Scale up from clinical batches to commercial supply is a separate engineering problem entirely. #Biotech #Manufacturing

Statistical significance and clinical meaningfulness are different questions. Trials answer the first one. #ClinicalTrials

A single arm study with a historical control answers a narrower question than most headlines suggest. #ClinicalTrials

Bid stacking looks like support until the moment it is not there. Not financial advice. #Trading

A stock that only goes up on press releases is telling you where the demand comes from. Not financial advice. #Markets

Biomarker driven enrichment makes a trial more likely to succeed and the eventual market smaller. #Biotech #ClinicalTrials

Enrollment pace is one of the quietest tells in clinical stage biotech. A trial that fills fast usually means investigators believe in it. #ClinicalTrials

Dose selection carried forward from phase two is one of the most consequential decisions in a program. #DrugDevelopment

Trial registries are public. Comparing what was registered to what was reported is a five minute exercise. #ClinicalTrials #DueDiligence

Development timelines in biotech are measured in years and communicated in quarters. #Biotech #DrugDevelopment

A conference presentation is not a catalyst. It is a calendar entry with good lighting. Not financial advice. #Biotech

Toxicology findings in animals do not always translate. They also do not get ignored. #Biotech #Preclinical

Contract research organisations run most trials. Their performance is a real variable and rarely disclosed. #ClinicalTrials

Route of administration changes adherence, which changes real world outcomes, which changes the commercial case. #Biotech

Formulation work is unglamorous and decides whether a molecule is a product. #Biotech #Pharma

Subgroup analyses are where good trials go to be misinterpreted. #ClinicalTrials #Biostatistics

Reading a company's competitors teaches you more than reading the company again. Not financial advice. #DueDiligence #Investing

Imaging endpoints are objective and still depend heavily on who reads the images. #ClinicalTrials

Chemistry manufacturing and controls stops more programs than efficacy does, and gets a fraction of the attention. #Biotech #Pharma

Every drug that works has a population where it does not. Finding that boundary is the whole job. #Biotech #Medicine