🚨 New pre-print of ours shows Schizophrenia may lead to accelerated Aging in specific physiological systems 🚨 Pre-print - medrxiv.org/content/10.1101/… Schizophrenia doesn’t just affect the mind—it speeds up aging across the body. This study which was led by @ZachHarvanek at @YaleMed uses advanced epigenetic clocks such as Systems Age (SYMPHONYAge) and shows that people with schizophrenia experience accelerated aging in vital systems, especially the ❤️ heart, 🫁 lungs, 💪 metabolism, and 🧠 brain. Interestingly, Early aging was seen from the first psychotic episode—with clozapine use linked to even faster heart and inflammation aging, partly due to smoking 🚬. This analysis, using multidimensional clocks, uncovers unique insights, including shifts in clinical and metabolite epigenetic biomarker proxies for liver and blood health built by @TruDiagnostic. Results survived rigorous testing, showing the importance of proactive health strategies for schizophrenia patients.