
Scientist fascinated by how noncoding RNAs impact biomedicine. Energy from family&friends. Love #noncodingRNA, believe in #RNAtherapy, live in @CIMA_unav
Joined May 2021
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The deaths of two children in separate gene-editing trials in China raise serious questions about oversight and could have a profound effect on the country’s biomedical industry
go.nature.com/4xbyXUU
Puri Fortes retweeted
A few months ago I was browsing google images looking at p53 western blots in the SK-OV-3 cell line for an unrelated project. I noticed an unusual western blot hosted on Thermo Fisher's website which I posted on social media. Usually I just post weird blots to PubPeer. 👇
Puri Fortes retweeted
China approves the world’s first CAR-T therapy for a solid tumor.
Hours later, the FDA responds with full approval of afami-cel and expansion into pediatric synovial sarcoma.
A remarkable day for cellular therapy.
🇨🇳 Satri-cel (CLDN18.2 CAR-T)
CT041-ST-01, refractory gastric/GEJ cancer
• PFS: 3.25 vs 1.77 months (HR 0.37)
• OS: 7.9 vs 5.5 months (HR 0.69)
• 18-month OS: 20.1% vs 8.6%
• First CAR-T ever approved for a solid tumor
🇺🇸 Afami-cel (MAGE-A4 TCR-T)
SPEARHEAD-1, advanced synovial sarcoma
• ORR: 43%
• CR: 4.5%
• Median DoR: 6.0 months
• Median OS: 15.4 months
• First FDA-approved engineered cellular therapy for a solid tumor
For decades, solid tumors were where cellular therapies went to fail.
Now, on the same day, regulators in China and the United States have approved two different engineered T-cell platforms for two different solid tumors.
A brave new world for solid tumor oncology.
Any cancer center not providing cellular therapies is going to be left in the dust.
@OncoAlert @TheGutOncLab @Onco_Nexus
Puri Fortes retweeted
Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)
cell.com/cell/fulltext/S0092…
Puri Fortes retweeted
What a nice place for the #Ribored2026!
Puri Fortes retweeted
#AptOx26 starting tomorrow - 23rd March - at St Edmund Hall, #Oxford. Vew agenda here:
libpubmedia.co.uk/aptamers-2…
Puri Fortes retweeted
📢 Los fondos son limitados. Ayúdanos a que #científicas en países de desarrollo tengan los recursos que merecen. ¡Cualquier aporte hasta 50€ se multiplica!!
👉¡Dona aquí!
globalgiving.org/projects/em…
Puri Fortes retweeted
New preprint from the group!
Here we use Nanopore dRNA and Ribo-Seq data from multiple yeast species to discover tens of highly conserved microproteins encoded by uORFs in polycistronic transcripts/alternative isoforms. @the_prbb
biorxiv.org/content/10.64898…
Puri Fortes retweeted
"Zorevunersen es el primer tratamiento diseñado para actuar específicamente sobre la causa de #Dravet". Nuestro científico Rubén Hernández comenta en
@elmundosalud los resultados de un estudio internacional publicado en @NEJM
📰 Un reportaje de @cglucio
elmundo.es/ciencia-y-salud/s…
Nature research paper: GlycoRNA complexed with heparan sulfate regulates VEGF-A signalling
go.nature.com/4qfSq3C
Puri Fortes retweeted
Online Now: Why m⁶A? An RNA surveillance model dlvr.it/TQbZpD
Puri Fortes retweeted
More than 2700 3′UTRs are highly conserved.
These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance.
Highly conserved 3′UTRs help the folding of proteins with long IDRs.
biorxiv.org/content/10.1101/…
Puri Fortes retweeted
Prkra dimer senses double-stranded RNAs to dictate global translation efficiency dlvr.it/TKnKD5
Puri Fortes retweeted
After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology. Lately, I’ve focused on unravelling the reasons why diets high in ultra-processed food are linked to epidemic proportions of chronic diseases such as diabetes and obesity. Our research leads the world on this topic.
Given recent bipartisan goals to prevent diet-related chronic diseases, and new agency leadership professing to prioritize scientific investigation of ultra-processed foods, I had hoped to expand our research program with ambitious plans to more rapidly and efficiently determine how our food is likely making Americans chronically sick.
Unfortunately, recent events have made me question whether NIH continues to be a place where I can freely conduct unbiased science. Specifically, I experienced censorship in the reporting of our research because of agency concerns that it did not appear to fully support preconceived narratives of my agency’s leadership about ultra-processed food addiction.
I was hoping this was an aberration. So, weeks ago I wrote to my agency’s leadership expressing my concerns and requested time to discuss these issues, but I never received a response. Without any reassurance there wouldn’t be continued censorship or meddling in our research, I felt compelled to accept early retirement to preserve health insurance for my family. (Resigning later in protest of any future meddling or censorship would result in losing that benefit.) Due to very tight deadlines to make this decision, I don’t yet have plans for my future career.
The NIH has been a wonderful place because it allows scientists to take risks, form unique collaborations, and do studies difficult to conduct elsewhere. I’m proud of what we’ve accomplished and I’m fortunate to have had such wonderful colleagues and scientific collaborators. I hope to someday return to government service and lead a research program that will continue to provide gold-standard science to make Americans healthy.
Puri Fortes retweeted
Don't think I've ever met scientists as terrified/depressed as I've seen in the US this week (and I live in a war zone).
Puri Fortes retweeted
If you work in the area of the TGF-beta pathway , consider to send your publication to this special issue , where Prof. Gianluigi Giannelli and I are guest editors.
TGF-β Signaling in Immunity, Inflammation, Fibrosis and Cancer mdpi.com/si/221331 #mdpiijms @IJMS_MDPI
Puri Fortes retweeted
Imaging single endogenous RNA in live cells comes true!
Single-molecule live-cell RNA imaging with CRISPR–Csm go.nature.com/3EJPKsM
Puri Fortes retweeted
🗓️¡No te lo pierdas! El 11 de febrero #mujeres referentes en #ciencia expondrán las fases de la investigación desde que comienza en un laboratorio hasta que llega a al paciente, en un evento en el #DíadelaMujerylaNiñaenlaCiencia ➡️Toda la información en museodeciencias.unav.edu
Puri Fortes retweeted
Our updated preprint on the mechanism behind the 1st & only human disease linked to tissue-specific ribosome: fatal heart failure caused by RPL3L mutations. Very proud of this work led by the talented and fearless Michael Murphy @MMurphyCUNY—check out his thread for more details!
Excited to share our new preprint from the @wu_xuebing lab: biorxiv.org/content/10.1101/…
In it, we identify a gain-of-toxicity mechanism in RPL3L-linked neonatal dilated cardiomyopathy (DCM), challenging the idea that recessive diseases are primarily caused by loss-of-function.
Puri Fortes retweeted
🔬Nos reunimos con el equipo de la Dra. María Reig @ma5RN del @hospitalclinic-@idibaps para conocer los últimos avances del proyecto RETO. Avances en el Tratamiento del Cáncer de Hígado: Modificar el Microbioma como Nueva Estrategia para Potenciar la Inmunoterapia, dotado con 1,2 millones de euros a través de la ayuda "Proyectos Coordinados AECC 2023".
El grupo estudiará la relación entre la microbiota fecal, el tumor y su microambiente inmune en pacientes con cáncer hepático, con el objetivo de aumentar el número de pacientes que se beneficien de la inmunoterapia. #InvestigandoEnCáncer




























