@ForsellLab

Research lab @UmeaUniversity, studying B cell and antibody responses to microbial infection.

 Umeå, Sverige
Joined May 2019
  • Tweets58
  • Following64
  • Followers103
4Media
1) I feel this paper by Mattias Forsell's group is often overlooked but shows something very important: Binding antibody to SARS-CoV-2 spike - in the absence of strong neutralizing antibodies to a new variant - predict protection from mortality. thelancet.com/journals/lanep….

Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during...

In the absence of neutralizing antibodies that protect from infection, quantification of S-binding IgG post vaccination may be useful to identify the most vulnerable for fatal COVID-19 among the...

thelancet.com
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The lab is recruiting! We're at Karolinska, in Stockholm. We're looking for: - a postdoc with a computational/statistical background, with an interest in evolution and/or deep learning - a few `wetlab' roles, including a postdoc ("antibody stuff"), and lab tech/admin folks. 1/n
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Having a PhD? Interested in epidemiological research on long-term consequences of infectious diseases? Then we have the position for you. Please share! @medfak_LU lupop.lu.se/article/postdoct…
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Happy to share our latest publication: Anti-spike mucosal IgA protection against SARS-Cov-2 omicron infection. Fantastic collaboration with Charlotte Thålin @SmedSorensenLab @KimBlom10 and many more! nejm.org/doi/full/10.1056/NE…

Anti-Spike Mucosal IgA Protection against SARS-CoV-2 Omicron Infection | NEJM

In this study, SARS-CoV-2 infection before vaccination was found to elicit mucosal IgA, which protects against infection. Vaccines inducing mucosal immunity may be important for preventing infection.

nejm.org
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86% efficacy for the @pfizer RSV prefusion F vaccine in the elderly is extremely good news! Looks like there will be multiple RSV vaccines available soon for this target population. Still looking forward to seeing the data later this year from their maternal vaccine trial.
Jamie Smyth@JamieSmythF25 Aug 2022
Pfizer races to beat rivals GSK, J&J, Moderna for slice of $10bn respiratory jab market: will apply for approval of RSV vaccine after reporting its jab is 86% effective at preventing severe disease on.ft.com/3PO5quX
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Received an email from Rino Rappuoli this morning informing me, @BarneyGrahamMD and Peter Kwong of the positive phase III data for the RSV prefusion F vaccine results in older adults. It's been almost 10 years since we designed the first prefusion RSV F antigen, DS-Cav1. Amazing!
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Happy to share latest paper at @scienceTM from our Prometheus consortium on broadly neutralizing antibodies against emerging hantaviruses from human convalescent donors. We're especially excited about one particular antibody we've identified. bit.ly/3JkMly7 1/10

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad...

Human neutralizing antibodies recognizing the viral glycoprotein complex are broadly protective against orthohantaviruses.

science.org
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Happy to see our latest #Covidvaccination study in @regionskane published in @Eurosurveillanc Main message - booster dose necessary to maintain sufficient protection against severe disease. @KahnFredrik Supported by @lunduniversity @vinnovase @Vetenskapsradet
Eurosurveillance@Eurosurveillanc6 May 2022
Replying to @Eurosurveillanc
Rapid communication: #COVID19 #vaccineeffectiveness against severe disease from #SARSCoV2 Omicron BA.1 and BA.2 subvariants – surveillance results from southern 🇸🇪, December 2021 to March 2022 👇🏾 bit.ly/EUS2718VE #Omicron #ba2variant #Covidvaccination @LU_Jonas_Bjork
The authors compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Picture: Getty images

ALT The authors compared vaccine effectiveness against severe COVID-19 between December 2021 and March 2022 when Omicron BA.1 and BA.2 were the dominating SARS-CoV-2 variants in Scania county, Sweden. Picture: Getty images

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A synopsis of some of our recent hantavirus work hsc.unm.edu/news/2022/04/res…
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Molecular analysis of the B cell response following Omicron breakthrough infection, in collaboration with @ForsellLab ! biorxiv.org/content/10.1101/…

Recall of pre-existing cross-reactive B cell memory following Omicron breakthrough infection

Understanding immune responses following SARS-CoV-2 breakthrough infection will facilitate the development of next-generation vaccines. Here, we profiled spike (S)-specific B cell responses following...

