An independent research organisation exploring the links between patient genetics & the design, manufacture & performance of medical devices
Joined January 2020
- Tweets258
- Following223
- Followers239
- Likes95
We have just completed what is, to our knowledge, the largest investigation into the influence of genetics + metal ion release on patient reported outcomes (and metal hypersensitivity) post knee arthroplasty. Results are consistent with our previous work on hips. As part of this Innovate UK funded study, we updated our NHS provided Orthotype clinical test. Some info below.
We will present latest results of NHS study on genetics+metal ion levels in painful knees @ personalized arthroplasty meeting next month, Chicago. We have 4 UK sites and 2 international actively recruiting, study in set up at 4 others. @markbowditch65 would yr unit be interested?
Some nice early results from our Arthrogenex study. Titanium concentrations in patients with nexgen LPS TKRs attending review clinics at 4 to 10 year follow up. Correlation coefficient-0.7, p=0.002
Funding in place for 1750 patients, outcome scores, blood metal ions and genetics.
This will be a really interesting event. @lathamhips will be talking too. Some of the talks will be dynamite. Surgeon, patient, engineering, legal aspects all to be discussed, everyone welcome.
And Newcastle is a great place to visit.
Our colleagues @NHSIAS have their first annual conference on 25th November - great keynote speakers and venue. To register visit: tickets.nthsolutions.co.uk/s…
Our @innovateuk funded @nhs study is showing some important results for patients with #jointreplacements.
The “Arthrogenex”study examines #arthroplasty #genetics and explants.
It is clear that metal release in TKRs is important.
Get in touch if you would like to take part.
We’ve got a ton of results to write up for submission to peer reviewed journals- high impact material. Are there any #arthroplasty research focused trainees or fellows out there who would be interested in helping us out? @AAHKS @bota_uk @BritOrthopaedic @baskonline
We identified HLA allele which places pts at greater risk of painful inflamm responses to CoCr in joint replacements. Image below shows the freq of the allele in populations across the world.
Darker the colour=greater frequency, white no data.
Green = 10-20%
Interesting?
Ref for chart allelefrequenies.net
Ref for stats: The influence of HLA genotype on the development of metal hypersensitivity following joint replacement.
Nature Commun Med. 2022 Jun 24;2:73.
ncbi.nlm.nih.gov/pmc/article…
Another study, another group showing ALVAL rates around 30% in failed #tkrs
ALVAL is clearly a major contributor to unexplained pain.
When is the orthopaedic community going to start discussing this properly?
@EdinburghKnee @KneeUnit @PeltMD @DrLeeRubin
#Unicompartmental knee analysis looking good now.
Key findings so far:
1. Volumetric poly wear of explanted unis is 1.5 > than in total #kneearthroplasty (why?!)
2. Backside surfaces show wear (red), rather than the deformation we tend to see with contemporary #TKR
Ahead of our talk next week @BritishHipSoc , we would like to rerun a poll from last year. #arthroplasty surgeons do you measure blood metal levels in NON MoM arthroplasty patients? @EdinburghKnee @KneeUnit @ExeterHipUnit would you consider resharing to your wide audiences?
28%Never no reason
38%Never, might consider
31%Occasionally
3%Routinely
29 votes • Final resultsUnexplained pain post #arthroplasty
Could it be due to adverse reaction to metal debris? This is determined by metal exposure and genetics.
New test available on NHS combines ICPMS metal levels + genotyping.
@TweetsOrtho @OrthoTwiter
hospital.blood.co.uk/diagnos…
NHS Implant Analysis Conference, May 1st.
The Catalyst (great venue) + Newcastle (great city).
Great speaker line up (see flyer). Should be a really interesting day of discussion.
implantanalysis.nth.nhs.uk/i…
@BritOrthopaedic @baskonline @TheKneeJournal @BritishHip #arthroplasty
