Duber

#Susac's syndrome is a rare immune-mediated endotheliopathy characterized by a classic triad of #hearing loss, #retinal vaso-occlusive disease, and #encephalopathy. It was first described by American neurologist John O. Susac, who in 1975 saw a young woman with a previously unreported clinical triad of encephalopathy (“personality changes and paranoid psychosis”), branch retinal artery occlusions, and deafness. This patient was presented to him at a conference in Albany, New York. Shortly thereafter, John Selhorst referred a 40-year-old woman with an identical set of clinical findings. They published these cases in 1979 as #microangiopathy of the #brain and #retina and since then there have been many additional patients reported. 📸 John O. Susac, MD (1940–2012) holding a cut-away model of the human brain in which he discovered Susac’s syndrome. 📸 Susac JO. Susac's syndrome: the triad of microangiopathy of the brain and retina with hearing loss in young women. Neurology. 1994;44(4):591-593. doi.org/10.1212/wnl.44.4.591 #WorldHearingDay #WorldHearingDay2025