@FKH_Lab

Professor of Pharmaceutical Chemistry at University of Bonn, Germany. Vice speaker of @GRK2873.

 Bonn, Deutschland
pharma.uni-bonn.de/www/pharmchem2/ak-hansen-en?set_language=en
Joined March 2018
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  • Following393
  • Followers593
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Finn K. Hansen retweeted
Guillaume Laconde@Glaconde34Jan 2
Discovery of Histone Deacetylase 8-Specific Proteolysis-Targeting Chimeras with Anticancer Activity against Hematological Malignancies | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…

Discovery of Histone Deacetylase 8‑Specific Proteolysis-Targeting Chimeras with Anticancer Activity...

Abstract. Histone deacetylase 8 (HDAC8) has emerged as promising therapeutic target for several malignancies. In this study, we developed two series of cer

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Happy to share our new review on the crosstalk between #NLRP3 signaling and #HDACs in #inflammasome driven diseases, just published in #JMedChem. Congrats to my postdoc and first author Kathrin, and all collaborators! pubs.acs.org/doi/10.1021/acs…

Crosstalk between NLRP3 Signaling and Histone Deacetylases in Inflammasome-Driven Diseases

Abstract. The NLRP3 inflammasome is a validated therapeutic target in inflammatory, metabolic, and neurodegenerative diseases. Epigenetic regulators, parti

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Happy to share our newest paper. Congrats to first author Irina! Slow-Acting HDACi are still puzzling!!! Congrats also to Tao, Nisha and Linda for their important controbutions to this project. pubs.acs.org/doi/10.1021/acs…

Ortho-Hydroxyanilides: Slow-Acting, Selective Histone Deacetylase 1/2 Inhibitors Suitable for...

Abstract. Histone deacetylases (HDACs) regulate gene expression and are promising targets in oncology. Especially the class I isoforms HDAC1 and HDAC2 are

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Happy to share our publication dealing with the targeted #HDAC degradation via direct DDB1 recruitment. Congrats to first author Shiyang @Vincent_SYZ and everybody involved. Great collaboration with the Geyer lab @Geyer_lab! #BonnTPD pubs.acs.org/doi/10.1021/acs…

Targeted Histone Deacetylase Degradation via Chemical Induced Proximity by Direct Recruitment of...

Abstract. Targeted protein degradation using proteolysis-targeting chimeras (PROTACs) has emerged as a powerful strategy for disease treatment. By recruiti

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Happy to share the latest publication from my lab: we developed a NanoBRET based target engagement assay for HDAC6. Furthermore this system allows to track the HDAC6 degradation by PROTACs in real-time. Congrats to my postdoc Maria and everybody involved.pubs.acs.org/doi/10.1021/acs…

Target Engagement Studies and Kinetic Live-Cell Degradation Assays Enable the Systematic Characte...

Abstract. Histone deacetylase 6 (HDAC6) is an important drug target for the treatment of cancer, inflammation, and neurodegenerative disorders. In recent y

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Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/acs…
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The University of Bonn offers two PhD scholarship financed by the DAAD within the DAAD-GSSP Programme. The PhD students will be associated to the Research Training Group RTG/GRK 2873 @grk2873 Apply now! Please RT. grk2873.uni-bonn.de/en/train…
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Happy to see our dual HDAC6/10 #PROTAC paper out in #JMedChem. I am extremely proud of my PhD student Shiyang @Vincent_SYZ for making this possible. Huge thanks to all collaborators and co-workers for their amazing contributions! pubs.acs.org/doi/10.1021/acs…

Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders

Abstract. Proteolysis-targeting chimeras (PROTACs) are emerging new therapeutic modalities that facilitate the targeted degradation of disease-relevant pro

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Thrilled to see Our FerroTac story is now out at @J_A_C_S - Huge congrats 🙌🏻 🥳 @ales_salerno Lianne and Claudia! @UoDCeTPD
J. Am. Chem. Soc.@J_A_C_S10 Apr 2025
Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes | Journal of the American Chemical Society @alessiociulli @Dundeeuni @UoDCeTPD. @AmphistaThera pubs.acs.org/doi/10.1021/jac…

Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic...

Abstract. Proteolysis Targeting Chimeras (PROTACs) are bifunctional molecules that induce ubiquitination and degradation of a target protein via recruitmen

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#ChemMedChem Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a Selective Histone Deacetylase 6 PROTAC into a Pan-Degrader (Finn K. Hansen and co-workers) #openaccess 🔓 onlinelibrary.wiley.com/doi/…

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a...

This study introduced DCAF11 as an E3 ligase for PROTAC-mediated histone deacetylase (HDAC) degradation. By replacing cereblon with DCAF11 as recruited E3 ligase, a selective HDAC6 degrader (A6) was...

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Happy to share the final version of our DCAF11-recruiting #HDAC #PROTAC paper. Congrats to my co-workers Felix @fellerflix, Heiko, Martina, Irina and Maria! chemistry-europe.onlinelibra…

Replacing a Cereblon Ligand by a DDB1 and CUL4 Associated Factor 11 (DCAF11) Recruiter Converts a...

