@FreemanLabOMRF

Neuroepigenetics lab examining brain and retinal aging

 OMRF, OKC, USA
freemanlab.omrf.org/
Joined January 2022
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Study brain aging? Using a tamoxifen inducible cre model and want to TAM treat at an old age? Should work great. Check out our validation study: pubmed.ncbi.nlm.nih.gov/3805…

Specificity and efficiency of tamoxifen-mediated Cre induction is equivalent regardless of age -...

Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (<2 m.o.) Tam induction, but...

pubmed.ncbi.nlm.nih.gov
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Our new work examining cell type-specific DNA modification patterns in the brain demonstrates the importance of differentiating between mC and hmC in neuroepigenomic analyses. epigeneticsandchromatin.biom…

Differential usage of DNA modifications in neurons, astrocytes, and microglia

Epigenetics & Chromatin - Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to isolate...

link.springer.com
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Check out our new work in conjunction #OcanasLab with on sex divergences in microglia phenotypes and senescence with aging. jneuroinflammation.biomedcen…

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocamp...

Journal of Neuroinflammation - Microglia, the brain’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more...

link.springer.com
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Excited that our work on microglial MHC-I with aging and Alzheimer's is now published. Congratulations to Collyn Kellogg on his first paper as a 1st author! pubmed.ncbi.nlm.nih.gov/3739…

Microglial MHC-I induction with aging and Alzheimer's is conserved in mouse models and humans -...

Major histocompatibility complex I (MHC-I) CNS cellular localization and function is still being determined after previously being thought to be absent from the brain. MHC-I expression has been...

pubmed.ncbi.nlm.nih.gov
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NIA/NIH F99-K00 award for Victor Ansere from the FreemanLab @OMRF. This will support Victor's graduate work in plasma transfer treatments for aging and subsequent post-doc. Innovative award transition training award from @NIHAging. Congratulations to Victor!
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Big day & massive congratulations to @OcanasSR from our group. She is an NIH Early Independence Awardee @NIH_CommonFund #NIHHighRisk. 1st award of this type in Oklahoma. We look forward to Sarah and her group being part of Genes & Human Disease Program at @OMRF.
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Dr. Freeman has been received a Biomedical Laboratory Research and Development VA Research Career Scientist Award. @VAResearch is a critical funder of biomedical research to improve the lives of our nation's Veterans and all Americans.
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In this #eNeuro study, @OcanasSR et al.@FreemanLabOMRF analyzed tissue dissociation & microglial sorting techniques in terms of yield, purity, & activational confounds to provide recommendations for optimal microglial isolation based on experimental needs. eneuro.org/lookup/DOI/10.152…
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Congratulations to PhD student Sarah Ocanas in the lab on her new publication - eneuro.org/content/early/202…. A deep investigation of isolating microglia without causing artifacts.
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Excited for support from #ImpetusGrants to push forward our understanding of epigenetic clocks
OMRF@OMRF27 Jan 2022
OMRF scientists Dr. Bill Freeman and Dr. Benjamin Miller recently received Impetus Grants to pursue bold ideas in #AgingBiology. omrf.org/2022/01/27/new-fund…
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