Bioinformatics & Computational Biology @ University College London @ISMBInstitute @ucl
London, England
Joined March 2018
- Tweets129
- Following66
- Followers177
- Likes28
Pinned Tweet
New paper alert! 🚨
sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics.
nature.com/articles/s41592-0…
Belated announcement that ImmunoMatch has now been published in @naturemethods !🎉 AI powered prediction of antibody heavy-light chain pairing with applications in understanding B cell biology and mAb discovery. nature.com/articles/s41592-0…
Also check out UCL press release: ucl.ac.uk/life-sciences/news…
Great talks by both Oriol and Joseph at #ELIXIR #3dBioinfo meeting at Barcelona!
Fraternali Lab retweeted
Another preprint @FraternaliLab: We explored how the antibody framework (i.e. parts of variable region away from Ab-Ag interface) can be exploited to fine-tune antibody effector functions. V enjoyable in vitro/in silico collab @ffrancafrat @SophiaKaragiann biorxiv.org/content/10.1101/…
🚨 New preprint on our new approach (IndeLLM) to score pathogenicity of insertions/deletions biorxiv.org/content/10.1101/…
Fraternali Lab retweeted
Happy to share new work @FraternaliLab led by @Dongjun_Guo - exploring how antibody heavy and light chains form specific pairs. We fine-tuned an antibody language model to predict pairing, and asked how pairing propensities change during B cell maturation and in diseases.
Joseph on sciCSR to study and infer class switching dynamics in B cells using scRNA-seq data #ISMB2024
Dongjun's talk on ImmunoMatch a.k.a. antibody "tinder" to study heavy and light chain pairing at 3DSIG! #ISMB2024
Oriol's talk on addressing biases in variant impact prediction at VarI #ISMB2024
Fraternali Lab retweeted
Congratulations to Guillem for winning a prize for his poster on double negative/atypical memory B cells in SARS-CoV-2 mRNA vaccination at the @iit_ucl symposium 2024 🎉👏
Fraternali Lab retweeted
We present VCAb, a new web interface for performing different structure-based explorations towards aspects of antibody engineering: 🧵(1/7)
📄biorxiv.org/content/10.1101/…
🌐fraternalilab.cs.ucl.ac.uk/V…
Fraternali Lab retweeted
Postdoc available in our lab. B cells, antibodies and class switching. Part of a wider BBSRC sLoLa with @FraternaliLab @Mauri_group jobs.surrey.ac.uk/Vacancy.as…
Fraternali Lab retweeted
Well done to Izzy for winning a prize for her presentation on the single cell analysis of B cells in lung cancer!!👏🫁🧬#WIRM – at Davos, Switzerland
Xmas gift 🎁 came early for us: New review came out on @COSB_CRSB where we talked about structures of different antibody isotypes & how to model and study them! Feat. a great deal of fun drawing antibodies in the style of ladders and snakes! Free access at
authors.elsevier.com/c/1iHZn…
Xmas outing feat. a walk across Hertfordshire countryside on a cold wintery day followed by pub! – at Hitchin, England
Fraternali Lab retweeted
Very proud to finally see this recent work from my lab out in Nature Methods!
Thanks to a fantastic collaborator like @JosefNg1 and an enthusiastic group of Immunologists!
nature.com/articles/s41592-0…
Fraternali Lab retweeted
Very happy that sciCSR - our new method in analysing B cell Class-Switch Recombination (CSR) in #scrnaseq data - is out @naturemethods - Tweetorial below 🧵
sciCSR developed by @FraternaliLab, @JosefNg1 and colleagues is a computational workflow that uses scRNA-seq data to predict class switch recombination events and B cell dynamics.
nature.com/articles/s41592-0…