Spatial Biology | Postdoc in the Kristensen group at Aarhus University | PhD @labs_mann @UCPH_CPR | Former labs: @IFink_Lab @lehtiolab @steen_lab
Aarhus, Denmark
Joined March 2014
- Tweets238
- Following431
- Followers338
- Likes2.6K
Pinned Tweet
Happy to share our assessment of colon organoids and the effect of xenotransplantation! We pushed the limits of Deep Visual Proteomics - generating a spatial proteomic resource of the human colon, down to the single-cell level.
Out now in @CellSystemsCP: Deep Visual Proteomics shows xenotransplantation drives colon #organoids toward in-vivo-like proteomes supporting their use in regenerative medicine; culture tweaks can mimic this shift. With @JensenLab_UCPH. Frederik Post @Freddyomics explains further:
Frederik Post retweeted
Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination.
cell.com/cancer-cell/fulltex…
Frederik Post retweeted
Our paper is out in @Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
nature.com/articles/s41586-0…
Frederik Post retweeted
Thrilled to share our latest work published in @NatureGenet today: Plasma proteome variation and its genetic determinants in children and adolescents. 🩸#PediatricProteomics #PlasmaProteomics #pQTL
nature.com/articles/s41588-0…
🧵A thread by @hustniu explains below ⬇️
Frederik Post retweeted
Our @Nature_NPJ npj Precision Oncology paper reveals how Deep Visual Proteomics maps protein networks across multiple organs in Signet Ring Cell Carcinoma, offering new perspectives on tumor evolution - one patient, four organs, many insights!
rdcu.be/d8KyK
Frederik Post retweeted
Proud to share our work on mipDVP, now online in @MolecularCell! It’s been an incredible journey working with a fantastic team to uncover new insights into tumor microenvironments.
@UCPH_CPR @novonordiskfond @labs_mann @miltenyibiotec @thermofisher @bruker @LeicaMicro
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell
doi.org/10.1016/j.molcel.202…
Frederik Post retweeted
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell
doi.org/10.1016/j.molcel.202…
Frederik Post retweeted
Online Now: Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics dlvr.it/THM62z
Frederik Post retweeted
News from the @labs_mann in @MolecularCell: Multiplexed imaging-powered Deep Visual Proteomics offers deeper insights into the tumor microenvironment by mapping 21 cell populations and quantifying thousands of proteins in each, revealing critical tumor-immune interactions. Huge Kudos to Xiang @_GNAI_X for his hard work and dedication! #DVP #mipDVP
Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell
doi.org/10.1016/j.molcel.202…
Frederik Post retweeted
Deep visual proteomics, a spatial omics technique that has already been shown to save lives, here applied to unraveling the crosstalk between immune cells and proteins in cancer tissue
cell.com/molecular-cell/full… @MolecularCell @labs_mann @MundAndreas
Frederik Post retweeted
Thrilled to share that our Zorya paper is now published online in Nature! It was an incredible team effort @__jphilipp @Salmo_Lab @SimonJacksonNZ —thank you to everyone who contributed to this work.@IngaTrails @VKleinSousa @AritzRoa @freddie__martin @yongwangKU @AHarms485 @others
Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni nature.com/articles/s41586-0…
Frederik Post retweeted
Thrilled to see spatial proteomics as @NatureMethods Method of the Year 2024! As pioneers of Deep Visual Proteomics (DVP), we're excited to help map the spatial proteome at unprecedented depth #MethodOfTheYear #SpatialProteomics #DeepVisualProteomics
It was an absolute dream to help with this Method of the Year! SPATIAL PROTEOMICS gets a well-deserved spotlight! Thanks so much to all the authors who contributed their comments! @RongFan8 @BodenmillerLab @leeat_keren @labs_mann @DanielaQuail
Frederik Post retweeted
Exciting news - Spatial Proteomics is @naturemethods’ 2024 Method of the Year! Our commentary highlights how Deep Visual Proteomics (DVP) unites imaging, data science & high-res proteomics at single-cell resolution, fueling predictive tissue models and personalized medicine. Stay tuned! #DVP #SpatialProteomics #SpatialMedicine @UCPH_CPR @MPI_Biochem @novonordiskfond
The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳
For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.
nature.com/articles/s41592-0…
Frederik Post retweeted
The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳
For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread.
nature.com/articles/s41592-0…
Frederik Post retweeted
The 68th Benzon Symposium report is now online in @molcellprot ! Fantastic conference that brought together top global experts in Copenhagen to translate proteomics to the clinics - from technological advances to regulatory frameworks!
@labs_mann
bit.ly/3AsuN3X
Frederik Post retweeted
AATD affects thousands, causing liver & lung disease via protein aggregation. Our new preprint used #DeepVisualProteomics to study liver cells and reveals key AATD insights with clinical implications . Video and tweetorial @metaboflo #Alpha1Awareness
bit.ly/4hzl64o
Frederik Post retweeted
The Dawn of Spatial Medicine
Until now, spatial omics was used to understand human biology. That changed when it saved lives of patients with a fatal skin condition.
In the new Ground Truths, pioneering work by @labs_mann @NordmannThierry @MPI_Biochem and an international consortium
Link in my profile
Did my Twitter handle break speech-to-text algorithms? 😂 @neely615 @ProteomicsNews
Frederik Post retweeted
If you are at #hupo2024 in Dresden, do catch up with our lab-mates to know more about some of our exciting research in @labs_mann
👇
