@ellman_lab

Official Twitter account of the Ellman Lab at Yale University

ellman.chem.yale.edu
Joined July 2020
  • Tweets147
  • Following224
  • Followers1.7K
52Media
The Ellman group explores and develops new catalytic transformations and methods to facilitate the synthesis and discovery of pharmaceuticals. The lab is a collaborative and inclusive community of scientists and welcomes researchers with diverse backgrounds and experiences.
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New year, new group photo! 📸 Stay tuned to see more from the Ellman lab in 2025! 🧪💊
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We are pleased to share our latest collaboration with Dr. Chris Gnamm at Boehringer Ingelheim on the properties of diverse sulfilimines relevant to drug discovery. Amazing work Nate and Zach! 🤩 doi.org/10.1021/acs.jmedchem…

Sulfilimines from a Medicinal Chemist’s Perspective: Physicochemical and in Vitro Parameters...

Abstract. While sulfoximines are nowadays a well established functional group for medicinal chemistry, the properties of sulfilimines are significantly les

pubs.acs.org
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Warm welcome to our new first years: Isaac, Owen, Emma, and Justin! Stay tuned to see all the amazing things they accomplish! 🤩🧪⚛️
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Exciting results out now in @ACSCatalysis! Third year Ramsey and colleagues have developed a C-H bond sequential addition to dienes and imines with interesting mechanistic studies. 🟥+🔵+🔶 Check it out below: pubs.acs.org/doi/10.1021/acs…

C–H Activation and Sequential Addition to Dienes and Imines: Synthesis of Amines with β‑Quaternary...

Abstract. A Rh­(III)-catalyzed sequential C–H bond addition to dienes and in situ formed aldimines was developed, allowing for the preparation of otherwise

pubs.acs.org
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We are hiring a director for our Catalysis and Separations Core to further synthetic chemistry research by managing instrumentation and helping early career researchers perform experiments in the Core (csc.yale.edu). Learn more and apply at apply.interfolio.com/156577.
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Big congrats to @jihyeonyeo on her first first-author paper, and for driving this awesome project!
Ellman Lab@ellman_lab1 Nov 2024
Thrilled to share our latest work, by @jihyeonyeo and @JosephPTassone, out in Org Lett now! ✨ We harness isocyanates for the synthesis of α-aliphatic quaternary amides with a Cp*Co(III) catalyst. Check it out below 👇🏼 pubs.acs.org/doi/10.1021/acs…

Synthesis of α‑Quaternary Amides via Cp*Co(III)-Catalyzed Sequential C–H Bond Addition to 1,3-Die...

Abstract. The synthesis of sterically congested amides was accomplished via Cp*Co­(III)-catalyzed sequential C–H bond addition to 1,3-dienes followed by am

pubs.acs.org
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Thrilled to share our latest work, by @jihyeonyeo and @JosephPTassone, out in Org Lett now! ✨ We harness isocyanates for the synthesis of α-aliphatic quaternary amides with a Cp*Co(III) catalyst. Check it out below 👇🏼 pubs.acs.org/doi/10.1021/acs…

Synthesis of α‑Quaternary Amides via Cp*Co(III)-Catalyzed Sequential C–H Bond Addition to 1,3-Die...

Abstract. The synthesis of sterically congested amides was accomplished via Cp*Co­(III)-catalyzed sequential C–H bond addition to 1,3-dienes followed by am