This study introduced DCAF11 as an E3 ligase for PROTAC-mediated histone deacetylase (HDAC) degradation. By replacing cereblon with DCAF11 as recruited E3 ligase, a selective HDAC6 degrader (A6) was...

chemistry-europe.onlinelibrary.wiley.com
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The next chapter of our HDAC #PROTAC story: CRBN-recruiting PROTACs based on a non-selective ethylhydrazide #HDAC warhead induce selective HDAC6 degradation. Congrats to my PhD students Daniel @danicious & Irina (co-first authors), and Felix @fellerflix. pubs.acs.org/doi/full/10.102…

Development of Ethyl-Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs

Abstract. Histone deacetylases (HDACs) are promising targets for epigenetic drug discovery. Additionally, targeted degradation of HDACs has emerged as a no

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Thrilled to share our #JMedChem paper dealing with DS-103! The ethylhydrazide DS-103 fully reverses cisplatin resistance and binds to HDAC6 in a manner similar to a hydroxamate. Huge congrats to first authors Daniel @danicious & Lukas and the entire team! pubs.acs.org/doi/10.1021/acs…

Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103...

Abstract. In this work, we synthesized a series of peptoid-based histone deacetylase (HDAC) inhibitors with variations in the linker region and zinc-bindin

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Happy to share our latest paper in #JMedChem on improved antagonists targeting the intracellular allosteric binding site of CCR7! Huge thanks and congratulations to the whole team for the incredible teamwork! pubs.acs.org/doi/10.1021/acs…

A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular...

Abstract. Intracellular ligands of G protein-coupled receptors (GPCRs) are gaining significant interest in drug discovery. Here, we report the development

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Excited to share our latest publication on #HDAC inhibitor-based multineurotarget drugs as a potential treatment option for Alzheimer´s disease, now online in ACS Pharmacology & TS! 🎉 Huge congrats to our amazing team and collaborators! pubs.acs.org/doi/full/10.102…

Contilisant-Belinostat Hybrids: Polyfunctionalized Indole Derivatives as Multineurotarget Drugs for...

Abstract. In this work, we designed, synthesized, and evaluated two types of multineurotargeting compounds using a pharmacophore merging strategy, aiming t

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New #PROTAC preprint: In this work, we utilized a non-selective ethyl hydrazide warhead for the selective HDAC6 degradation. Congratulations to co-first authors Daniel @danicious & Irina as well as Felix @fellerflix ! go.shr.lc/4jinjC0

Development of Ethyl Hydrazide-Based Selective Histone Deacetylase 6 (HDAC6) PROTACs | ChemRxiv

Histone deacetylases (HDACs) are promising targets for epigenetic drug discovery. Additionally, targeted degradation of HDACs has emerged as a novel approach in medicinal chemistry and chemical...

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Kicking of the new year with our first publication: Our paper dealing with FEM1B-recruiting HDAC #PROTACs is online in #JMedChem @ACSBioMed. We noticed selective HDAC1-3 degradation. Congrats to Felix @fellerflix, Irina, Martina, Heiko, Svenja and Maria! pubs.acs.org/doi/10.1021/acs…

Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase Degraders

Abstract. Targeted protein degradation (TPD) represents a promising alternative to conventional occupancy-driven protein inhibition. Despite the existence

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The application period for the second cohort of our RTG 2873 @grk2873 is open! We are now recruiting 12 PhD students. For more information see our homepage: grk2873.uni-bonn.de/en. My own project will focus on the development of HDAC #PROTACs. Please RT! grk2873.uni-bonn.de/en/train…

Research Training Group RTG 2873 - University of Bonn

Medicinal Chemistry is a highly interdisciplinary field of research that focuses on the discovery, characterization and development of bioactive tool compounds and drugs. In recent years, the target...

grk2873.uni-bonn.de
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Let´s continue our E3 ligase hopping party! Second stop: DCAF11. The switch from a CRBN to a DCAF11 recruiter converts a selective HDAC6 PROTAC into a pan-degrader. Congrats to first author Felix @fellerflix and my coworkers Heiko, Martina, Irina & Maria! go.shr.lc/3C1jgcA
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Check out our latest preprint on #PHOTACs: Light-activatable PHOTACs enable the optical control of targeted HDAC6 degradation. Huge congrats to Silas @WurnigSilas , Maria, Shiyang @Vincent_SYZ , and our amazing collaborators in the Nowak lab @RPNowak ! go.shr.lc/3ZudhVq

Light-Activatable Photochemically Targeting Chimeras (PHOTACs) Enable the Optical Control of...

Proteolysis targeting chimeras (PROTACs) are heterobifunctional modalities that induce protein degradation via a catalytic mode of action. Photochemically targeting chimeras (PHOTACs) are a subset of...

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