To procalcitonin or not to procalcitonin? 🆕💥🟢Retrospective cohort study of adult patients with severe CAP 12 hospitals between November 2022 and June 2025 PCT testing was associated with fewer antibiotic days (mean 6.9 vs 7.4 days adjusted mean difference, −.5 days, 95% CI: −.8, −.3), particularly in stable (mean 6.6 vs 7.3 days, adjusted mean difference, −.8 days, 95% CI: −1, −.1) #idxposts cambridge.org/core/journals/…

🔥It's published 🔥 The first ever RCT combination therapy for Stenotrophomonas maltophelia infections Efficacy of combination therapy with minocycline for treating Stenotrophomonas maltophilia infections 🔺Adjunctive minocycline did not significantly reduce 28-day-mortality (n = 24/55[43.6%] vs n = 22/57[38.6%], P = 0.590) #IDXposts @drgabx academic.oup.com/jacamr/arti…

Dear fanatic followers, Do you think my AI-generated graphics are terrible? Someone on Bluesky suggested I stop using them! My goal is to simplify complex topics visually rather than just reproducing original figures or presenting study results as text. What do you think? Honest feedback is welcome! #idxposts

Prior Antibiotic Exposure and Subsequent Resistance in the Individual Patient 🆕💥🔴Progressing From Association to Causation: Examining Prior Antibiotic Exposure and Antimicrobial Resistance Across 3 US Health Systems Using Causal Machine Learning Prior antibiotic exposure was consistently associated with increased same-class nonsusceptibility across antibiotic classes and health systems, paralleling higher rates of microbiologically inactive empiric therapy #idxposts academic.oup.com/cid/article…

Mind blowing! 🔺Prior fluoroquinolone exposure was associated with increased nonsusceptibility by 11.9 and 12.6 percentage points at the primary sites (MGB, Stanford) and 8.6 points in validation (BIDMC) (all P < .001). 🔺Positive associations occurred for all 7 classes at all sites (sulfonamides indeterminate at Stanford), strongest at 30 days and attenuating through 365 days