pubs.acs.org
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Thank you so much to everyone at BMS for taking the time out to organize this fantastic event! I connected with so many inspiring women who shared their stories and gave me invaluable advice for my journey. I also received many helpful suggestions and questions during my poster.
Ellman Lab@ellman_lab28 Oct 2024
Last Friday, @shivanipat18 and @jihyeonyeo had a wonderful opportunity to present a poster and flash talk at the @bmsnews Women in Chemistry Outreach Day! Thank you to all the amazing individuals at BMS for funding and organizing this event! #WomeninChem 👩🏽‍🔬
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Last Friday, @shivanipat18 and @jihyeonyeo had a wonderful opportunity to present a poster and flash talk at the @bmsnews Women in Chemistry Outreach Day! Thank you to all the amazing individuals at BMS for funding and organizing this event! #WomeninChem 👩🏽‍🔬
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Excited to share our latest work on the preparation of phosphonate-substituted diketopiperazines from α-amino amides by Rh(III)-catalyzed N-H functionalization. Congratulations on this fantastic work to fifth year grad student Jenna and undergrad Emily! pubs.acs.org/doi/10.1021/acs…

Synthesis of Monodehydro-Diketopiperazines Enabled by Cp*Rh(III)-Catalyzed Amine-Directed N–H...

Abstract. A two-step, diversity-building sequence to prepare monodehydro-diketopiperazines from readily accessible materials is reported. Rh­(III)-catalyze

pubs.acs.org
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Replying to @ellman_lab
Huge thanks to my amazing friend and coauthor Na Yeon Kwon for all her work helping to get this paper out!
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The lab previously reported the 1st catalytic enantioselective S-alkylation of sulfenamides by metal catalysis and now discloses organocatalytic enantioselective S-alkylation to provide useful S(IV) and S(VI) pharmacophores. Check it out below: onlinelibrary.wiley.com/doi/…

Enantioselective S‐Alkylation of Sulfenamides by Phase‐Transfer Catalysis

A general phase-transfer catalyst (PTC) mediated enantioselective alkylation of N-acylsulfenamides is reported. Enantiomeric ratios up to 97.5 : 2.5 and an average yield of 94 % across a broad scope...

onlinelibrary.wiley.com
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It's finally time to share this: my long time obsession with inherently chiral medium-sized rings now has a catalytic, enantioselective method. After a number of attempts, we developed a strategy based on choosing the maximally preorganized disconnection, which... [1/3]
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Ellman Lab retweeted
Herzon Lab@HerzonLab27 Aug 2024
Congratulations to Prof. Seth Herzon for winning the ACS Award for Creative Work in Synthetic Organic Chemistry! Seth joins fellow @YaleChem colleagues Profs. Jon Ellman (2021) and Scott Miller (2016) as a recipient of this award! cen.acs.org/acs-news/ACS-ann…

ACS announces its 2025 National Award winners

The ACS National Awards encourage the advancement of chemistry in all its branches, support research endeavors, and promote the careers of chemists

cen.acs.org
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Ellman Lab retweeted
Herzon Lab@HerzonLab28 Aug 2024
Congratulations to Vaani Gupta (G3) for receiving a Harry H. Wasserman Graduate Research Fellowship award! ✨️✨️
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Very excited to share our latest work by Ellman lab alum Dr. Andrew Streit and second year Julia in collaboration with Matt Simon's lab at Yale! Check out this work on mapping small molecule transcriptome interactions below: 🧬 pubs.acs.org/doi/10.1021/acs…

Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide

Abstract. We report the development of Tether-seq, a transcriptome-wide screen to probe RNA–small molecule interactions using disulfide tethering. This tec

pubs.acs.org
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Yesterday, @Maria_AVargas represented the Ellman lab at an invited poster session in Cambridge with the 2024 Chemistry Spotlight @pfizer! Check out her amazing work on visible light-mediated diastereoselective epimerization on our website! 👩🏻‍🔬🧪 #WomenInSTEM
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Congratulations to third-year student @shivanipat18 on receiving the Women Chemists Committee and Eli Lilly Travel Award! 🎊 Shivani shared her work the enantioselective synthesis of sulfoximines at #ACSFall2024!
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Last week, I attended #ACSFall2024 and was able to share my work with so many wonderful scientists! Thank you to @AcsWcc and @EliLillyandCo for supporting me! I am in awe of all the amazing women I met through the WCC. So grateful for all the fantastic scientific conversations!
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