Assistant Professor @ZuckermanBrain @ColumbiaBiochem. Lab uses cryo-EM & biophysics to study the cellular, molecular, and structural basis of neurodegeneration.

New York, NY
Joined January 2013
New "Mindscapes" exhibit @ZuckermanBrain featuring #cryoEM structures of #TMEM106B #amyloid fibrils (doi.org/10.1016/j.cell.2022.…) & the ligand-bound human sweet receptor (doi.org/10.1016/j.cell.2025.…) from the Fitzpatrick (fitzpatrick-lab.org) & Zuker (zukerlab.com) labs.
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Forward-looking preview by @WUBin10069342 to our latest paper @Structure_CP by @AndrewNChang highlighting the power of #AI in #cryoEM of patient-derived samples: tinyurl.com/tu2fyvme Paper: tinyurl.com/3cycffzm Thanks to @pixelbaumarkt @Intein for #crYOLO, & @cryosparc
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New preprint from @DuXDaniel @FitzpatrickLab shows #femtosecond light pulses can lens electron beams, promising higher contrast in #cryoET and better aberration correction in #cryoEM biorxiv.org/content/10.1101/… Experiments made possible by support from @cziscience #ImagingTheFuture
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Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress! sciencedirect.com/science/ar…
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It was a pleasure to host Professor Wolfgang Baumeister and share the latest results on developing an #ultrafast #laser #phaseplate for #cryoEM and #cryoET from @FitzpatrickLab @ColumbiaBiochem @ZuckermanBrain
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For all #cryoEM practitioners in #NYC, @FitzpatrickLab is excited to host Prof. Wolfgang Baumeister next Thursday with attendance open to all and no registration necessary. Hope to see you there!
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Looking out for grad student @william_mallen complete his first marathon!
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Savoring a farewell butcher's feast for our visiting scientist, Julia Pichler from @FU_Berlin, at @cotesteakhouse with @andrewnchang, @carolynlinlee, @william_mallen and @FitzpatrickLab. It has been wonderful hosting you, Julia! We hope to see you again next summer.
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Yet another weekend #cryoEM data collection ruined by the K3 "stripe of death"
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