We smash & trash; we #PROTAC and attac 💣 We discover new drug targets & hijack the #ubiquitin system to remove them💊 Tweets by PI @BekkyFeltham @WEHI_research
Melbourne, Victoria
Joined November 2019
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Feltham Lab retweeted
Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia.
Late abstracts are still being accepted—worth checking out!!! 🦘🦘🦘
Feltham Lab retweeted
Had an exciting morning of #TargetedProteinDegradation at the launch of Ternarx! @ternarx49306 Fantastic to have strong support from @Mark_Butler_MP and the incredible team @WEHI_research.
🔗 Explore our journey and vision: [WEHI Announcement](wehi.edu.au/news/wehi-spinou…)
Ternarx is the first biotech company of its kind in Aus. focused on developing targeted #proteindegrader medicines for hard to treat #cancers. A great partnership with WEHI, @MonashUni & @KidsCancerInst, backed by $15m in #MRFF @healthgovau funding.
wehi.edu.au/news/wehi-spinou…
🧵2/2
Feltham Lab retweeted
Abstract submissions for 2024 @LorneProteins, incl. the Satellite Meeting on "Ubiquitin signalling: Molecular mechanisms, biology and targeted protein degradation" are closing soon. If you work on #ubiquitin, ubiquitin-like modifiers, #PROTACs or #TPD, we want to hear from you!
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Feltham Lab retweeted
The Vervoort and @FelthamLab @BekkyFeltham are looking for an enthusiastic Research Assistant who wants to join our labs for a year to kickstart an exciting new project on degron therapeutics in cancer. Check it out and please share: wehi.wd3.myworkdayjobs.com/e…
Feltham Lab retweeted
WEHI researcher Dr @BekkyFeltham was always intrigued by biochemistry. These days Dr Feltham heads up a #UbiquitinSignalling laboratory searching for new therapies to treat #InflammatoryDiseases
Discover more in the new edition of Illuminate wehi.edu.au/news/illuminate-…
Feltham Lab retweeted
#cIAP1-based %degraders induce #degradation via branched #ubiquitin architectures | Nature Chemical Biology nature.com/articles/s41589-0…
Feltham Lab retweeted
An expanded Lexicon for the Ubiquitin code by @idikic @IBC2_GU & Brenda Schulman @MPI_Biochem 😳
New types of #Ubiquitin modifications on serine, threonine, lipids, sugars, also on ADPR..opportunities for innovative #therapeutics
nature.com/articles/s41580-0…
rdcu.be/cYfBR
Feltham Lab retweeted
Wow!!! Congratulations @Nurix_Tx for having achieved a complete (!) response in a patient with aggressive Non-Hodgkin's Lymphoma using their using a small molecule degrader. So wonderful to see these clinical data emerge with targeted protein degradation!
ir.nurixtx.com/news-releases…
Feltham Lab retweeted
A big mystery solved? Endogenous function of the CRBN Ligase revealed by Christina Woo et al @Nature!! Spoiler…it’s all about protein quality control. CRBN recognizes damaged proteins with cyclic di-peptides that mimic IMiDs! So cool👏👏 nature.com/articles/s41586-0…
Feltham Lab retweeted
Nature research paper: Antibody targeting of E3 ubiquitin ligases for receptor degradation nature.com/articles/s41586-0…
Feltham Lab retweeted
How cool is that? New paper @Nature, E3 #ubiquitin ligases keep on giving
#Proteindegraders #PROTACs
nature.com/articles/s41586-0…
Feltham Lab retweeted
Target protein localization and its impact on PROTAC-mediated degradation: Differentially localized proteins showed varying levels of degradation with PROTACs cell.com/cell-chemical-biolo…
Feltham Lab retweeted
Day 2 of #DegradersDownUnder
@mediocre_jake introducing our first speakers including @kdonovan1008 & @MilkaKostic from @DanaFarber.
Feltham Lab retweeted
After PROTACs, here come DUBTACs:
nature.com/articles/s41589-0…
Feltham Lab retweeted
📢 all targeted protein degradation #TPD and #PROTAC fans in 🇦🇺and 🌎. Join us for Degraders Down Under at @WEHI_research or virtual on 12/13 July.
Free registration (in-person and virtual) here:
eventbrite.com.au/e/degrader…
The first Australian #TPD meeting will be held in July! In person @WEHI_research and online. Registration open now #DegradersDownUnder
Feltham Lab retweeted
The @FelthamLab hopes to dramatically reduce the #biomedical industry's high drug failure rate by enhancing protein degrader technology to show whether potential treatments are worth progressing into human trials. #gameChanging #CancerResearch
Read more wehi.edu.au/news/research-bo…
Feltham Lab retweeted
The @FelthamLab describes a new tag-based method for targeted protein degradation and benchmark existing tag-targeted degradation platforms using a novel reporter system. @WEHI_research
go.nature.com/3wou2Uy
Feltham Lab retweeted
We are looking for postdocs that can start anytime in the next 12 months and are keen to tackle the big questions using cutting-edge technologies. Wet- and dry-lab scientists with expertise in genomics, CRISPR-Cas9 genome-engineering, screening & bioinformatics please contact us