@ErgiDuli

Vascular biologist focused on cardiovascular diseases and imaging. Passionate about mentorship in research/medicine.

 Toronto, Ontario
Joined November 2015
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  • Followers31
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Though i’ve seen it first-hand throughout my life, it still amazes me how much our circumstances act as multipliers to our health & illness. The intersection of disease & social determinants doesn’t truly register until you see it daily in the hospital. Really hurts to see it.
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Novartis’ phase III Lp(a)HORIZON trial of pelacarsen failed to prevent cardiovascular events. Vessel dysfunction & inflammation from high lp(a) may not be meaningfully reversed in all patients. Perhaps subgroup analyses may support exploring early (subclinical?) therapy instead
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It truly was a privilege to be born in the 90s and grow alongside tech. We were forced to learn how to ask questions and seek for answers, enjoying the advancements that made work easier as we had slowly built the skills to appraise the outputs. 1-2 decades later… (1/4🧵)
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to AI for social connection. At ages where critical thinking could not possibly have developed, kids are thrust into a world with machines that pretend to be factual, all knowing, and cater to your exact preferences. It pretends to be your friend, companion, or more. (3/4)
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No concern from tech companies. No ability for parents to place restrictions. No political will to govern and set limits. Slow reaction from public schools on curriculum reform. We cannot appreciate the implications of this radical change in human development. (4/4)
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Its astounding how much AI is de-skilling students. In the race to outcompete one another, there is immense incentive to cut corners with AI. This behaviour reinforces a cycle of offloading mental work in exchange for rapid results. Critical thinking is going the way of the dodo.
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Amazing results! My thoughts: (1) most helpful BEFORE plaque builds (2) What is the efficiency of correction? How does % of corrected cells change over time with cell turnover? Might require repeat injection in some cases. (3) cost and accessibility are MAJOR concerns vs statins
Crémieux
@cremieuxrecueilMay 25
Eli Lilly has done it. They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol. That means they'll be able to effectively prevent most heart disease with a single infusion!
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So people have dyslipidemia and most people today are at high risk for heart/vessel disease. Providing this treatment at population scale may bankrupt publicly funded models. Will likely be first reserved for those at incredibly high risk (e.g., familial hypercholesterolemia).
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Proof that #weight loss on medications like #ozempic is not long-lasting, at least without lifestyle changes. Is there a place for these medications for patients? Absolutely! But lifestyle, the largest barrier to sustained weight loss, is constantly left out of this conversation
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Full Article: dom-pubs.onlinelibrary.wiley…
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Podcasts in the health space often misleadingly present possibilities as if they are realities. Without data from human trials, world-class speakers are making millions on a reasonable hypothesis at best. Ask about safety and effectiveness before you risk your money and health.
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Why are Big Pharma/medical doctors not acting on Ivy League professor Dr. Joe Shmoe's billion dollar idea backed by mouse/cell culture data published in famous academic journals. They aren't acting because sufficient data doesn't exist to warrant their action.
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Health Canada Report: canada.ca/en/health-canada/s…
Compensation for publishing papers only increases the risk of fake data. Luckily the incentive is currently capped at a measly $165,000 for a first author publication..... #AcademicTwitter #researchintegrity science.org/content/article/…

Cash bonuses for peer-reviewed papers go global

China's rewards are richest, but many nations now offer incentives for publishing in top journals

science.org
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Do studies which rigorously examine the effect of such incentives on publication quality even exist?
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The irony of this oversight has scientists everywhere sharing the facial expression of this axolotl. #AcademicTwitter #whoops
Benedikt Mandl@b_mandl6 Sep 2022
Nature cover from 2016 left, Science cover from last week right. Watch out, @CellCellPress, you're next! #irresistableaxolotl
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22,000 Canadian #healthcare staff left their employment in July despite 143,400 vacancies. As stressed and overworked employees leave, increased demands on remaining staff may exacerbate the problem. Addressing the looming #healthcarecrisis should be a top priority for leaders.
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#universalhealthcare has never existed for Canadians, at least in my lifetime. Dental, optometry, and some medications are not covered. We already have private clinics. The only "universal" part is that healthcare is universally underfunded and mismanaged hurting all Canadians.
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Today @NASA released the first colour images from @NASAWebb, a beautiful reminder of the vastness of the universe. Millions of people are staring at the sky tonight asking the age old questions, how did we get here and are we alone. Excited to see more tomorrow.#nasa #jameswebb
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