@FapySenior
 West Virginia, USA
Joined August 2020
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senior fapy retweeted
Elva Hu@elvahupinOct 3
Photofluidization of Azobenzene-Based Smart Materials: Fundamental Mechanisms, Structural Classifications, and Surface Patterning Applications
SmartMat@SmartMat2Oct 3
Photofluidization of Azobenzene-Based Smart Materials: Fundamental Mechanisms, Structural Classifications, and Surface Patterning Applications doi.org/10.1002/smm2.70111
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Photofluidization of Azobenzene-Based Smart Materials: Fundamental Mechanisms, Structural Classifications, and Surface Patterning Applications
SmartMat@SmartMat2Oct 3
Photofluidization of Azobenzene-Based Smart Materials: Fundamental Mechanisms, Structural Classifications, and Surface Patterning Applications doi.org/10.1002/smm2.70111
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Donor engineering of D–A–D BOIMPY derivatives for efficient NIR-II photothermal therapy @Boron_Chemistry sciencedirect.com/science/ar…
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Boron Monofluoride Complexes Bearing π‐Expanded Coumarin Subunits: Facile Synthesis, Crystal Structure, and Solid‐State Enhanced Emission ( @ChemEurJ ): doi.org/10.1002/chem.71756 .
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Excited to share our latest preprint on @ChemRxiv ! 🌪️ We demonstrate how terminal engineering of helical nanographenes dictates both columnar packing and NIR chiroptical responses. A rational approach to tailoring functional helicenes. chemrxiv.org/doi/full/10.264…
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organic-chemistry.org/abstra… A variety of primary amines were converted to their corresponding N-(benzoyloxy)amines under biphasic conditions in excellent yields.
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Nickel-Catalyzed Hydroamination of Olefins Utilizing Isoxazole as an NH3 Surrogate for the Synthesis of Aliphatic Primary Amines
Sihao Shen@yxxwqhts_coysSep 8
Concise Report Nickel-Catalyzed Hydroamination of Olefins Utilizing Isoxazole as an NH3 Surrogate for the Synthesis of Aliphatic Primary Amines doi.org/10.1002/cjoc.70700 CJC (IF 5.7) editorial board is seeking global chemists! #CJC #Chemistry #Organic #ChemTwitter #OrgChem
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Olympic-patterned pentaboron emitter featuring highly distorted geometry enables efficient solution-processed ultrapure green OLEDs ( @ChemRxiv ): chemrxiv.org/doi/full/10.264… .
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Direct Decarboxylative Borylation ( @J_A_C_S ): pubs.acs.org/jacsat/article/… ( @FranciscoJH84 , @FjhGroup ).
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senior fapy retweeted
Aggregate
@AggregateOASep 20
Helically Flexible Boron-Dipyrromethenes for Solution-Processed Isotropic Films With Preserved Chiral Exciton Coupling doi.org/10.1002/agt2.70411
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Enantioenriched Alkylboron Synthesis Via a Chiral Diborylalkane Platform ( @J_A_C_S ): pubs.acs.org/jacsat/article/… .
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Regulating noncovalent interactions to construct one-dimensional lead-free molecular ferroelectrics for efficient passive X-ray detection doi.org/10.1016/j.cclet.2026…
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Bimodal multiphoton catalysis via structural regeneration dlvr.it/TV13Tx
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senior fapy retweeted
Zhichang Liu@zhichang_liuAug 13
Calix[n]phenoselenazines: Macrocyclization-regulated transition from TADF to room-temperature phosphorescence
Chinese Chemical Letters@ChinChemLettAug 13
Calix[n]phenoselenazines: Macrocyclization-regulated transition from TADF to room-temperature phosphorescence @TADF_papers doi.org/10.1016/j.cclet.2026…
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Explore our diverse collection of mono-, di-, and tri- fluoro-𝘵𝘦𝘳𝘵-butyl compounds to engineer lipophilicity, permeability, and p𝘒ₐ features of your bioactive molecules: bit.ly/4cvs755 Try our fluoroalkyl motifs in your research!
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Lewis Acidity and Anion-Complexation Ability of Oxo- and Phenylimino-Bridged Planar Triphenylboranes as Lithium-Ion-Conducting Solid-State Electrolytes ( @ChemEurJ ): chemistry-europe.onlinelibra… ( @KitamotoYuichi ).
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Our work on bis-radical Fe(0)Fe(II)Fe(0) complexes in collaboration with @TheNeidigLab is finally online in Inorg. Chem. ! @ERC_Research @ACSPublications pubs.acs.org/inocaj/article-…
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Synthesis and Selective Carboboration Reactivity of a Flexible P-Stabilized Bromoborenium ( @InorgChem ): doi.org/10.1021/acs.inorgche… ( @dbouriss )
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これは逆転の発想的な新しい創薬概念でおもしろい！🤩 通常はKRAS変異体の機能を「阻害」する戦略を取るが、変異で失われたGTPase触媒機能を低分子化合物で化学的に「復活」させるという逆の戦略！🎯 そもそも正常なRASは、 1️⃣RAS-GTP（活性型） 2️⃣GTP加水分解 3️⃣RAS-GDP（不活性型） というサイクルによってシグナルを制御しているが、 Q61変異体ではGTP加水分解に不可欠なアミノ酸を変異で失うことでRASが活性型のGTP結合状態（2️⃣）に偏り、下流シグナルを持続的に活性化！ そのため、HRAS/NRAS-Q61変異は頭頸部癌とメラノーマのそれぞれで約60%と85%という高い割合で見られます🧬 それにもかかわらず、Q61HやQ61L、Q61K、Q61RなどのQ61変異に対する変異選択的阻害薬は依然として乏しいのは問題🙅‍♂️ そこで、すべてのQ61変異体のGTPase機能を復活させる目的でKRASのswitch-IIポケットに結合するMRTX1133にイミダゾールなどのブレンステッド塩基を導入した化合物を設計しています（下図参照）👇 実際にこの化合物によって、GTPase機能が失活したKRAS-Q61変異体が濃度依存的にGTP加水分解できるように復活しています！🎊 つまり、KRASとしては不活性型ということですね さらにこの化合物は、KRAS-Q61変異を持つ下記のヒトがん細胞株でもGTPase活性を復活させ、下流のERKリン酸化を低下させることにも成功しています👏 🔹大腸癌：SW948（KRAS-Q61L） 🔹非小細胞肺癌：Calu-6（KRAS-Q61K） 🔹非小細胞肺癌：NCI-H460（KRAS-Q61H） いやー、1剤で複数のKRAS-Q61変異体に効かせられるのは良きですね！🥰 一方で、この化合物は細胞で薬効を示すのに30 µMという高濃度が必要なのは改善ポイントですな〜 あとは今回ベースにした化合物はHRAS/NRAS-Q61に結合できないので、すべてのRASに高親和性に結合できる化合物をベースすれば最高ですね！🙌
Nature Chemical Biology@nchembioAug 12
Bronsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants nature.com/articles/s41589-0…

Brønsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants

Nature Chemical Biology - Through chemical complementation, Brønsted-basic small molecules rescue the loss of the catalytic glutamine side chain in KRAS-Q61X mutants, accelerating GTP...

nature.com
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Fluorophore-coating liposomes doi.org/10.1016/j.cclet.2026…
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