People who drank more coffee had less body fat, less visceral fat, and more lean mass than less-frequent or non-drinkers. The biggest benefit was seen at 5 or more cups per day. And for men, every extra cup per day was associated with a ~10 ng/dL higher total testosterone. Higher coffee intake was also associated with better glucose and insulin regulation in men. This was an observational study, but mechanistic and experimental evidence actually supports coffee's benefits on metabolic and hormonal health. I'm willing to believe there's a real link here rather than draw a conclusion such as "coffee drinkers live healthier lives in general."

Hot water immersion improved vascular function as effectively as zone 2 aerobic exercise. Participants completed three weekly sessions of either 40-minutes in 104°F (40°C) water or 40 minutes of moderate-intensity aerobic exercise. After 12 weeks, both groups showed comparable improvements in flow-mediated dilation (a measure of how effectively blood vessels widen in response to increased blood flow). Research supports similar benefits for other passive heat modalities such as sauna. Neither is a replacement for exercise, but their ability to produce similar improvements in endothelial function is remarkable.

The whole body MRI thing is controversial for obvious reasons. It’s costly & there are a lot of false positives. But I have neurosurgeon friends who tell me they do life-saving surgeries *every month* b/c people got full body MRI merely b/c they curious & found operable issues.

Fighting Frailty: Maintaining Muscle as You Age realexercisescience.com/p/fi… You have an older person in your life, or perhaps you are an older person yourself and you need that push to start strength training.

A MUST-READ! This is probably one of my most important papers where I try to teach how to fish rather than offer fish. How I Read a Clinical Trial Report? BG’s primer for Busy Clinicians. Thank you @JCOOP_ASCO @EthicsdoctorP for the kind invitation. I hope the readers will find this useful. ascopubs.org/doi/10.1200/OP-…

New @ScienceMagazine Why is the heart resistant to cancer? Role of the heart beat! Mechanical force helps protect the heart from cancer science.org/doi/10.1126/scie…

Our Rapamycin & Exercise clinical trial has just been published! The topline result? Rapamycin didn't help. Instead, it may have made things worse. Here's what we found 🧵 onlinelibrary.wiley.com/doi/…

🚨23 years of PSA screening in @NEJM 🚨 👉ERSPC RCT of >162k patients 📅Median 23 year f/u PSA screening lead to... 📉 #prostatecancer mortality by 13% ✅1 death prevented for every 456 men invited for screening or 12 diagnosed w/ PCa 📉Risk of advanced PCa by 34% ⭐️Benefit continues to rise over time as harm-benefit ratio improves 🔗shorturl.at/ajgNN @PCF_Science @PCFnews @urotoday @UrologyTimes @renalandurology @UroOnc