ALT Two figures showing the effect of retatrutide on body weight. Panel A shows the percent change in body weight from baseline to week 80 (controlled for type I error). Panel B shows the percentage of patients with reductions in body weight of 15% or more and 30% or more (controlled for type I error), along with the percentage of patients who reached the body-mass index targets of less than 30 or less than 25 and the waist-to-height ratio target of less than 0.5 (not controlled for type I error) at week 80 for the treatment-regimen estimand.

ALT Two figures showing the effect of retatrutide on health outcomes. Panel A shows the percent change in lipid measures, the percent change in the high-sensitivity C-reactive protein (hsCRP), and the change in systolic blood pressure (SBP) in the overall trial population (controlled for type I error except for low-density lipoprotein [LDL] and high-density lipoprotein [HDL]). Panel B shows the percentage of patients with normoglycemia, prediabetes, and type 2 diabetes at week 80 among the patients who had prediabetes at baseline for the treatment-regimen data-points set.