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Read about the impact of integration in #microfluidics-based #organ-on-a-chip technologies on #drug design and biochemical #sensing in the review paper published in Biosensors. doi.org/10.3390/bios14090425

To address the high failure rates in clinical drug trials for Alzheimer’s and Parkinson’s diseases, organ-on-a-chip platforms offer a promising tool, due to their ability to mimic human-specific tissue niches in vitro. Read the review by Kamm et al. onlinelibrary.wiley.com/doi/…

Recent advances in #Organ-on-a-Chip models highlight integration of precision engineering and cutting edge technologies in #microfabrication for the development of preclinical therapeutic models. See sciencedirect.com/science/ar…

A #microfluidic device fabricated by #FlowJEM was used to perform a single-cell #transcriptomic study of brain and blood cells after #ischemic stroke. Phenotypic diversification occurred within the brain in the early and recovery phases of ischemic stroke. nature.com/articles/s41590-0…

Interactions between #endothelial cells and the #immune environment in the #heart after #myocardial #infarction are poorly understood. FlowJEM #microfluidic devices helped to identify #immune regulatory gene signature in #heart failure tissues. life-science-alliance.org/co…

FlowJEM #microfluidic devices were used to generate a genetic #medulloblastoma #model. Inactivating AMPK depleted #tumor #stem cells and slowed down tumor progression. iScience 2023:108443. doi: 10.1016/j.isci.2023.108443.

#SERS imaging may provide enhanced #Raman signals of cells or biomolecules and be adapted to portable systems used in POC. Read a review on combining #MFs platforms with SERS for POC analysis of #proteins, #biomarkers and #pathogens. sciencedirect.com/science/ar…

Human #organ-on-a-chip platforms for #disease modeling, #drug development and screening, and #personalized therapies are gaining momentum! Read review at europepmc.org/article/med/37…

Timely intervention of preventative and therapeutic measures abated a 2022 monkeypox global outbreak. The potentials of human #skin-on-a-chip as a valuable model for #mpox disease evaluation are discussed by Abaci et al. at doi.org/10.1016/j.tips.2023.…

As collagen #fiber alignment is a sign of pathological #scarring and #fibrosis, an approach to collagen matrices with controlled fibril alignment was developed using #3D printed inclined surfaces to study fibroblast behavior to reveal scar progression. onlinelibrary.wiley.com/doi/…

The review on complex in vitro cell culture stresses the importance of fluid flow, as illustrated by #organ on a chip #microfluidic liver models, and stresses economic benefits of more accurate models for drug toxicity (doi: 10.3389/ftox.2023.1170193)

Patterns on a #master Si wafer fabricated by FlowJEM were used to make #polydimethylsiloxane stamps for #microcontact printing to study truncation mutations in cardiac myosin binding protein C. Read J Gen Physiol (2023) 155 (4): e202213204. doi.org/10.1085/jgp.20221320…

FlowJEM #microfluidic devices have been used to show that inflammation in osteoarthritis patients affects differently bone and muscle endothelial cells, suggesting increased angiogenesis in subchondral bone. Read doi.org/10.1038/s42003-023-0… in Communications Biology.

Efficiency and cost of #pharmaceutical analysis can be improved by using #organonachip and #organoidsonchips platforms. Read about #microfluidic platforms for drug screening at sciencedirect.com/science/ar…

A Drop-Seq #MF device fabricated by FlowJEM enabled #single-cell #RNA sequencing that allowed for the transcriptomic profiling of a sample tissue with single-cell resolution. link.springer.com/protocol/1…

Read Expert Opinion about latest models for the discovery and development of rheumatoid arthritis drugs using #2D/3D cell culture models, liquid bioreactors, and complex #joint-on-a-chip devices. pubmed.ncbi.nlm.nih.gov/3618…

The developing lung #metastatic niche in a model of #metastatic, triple-negative #breast cancer was dissected using #single-cell RNA-sequencing using #microfluidic devices fabricated by FlowJEM. Read link.springer.com/article/10…

#Microfabrication of #microfluidic devices by FlowJEM enabled #extraction of high-quality RNA rapidly and simply from a small quantity of blood, thus, making this process more accessible. aip.scitation.org/doi/10.106…

#Microfluidic blood-brain barrier (BBB) models, evolved from #tissue engineering and #microfabrication technology, facilitate biomedical research and drug discovery by recapitulating the complexity of the human BBB in vitro. sciencedirect.com/science/ar…