@FesenkoIgor

Peptidomics; Proteomics; Microproteins; tweeting as an individual

 Cambridge, MA
igorfesenko.github.io
Joined November 2017
  • Tweets1.1K
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132Media
Excited to share our publication on bacterial microproteome cell.com/molecular-cell/full… #microproteins #smORFs @storzlab

The hidden bacterial microproteome

This study uncovers thousands of microprotein families encoded by intergenic small open reading frames (smORFs) in bacterial genomes and provides a publicly available resource featuring structural...

cell.com
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(1/2) How did RNA and peptides organize before specific protein sequences existed? Our new study shows that heterogeneous peptide populations can spontaneously form liquid-like RNA-rich condensates with a model of the ancient ribosome.
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I started reviewing the paper and found this in the Introduction 😄
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Happy to announce that our paper on orphan genes in bacteria dropped in PNAS yesterday! This is a problem I've been thinking about since the start of my PhD. Grateful for this journey, as well as All The Friends I Made Along the Way. Also, Eid Mubarak to those who celebrate!
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New online! Emergence and evolution of protein-coding de novo genes dlvr.it/TQcswP
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Igor Fesenko retweeted
Anne Lopes@anne__lopesJan 12
Fresh news on de novo genes! Happy to present our latest work published in Nature communications: nature.com/articles/s41467-0… Keywords not in specific order: intergenic ORFs, de novo genes, GC content, foldability, genetic code, ancestral sequence reconstruction and more :)
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Our lab has finally received its New Year’s gift
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I am happy to present our new paper on the de novo birth of microproteins in bacterial intergenic regions, conducted in collaboration with #storzlab. academic.oup.com/nar/article…

De novo origin of numerous microproteins in enterobacteria

Abstract. Bacterial genomes encompass numerous small open reading frames (smORFs), some of which encode functional microproteins or perform noncoding regul

academic.oup.com
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I am happy to present our new paper on the de novo birth of microproteins in bacterial intergenic regions, conducted in collaboration with #storzlab. academic.oup.com/nar/article…

De novo origin of numerous microproteins in enterobacteria

Abstract. Bacterial genomes encompass numerous small open reading frames (smORFs), some of which encode functional microproteins or perform noncoding regul

academic.oup.com
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We identified clear signatures of de novo origin for 4,838 microOGs. These smORFs often overlap with regulatory elements in intergenic regions, suggesting that translation-coupled regulatory mechanisms of gene expression may contribute to de novo microprotein emergence
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Our analysis indicates that bacterial pangenomes are largely closed, suggesting that the capacity of intergenic regions to generate de novo genes is limited.
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Latest from the lab: we’ve found that arbitrium phages can cross-communicate across species. Their molecular “language” isn’t as private as we thought. The original idea came from @AlbertoMarina14. As always, he was right. biorxiv.org/content/10.1101/…

Phages communicate across species to shape microbial ecosystems

Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX...

biorxiv.org
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Igor Fesenko retweeted
Bruno Ngou@BrunoNgou4 Sep 2025
Very happy to share our latest work “Systematic discovery and engineering of synthetic immune receptors in plants” out in @ScienceMagazine! science.org/doi/10.1126/scie…

Systematic discovery and engineering of synthetic immune receptors in plants

Plants deploy a diverse array of pattern recognition receptors (PRRs), which perceive microbe-associated molecular patterns to activate immune responses. Leucine-rich repeat receptor-like kinase...

science.org
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New Letter: "Large-scale pairing identifies a soybean phytocytokine-receptor module conferring disease resistance" rdcu.be/eBmrZ Scalable pipeline for systematic peptide–receptor discovery. In soybean, identification of a PEP914/890-P98R module in disease resistance.
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Igor Fesenko retweeted
Cell@CellCellPress21 Aug 2025
Now online! A receptor antagonist counterbalances multiple systemin phytocytokines in tomato dlvr.it/TMcdxq

A receptor antagonist counterbalances multiple systemin phytocytokines in tomato

Tomato antiSYS is a natural receptor antagonist that counterbalances agonistic systemin phytocytokines. Its deficiency triggers autoinflammatory-like symptoms affecting growth and development of...

cell.com
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15th symposium on proteomics in the life science has started in Boston #ASBMB
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🧬 How have tiny immune-signaling peptides evolved across the plant kingdom? Comparative analysis of small secreted peptide signaling during defense response: insights from vascular and non-vascular plants bit.ly/4eAUnmZ
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Dipeptid from microbiota binds plant strigolactone receptor cell.com/cell/fulltext/S0092…

Root microbiota regulates tiller number in rice

The root-associated bacterium Exiguobacterium R2567 regulates tiller number by producing cyclo(Leu-Pro), which activates the rice strigolactone signaling pathway.

cell.com
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Shining a Light on the World of Tiny Proteins nytimes.com/2025/06/12/scien… via @NYTimes

Shining a Light on the World of Tiny Proteins (Published 2025)

From viruses to humans, life makes microproteins that have evaded discovery until now.

nytimes.com
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