstract. The cell plasma membrane is a two-dimensional, fluid mosaic material composed of lipids and proteins that create a semipermeable barrier defining

pubs.acs.org
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Happy Golgi Day
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We have postdoctoral positions open (see ad below). Projects involve DNA damage signaling mechanisms and development of novel approaches to interrogate kinase/phosphatase action in cells. Come join our lab! Please share / apply.
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A Highlight from the MBoC Journal @KaitlynManzer & @Fromme_Lab examine the localization of the GTPase Arf1—& its inactivating GAPs—during Golgi maturation. The team found the GAP Age2 is recruited to the Golgi membrane thru its unique amphipathic helix. molbiolcell.org/doi/10.1091/…
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🚨 Awesome alumnus alert 🚨 Superstar @Fromme_Lab alum (@CornellMBG) @aaronjoinerphd is featured in the @UCBerkeley @UCB_MillerInst newsletter! #proudofalumni miller.berkeley.edu/images/n…
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🚨We are beyond thrilled to announce the inaugural class of Weill Institute Emerging Scholars! 🎉 We can't wait for these 8 exceptional graduate students to visit Cornell & share their research in Oct 2023! Info & details: news.cornell.edu/stories/202… tinyurl.com/WICMBScholars 1/n 👇
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Pumped for @KaitlynManzer’s B exam today on the spatiotemporal regulation of a central player in Golgi complex function, Arf1! Congrats to newly minted Dr. Manzer!! @Fromme_Lab @jcfromme @CornellMBG
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Congratulations to graduate student Jumana Badar in the lab for receiving the Harry and Samuel Mann Outstanding Graduate Student Award. gradschool.cornell.edu/annou… Jumana's work is focused on signaling mechanisms that control the restart of stalled DNA replication forks.
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Big congrats to all PhD graduates from @CornellMBG ! Thanks @jcfromme for hosting the ceremony!
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🚨 New paper in @NatureChemistry from @ReikaTei in the @basktastic lab on development of "membrane editors" for precise modification of cellular lipids—another successful @weillinstitute collaboration, w/key contributions from @SaketBagde @Fromme_Lab! @CornellChem @CornellMBG 👇
Reika Tei@ReikaTei22 May 2023
Our work about superPLD is now published! In this paper, we describe how we can harness mammalian cell-based directed evolution to engineer a membrane editor (phospholipase D; PLD) with superior performance in mammalian cells. 1/n nature.com/articles/s41557-0…
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Happy Mother's Day to the @weillinstitute mother goose!
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This year's Northeast Regional Yeast Meeting registration is up 🍺🧬: blogs.cornell.edu/gibneylab/…
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Here's an over engineered but easy to use solution for the Bash averse who want to modify RELION star files. #CryoEM
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