@EdBiophysics

Edinburgh Single-Molecule Research Group

horrockslab.org
Joined September 2021
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  • Following284
  • Followers228
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Congrats @haresh_bhaskar_ on passing his viva!!! Thanks to @AleksPonjavic and Ewen Calder for examining!
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Thanks for sharing, great to see this out!
Chemistry Edinburgh@EdinburghChem
28 Aug 2025
Scientists from @EdinburghChem and the Institute for Regeneration and Repair (IRR Chemistry Hub) at the The University of Edinburgh have developed an innovative method to detect small biological particles in blood samples.
Image showing an extracellular vesicle detected by labelled antibodies (green and red fluorophores) against surface proteins.

ALT Image showing an extracellular vesicle detected by labelled antibodies (green and red fluorophores) against surface proteins.

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Thank you @MathewHHorrocks for such a cute gift! And to @TempChiao_ for making this first paper possible 😍 To this and many more 💃🏻
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Check out our latest publication! VISTA 👀 offers a specific and sensitive tool for EV characterisation, showing its potential to detect EVs in neat biofluids too, without the need for EV isolation. So happy to see this one finally out! 🤗onlinelibrary.wiley.com/doi/…
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Finally we can share our VISTA 👀 technique to characterise EVs using single-molecule confocal microscopy! Get in touch if you’d like to hear more about 🤗 biorxiv.org/content/10.1101/…

Fluorescence Characterization of Extracellular Vesicles using Single-Molecule Confocal Microscopy

Extracellular vesicles (EVs) are small, membrane-bound particles released by cells into the extracellular environment. They play a pivotal role in cell communication and have recently gained promin...

biorxiv.org
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Thanks for highlighting our work, excited to share this project!
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Grand first day at #synuclein2025 meeting starting with amazing talks and a visit to @ZoologyMuseum. Looking forward to exciting science in the next few days! 😍👌
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Check out our new single-molecule liposome assay for studying membrane disruption! Well done to all involved. @EdinburghChem @LeverhulmeTrust onlinelibrary.wiley.com/doi/…
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Had a great time at the IRR ChemHub event, with PI flash talks and facility managers talks. Thank you everyone for joining and looking forward to seeing you all at our next event 😊 @EdinUni_IRR @EdinburghChem
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Great memories from the 6th Japan-UK #Neuroscience Symposium. What a wonderful event at #Awaji 🇯🇵 Thank you so much for all. See you in 🇬🇧 👏 @KingsIoPPN @KingsCollegeLon @UKDRI @cardiffuni @NagoyaUniv @juntendo_univ @osaka_univ_e @The_MRC @AMED_officialJP
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Check out out new paper on live super-resolution imaging in cells! onlinelibrary.wiley.com/doi/… @haresh_bhaskar_ @EdinburghChem @EdinUni_IRR

Super‐resolution imaging of proteins inside live mammalian cells with mLIVE‐PAINT

Super-resolution microscopy has revolutionized biological imaging, enabling the visualization of structures at the nanometer length scale. Its application in live cells, however, has remained...

onlinelibrary.wiley.com
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Great Xmas night out with the lab, amazing ceilidh dancing skills everyone and such a cardio session 💃🏻
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Interested in genetic engineering and following individual molecules with microscopy? Come engineer the next-generation microbial cell factories in Leeds with @eszter_cs and @ryanfseipke! findaphd.com/phds/project/bu…

Building a fluorescent toolbox for exploring translation in Vibrio natriegens at University of...

PhD Project - Building a fluorescent toolbox for exploring translation in Vibrio natriegens at University of Leeds, listed on FindAPhD.com

findaphd.com
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Wondering about the link between pollution and dementia? Apply for this PhD position in our lab to research this topic with us! 🧪🔬
Mathew H Horrocks@MathewHHorrocks
10 Dec 2024
PhD available! Interested in using single-molecule biophysics to investigate the link between pollution and dementia? findaphd.com/phds/project/ea…
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Congrats to @marc311998, our visiting PhD student from @PPMC_UAB on his Bowler Travel Bursary award ✈️ offered by @ParkinsonsUKSco 😊 Special thanks to the judges for such a hard task! #asynuclein #Parkinson
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@EdinburghChem @EdinUni_IRR
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Congrats to @haresh_bhaskar_ for winning a prize for his presentation at Super-Resolution in the North! Thanks for organising a fantastic event @AleksPonjavic. @EdinburghChem @EdinUni_IRR
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Congrats to Dr Konieczna (@KoniecznaZ), who passed her PhD viva today! First member ever of the ESMB group. Well done, we are proud of you! 🤩 Thanks to the examiners @PPMC_UAB and Anita @EdinburghChem @EdinUni_IRR #peptides #PhDone
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Replying to @beccysaleeb
@beccysaleeb & @Noe_pelehidal representing ESMB at the 50th @scotmicro Symposium today in Glasgow. Organisers did a wonderful job putting together such a varied and interesting programme 😍 Thank you! 🙏#ScotMicro2024 #Microscopy #superres
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@EdinburghChem @EdinUni_IRR
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New paper! We have confirmed Francis Crick's 1984 hypothesis on memory preservation. 🧠 Using super-resolution microscopy, we visualised protein lifetime in super-complexes isolated from the brain, looking at structure and turnover! @EdinburghChem elifesciences.org/articles/9…

Sequential replacement of PSD95 subunits in postsynaptic supercomplexes is slowest in the cortex

PSD95 supercomplexes maintain long-term stability through gradual subunit replacement, with the slowest turnover in cortical synapses associated with memory storage.

elifesciences.org
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