Scott C Kogan MD

Also important but less discussed substrates of thrombin include Factor 11 (eleven) and TAFI (Thrombin activatable fibrinolysis inhbitor)

Thrombin Substrates: So far I mentioned F5 and F8. Other key substrates include Fibrinogen, Platelets, Factor 13 & Protein C.

Tissue Factor-F7 activates a bit of F9 and F10. F8a-F9a powerfully activates more F10. F5a-F10a powerfully activates thrombin.

Full activation of thrombin depends on thrombin activating two of its substrates: Factor 8 and Factor 5.

When a vessel is damaged, Tissue Factor-Factor 7 (F7) complex activates F10 which activates Prothrombin to Thrombin...just a bit at first

Thrombin (Factor 2) = center of the coagulation universe! How does thrombin get activated? How many substrates of thrombin can you name?

You might need to follow me to see the cell...

I would like to welcome all the new residents to UCSF's Anatomic and Clinical Pathology Program. Do you recognize this cell?

What's wrong with high molecular weight vWF multimers in 2A/2B/2M (simplified)? A=absent, B=bound (to plts), M=messed up (don't bind plts)

vWD Dx point: If vWF Ristocetin cofactor activity: vWF antigen ratio is low, this can reflect type 2A, 2B, or 2M.

Thrombin time= underutilized test. Terrific for picking up presence of thrombin inhibitors: heparin, DTIs, paraneoplastic heparinoid.

A surprising aspect of vWD is that the null alleles associated with type 3 do not cause type 1 when they are heterozygous: 50% VWF is enough

Factor inhibitors can be quantified in Bethesda Units. Patient & Normal plasma are mixed. 1 BU = Amount that inhibits half of Factor present

Welcoming new Trainees at UCSF for another year! Coag tweets to follow!!

Thrombin Sbstrt A4=F11.Thrombin activation of F11 maintains thrombin generation following major injury and in tissues with high fibrinolysis

Back to Thrombin Substrates. A2/A3: Factors 5 & 8 (the critical cofactors of Factors 10 & 9). Primary amplification for thrombin generation

Fondaparinux. In the unlikely event that a level will be checked, 3 hours post dose is suggested (as compared to 4 hours post dose for LMWH)

This anticoagulant medication is a pentasaccharide that will interact with antithrombin and inhibit Factor10a and F9a. Name it.

Thrombin Substrates? A1-part 2: Fibrinogen. Fibrinogen is also substrate for platelet binding through gpIIbIIIa receptor.

Thrombin Substrates? A1: Fibrinogen. Converted to Fibrin. Fibrin monomers polymerize to fibrin clot.