Lessons for the revolution Medicine doesn't have a vital sign for aging yet, and proving one is possible had to come first. Cholesterol and A1C are useful because they measure something specific. Nothing does that for aging, which is why Barzilai's centenarian research and the TAME trial were really arguments that aging is a single measurable condition before anyone could build a test for it. One well-aimed drug can move several hallmarks of aging at once. Targeting a single hallmark, like autophagy or mTOR signaling, changes the others too, which is why a handful of existing drugs already show benefits across diseases that look medically unrelated. Predicting biological age and proving a treatment changed it are different jobs. Methylation and proteomic clocks estimate how old you biologically are. FAST is built to find the much smaller set of biomarkers that visibly shift within months of an intervention, which is what a clinical trial, or a clinic, actually needs. None of this requires waiting, and the FDA may not be the obstacle it once was. Several drugs already prescribed for other conditions appear to act on the biology of aging directly, and behavior — exercise, sleep, diet, social connection — remains the surest lever available while the rest catches up. youtube.com/watch?v=HbeGjwCw…

Very well written article on my FAST project with @Danbelsky “We're asking two things: What is the best biomarker for aging and also changing within a year of treatment?” wewillcure.com/insights/long…

“Aging has biology. This biology drives diseases” edition.cnn.com/health/can-a…

Check out the latest on Geroscience from my reecnt interview for the academy

Please join us for an exciting afternoon of Geroscience! We are just one week away from the first Biology of Aging T32 National Scholars Symposium, and we hope you will join us! Biology of Aging T32 National Scholars Symposium Date: September 2, 2026 Time: 12-3pm Central Location: Zoom Registration: uwmadison.zoom.us/meeting/re… The symposium will bring together scholars from across the country to share their research spanning a broad range of topics in the biology of aging. We are excited for an afternoon of engaging presentations, discussion, and opportunities to connect with others across the aging research community. Please feel free to share this invitation with colleagues and trainees who may be interested.