@DukeWestLab
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The West lab identifies pathogenic mechanisms underlying neurological diseases like Parkinson’s to develop new therapeutics that block disease progression
Joined March 2021
- Tweets34
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West Laboratory retweeted
Work led by Arpine Sokratian in Andy West's lab unveils the structural underpinnings of alpha-synuclein pathogenicity: Mouse alpha-synuclein fibrils display unique features compared to humans, impacting disease models. More here: doi.org/10.1126/sciadv.adq35…
West Laboratory retweeted
Interesting: @DukeWestLab @LashuelLab & collaborators report the first atomic structure of mouse α-synuclein fibrils, but find altered packing arrangements,⬇️hydrophobicity, &⬆️fragmentation sensitivity & weak immunological responses (vs human a-syn)
science.org/doi/10.1126/scia…
West Laboratory retweeted
New paper from @DukeWestLab et al present an ultra-sensitive version of a SiMOA (single-molecule array assay) for measures of LRRK2 kinase activity in serum linking #Parkinsons severity to peripheral inflam.; Accurate measures of pT73-Rab10 to total Rab10
molecularneurodegeneration.b…
West Laboratory retweeted
#Cover: Gut mucosal cells transfer α-synuclein to the vagus nerve: buff.ly/3RyFyaH
The image shows α-synuclein (red) emerging from an enteroendocrine cell (green) onto a vagal neuron (turquoise).
@DukeHealth
#Gastroenterology #Neuroscience
West Laboratory retweeted
New research from @DukeWestLab & collaborators reports that anionic nanoplastic contaminants potently precipitate the formation & propagation of #Parkinsons-associated α-synuclein protein fibrils, through a high-affinity interaction NAC domains in α-syn
science.org/doi/10.1126/scia…
Nanoplastics Create an Environment for Parkinson’s To Develop, Study Suggests | Technology Networks technologynetworks.com/appli…
Congrats to Jon Lin!!, Honors undergraduate researcher who will be starting his program in data science in a few weeks @NCState
Recent Duke Neuroscience honors Graduate, Deney Li, researcher extraordinar, will be heading our @MichaelJFoxOrg biomarker research project as a post-bacc! So happy she can stay on!
Our undergrad researcher Grace, headed for @UW_MSTP , go get em!
Congrats to Nicole!!, our post-doc headed to @VividionRx shake up the Early Discovery program!
Congratulations to Zhiyong!!, Our famous K99/R00 awardee and incoming tenure track Assistant Professor in Cell Biology, #UABSOM #GoBLAZERS
Shoutout to our grad student Samuel Strader publishing an excellent review!
The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease portlandpress.com/biochemsoc…
Congrats to the West Lab 2023 Graduates!! Moving on is bittersweet for us, but what a great job in the lab, you will be missed 🥲
West Laboratory retweeted
Interesting new commentary from West and Schwarzschild on LRRK2 inhibitors for PD and their journey through the pharma "Valley of Death." #LRRK2 #Parkinsons @DukeWestLab
movementdisorders.onlinelibr…
West Laboratory retweeted
Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase biorxiv.org/cgi/content/shor… #bioRxiv
West Laboratory retweeted
@ASAP_Research @AsapLiddle retreat wrapped up today…what great science was discussed 🤓😍!!!
West Laboratory retweeted
College life in a research lab: two students @DukeNeuro weigh in on how they got here, what they're learning and where they hope to go bit.ly/3fqfZZ4 @DukeWestLab