biorxiv.org
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Enjoyed listening to @profvrr and colleagues discussing our recent work in @ScienceTM on broadly protective human antibodies vs hantaviruses in TWiV 881 (microbe.tv/twiv/twiv-881/). Informative and entertaining as always 😁 Link to 🧵 on our paper: xitter.cf/ChandranLab/status/150…

TWiV 881: 50 ways to zap your virus

TWiV describes the identification of a monoclonal antibody that provides broad protection against a variety of hantaviruses, and development of an oral remdesivir-like antiviral that ameliorates...

microbe.tv
Kartik Chandran@ChandranLab16 Mar 2022
Happy to share latest paper at @scienceTM from our Prometheus consortium on broadly neutralizing antibodies against emerging hantaviruses from human convalescent donors. We're especially excited about one particular antibody we've identified. bit.ly/3JkMly7 1/10

Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad...

Human neutralizing antibodies recognizing the viral glycoprotein complex are broadly protective against orthohantaviruses.

science.org
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🙏🏾 Prometheus: 1st authors @MittlerEva (pic), @AnnaWec1, J Tynell. +@LauraMWalker2, M Forsell & C Ahlm @UmeaUniversity, @StrandinTomas, A Herbert & J Dye @usamrdc, @virusfusion007, @LarryZeitlin, @StevenBradfute, @cheelopow, @jangralab, @ZABornholdt, ++others,@NIAIDFunding /fin
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Kartik Chandran, Ph.D., and Denise Haslwanter, Ph.D., describe their study that finds the human antibody response induced by the widely used yellow fever vaccine has reduced activity against the recent Brazilian strain of the virus. Read more at wb.md/3fgOwoK #research
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Happy to share that our paper on the ancestral SARS-CoV-2-specific T cell response against Omicron is now accepted and online in Nature Medicine. Amazing team-effort from all people involved in this work! nature.com/articles/d41591-0…

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Nature Medicine - Peripheral ancestral SARS-CoV-2 spike-specific CD4+ and CD8+ T cells induced by BNT162b2 vaccination cross-react to the Omicron variant at higher levels than those induced by...

nature.com
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Our new manuscript with @virusfusion007 on structures of CCHFV Gc alone and in complex with highly potent neutralizing antibodies is now live: science.org/doi/10.1126/scie…. Excellent work from the lead authors @AkaashMishra88 and Jan Hellert, as well as our Prometheus colleagues!

Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human...

Elucidating antibody neutralization mechanisms of a pathogenic virus provides a foundation for developing countermeasures.

science.org
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Happy to share our study on airway antibody responses to SARS-CoV-2 across COVID-19 disease severity and after vaccination. Great collaboration with Loré lab @farnert_lab @ForsellLab @doc_brown79 and many others!@karolinskainst @KarolinskaUnsju
JCI insight
@JCI_insight19 Oct 2021
Just Published: Airway antibodies emerge according to #COVID_19 severity and wane rapidly but reappear after SARS-CoV-2 vaccination: buff.ly/3n5CIJL @SmedSorensenLab @karolinskainst #Immunology
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Forsell Lab retweeted
CavaLab@CavaLab_MIMS4 Oct 2021
This Friday seminar we have Alvaro San Millán taking about antimicrobial resistance. Join us! @mims_umea, @Ucmr_sweden, @UmeaUniversity @WCMM_UmU
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Excited to be named the 2021 Texas Inventor of the Year! Many thanks to everyone in the lab and all our terrific collaborators!
Jay Hartzell
@JCHartzell22 Jun 2021
Well-deserved recognition for @UTAustin Professor Jason McLellan whose biomedical research helped develop vaccines and treatments for #COVID-19 cns.utexas.edu/news/jason-mc…

Jason McLellan Named Texas Inventor of the Year

Jason McLellan Named Texas Inventor of the Year

molecularbiosci.utexas.edu
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At this point, you are either vaccinated or you are going to catch Delta. And whether you are young adult or old, when you catch Delta unvaccinated, you will have the highest chance of being hospitalized compared to almost any disease you have caught in your life.
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Excited to share latest work in @CellCellPress from our Prometheus consortium (pic). Our charge is to discover and develop human antibody-based therapeutics against emerging viral threats. See thread below. Author version of paper: authors.elsevier.com/a/1dAD5…
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