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ALT Research context Insulin dosing in T1D is a challenging task: in female individuals with T1D, this task may be further complicated by hormonal fluctuations, e.g., across the menstrual cycle Studies investigating the impact of the menstrual cycle on glucose control report variations in glucose metabolism and quality of glycemic control across the menstrual cycle, in at least a proportion of premenopausal females with T1D Despite non-negligible inter-subject variability, the most common pattern of glucose metabolism changes across the menstrual cycle is characterized by: ⚫ increased insulin sensitivity during the follicular phase, with increased risk of menstrual hypoglycemia ⚫ decreased insulin sensitivity during the luteal phase, with increased exposure to premenstrual hyperglycemia To mitigate the impact of cycle-related insulin sensitivity variability on the quality of glycemic control, accurate planning of insulin therapy is needed, wit




































