@EdyKim5

@BrighamWomens https://xitter.cf/t.co/2VsOqyyzzE @HarvardMed Physician-Scientist. Translational wet/dry lab on the immunology of pulm fibrosis & cardiac arrest. Immigrant

 Brigham & Women's / HMS
edykimlab.com
Joined October 2018
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My reflections on how COVID put the "physician" into phys-scientist. Started my lab then left turn into open-access COVID clinical guidelines. For all of us, a formative time, but hard to say what form... elifesciences.org/articles/7…
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Huge thanks to @waikarss, @EdyKim5, and @NIDDKgov, without whom this would not have been possible.
Mass General Brigham Research@MGBResearchNews26 Sep 2025
In a new study, researchers from @MGBKidneys and colleagues investigate vitamin D and acute kidney injury prevention. The study was published in @JCI_insight. Read more: insight.jci.org/articles/vie… @DavidLeaf9
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In a new study published in @ScienceTM, researchers from @BrighamAnes @MGHanesthesia and colleagues found new insights into preventing brain injury after cardiac arrest. Read more: massgeneralbrigham.org/en/ab… @EdyKim5 @FumitoIchinose doi.org/10.1126/scitranslmed…
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Diverse natural killer T cells regulate innate immunity to improve neurological outcomes and survival after cardiac arrest @ScienceTM @EdyKim5 science.org/doi/10.1126/scit…
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Moving to edykimlab.bsky.social
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Our review paper led by Alene Saavedra, outlining several nuances that emerged for RA-ILD treatment in the recent ACR/CHEST guideline - in particular AZA and MMF We also review all trial evidence - only 3 RCTs (n=217 total!) have enrolled RA-ILD pts! link.springer.com/article/10…

Treatment of rheumatoid arthritis-associated interstitial lung disease: An appraisal of the 2023...

Current Treatment Options in Rheumatology - To summarize the current treatment landscape of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) in the context of the recent 2023...

link.springer.com
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Our latest study investigating risk factors for RA-ILD subtypes, led by Dr Gregory McDermott We systematically identified/subtyped all RA-ILD cases and RA-noILD controls in the @BrighamWomens RA Sequential Study and @MassGenBrigham Biobank (n=3328) acrjournals.onlinelibrary.wi…

Impact of Sex, Serostatus, and Smoking on Risk for Rheumatoid Arthritis–Associated Interstitial...

Objective Rheumatoid arthritis–associated interstitial lung disease (RA-ILD) includes multiple subtypes with varying histopathology, prognosis, and potential treatments. Limited research has invest...

acrjournals.onlinelibrary.wiley.com
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Our latest one is out @Nature ! We found an aberrant immune epithelial progenitor niche drives post viral lung inflammation and fibrosis #LongCovid. We also pointed out potential therapeutics. nature.com/articles/s41586-0… Shout-out to @hnarasim23 and @wqian1016 @PeterChenMD @zangcz

An aberrant immune–epithelial progenitor niche drives viral lung sequelae

Nature - CD8+ T cell–macrophage interactions have a central role in impairing alveolar regeneration and driving fibrotic sequelae after acute viral pneumonia in a mouse model of long COVID.

nature.com
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High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus - published now in @NatureComms @BrighamResearch nature.com/articles/s41467-0…

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus

Nature Communications - Here, the authors use SNP-seq to screen 87 lupus risk loci for functional non-coding variants. Validation at one locus identified a risk variant through which enhanced...

nature.com
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1. Introducing a new thread: super basic lung pathology for PGY1s, with arrows. If you are a PGY1, leave a comment and I will tag you in a future post. A hamartoma is a disorganized mix of overgrown normal tissues (in their normal location) that creates a mass. Good news: they are benign! #pathology #pulmpath #tweetorial #pathtweetorial #sblppgy1
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Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress cell.com/cell/fulltext/S0092…
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Have you wondered how Yamanaka found the 4-gene combination to transform somatic cells to stem cells? The # of possibilities are greater than - 20,000^4. I did this yesterday & read the original paper. What a journey & pure joy it was! Here’s how he did it. ⌛️
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Our review of immune axes in lung fibrosis @CellCellPress is for the immunologist or cell biologist without a clinical background but reflects our lab's physician-scientist approach. 1/7.
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In conclusion we echo the call of many others for translational insight into the natural history of lung fibrosis: earliest stages, acute exacerbations and integration of genomics with immunophenotyping (and mechanism!). 6/7
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Collab led by Mari Kamiya (Kim lab), Hogaboam lab, Beth Moore lab, @leticiakawano, Joyce Lee (CU), @FanZhang_Jessie, @jeffsparks, Chip Merriam, co-senior @wm_oldham also of @BWHPulmCCM @BrighamResearch. 7/7
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I highly recommend this leadership & management training program for postdocs & junior faculty!
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CXCL13 shows up prominently in T cells in autoimmune tissues and tumors. Human Tfh and Tph cells produce lots of CXCL13, yet its regulation is pretty unclear. With beautiful CRISPR screens by @jaehyukchoimd, @CalvinYLaw_, we found a few key factors... nature.com/articles/s41586-0…

Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus

Nature - Insufficient AHR activation has been suggested in SLE, and augmenting AHR activation therapeutically may prevent CXCL13+ TPH/TFH differentiation and the subsequent recruitment of B cells...

nature.com
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