catalysis, reaction discovery, and samoyed sled racing @scrippsresearch. views our own.

La Jolla, San Diego
Joined September 2015
Engle Lab@EngleLab
Aug 2
What's the secret sauce that makes 8-aminoquinoline (AQ) a good directing group?🧐 @avrlisboa's new paper examines w/ 200+ X-ray structures + DFT + competition exps. Spoiler: it's locked in 🔐 sciencedirect.com/science/ar…
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Engle Lab@EngleLab
Apr 28
Together w/ @pengliu_group & #BMSChemistry we inverted the classical selectivity paradigm of organometallic additions to Michael acceptors, achieving enantioselective anti-Michael addition of (hetero)aryl groups under Pd/PhTRAP catalysis. tinyurl.com/3r4yrjd2
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Engle Lab@EngleLab
Feb 25
5+ years developing stable Ni catalysts—and always battling poor solubility! Inspired by the inorg chem literature, our lab w/ a team from @UCSDChemBiochem & #BMSChemistry now report [Ni(C6F5)2] precats w/ superb solubility, stability & convenience. tinyurl.com/yvm7v7yf
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Engle Lab@EngleLab
18 Dec 2025
🔧 In a mechanism🔁method tour de force, @avrlisboa & team show that a flexible directing group dramatically improves Pd-catalyzed functionalization of hindered olefins, leading to >115× rate boost and expanded scope. @ChemRxiv tinyurl.com/34rx6w9v @pengliu_group @EnamineLtd
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Engle Lab@EngleLab
19 Nov 2025
The newest chapter in air-stable Ni(0): Ni(DQ)2 @ChemRxiv pre-print: tinyurl.com/yhzufye8 @HarryHe88239850 @SongLinLab #BMSChemistry
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Engle Lab@EngleLab
21 Oct 2025
C(sp3)-C(sp3) couplings w/o radicals? 🧐 We introduce alkyl-9-BBN reagents to the 3-component coupling party 🎉, enabling access to new encoded cyclooctene monomers for ROMP 🧵 w/ @pengliu_group @GuteGroup @ChemRxiv: tinyurl.com/4fh49ke5 🧪 #TeamNickel #PolymerChem
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Engle Lab@EngleLab
4 Sep 2025
What a great thrill and honor to be recognized by the @ACSGCI Green Chemistry Challenge Award this year. Member of the lab past and present, together with collaborators from #BMSChemistry and @UCSDChemBiochem, traveled to @theNASciences in DC this week for occasion. #teamnickel
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Engle Lab@EngleLab
29 Jul 2025
One week to go! 2025 OM Bootcamp @scrippsresearch kicks off on Aug 4th, 8 am PT. Welcoming participants in-person or over zoom, synchronous or asynchronous, low-spin or high-spin. Register👇 forms.gle/hADxFitVnSJfh2uk6
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Engle Lab@EngleLab
30 May 2025
atropisomers? positional isomers? both? We present beautiful and curious class of molecules today in @ChemRxiv. 🧐🪞 tinyurl.com/yxyb5rup @ASimlandy @0iTurki @pengliu_group
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Engle Lab@EngleLab
5 May 2025
Unexpected reactivity → simple access to dihydro-1-benzazepines! Now out in TL 🎉 Part of a special issue celebrating @SongLinLab's Tetrahedron Young Investigator Award 🏅 Big thanks to undergrad Letian + the whole team 🙌 tinyurl.com/2p5pd46h
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