@Drewes_Lab

Microbiologist with an interest in cancer, immunology, and spatial biology

 Baltimore, MD
Joined July 2022
  • Tweets63
  • Following60
  • Followers70
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#bacteria cause mutations in #cancer - but only if they stick to host cells. Brilliant study from @LarsVereecke lab in @Nature: nature.com/articles/s41586-0… Our accompanying perspective with @kyannaouyang: nature.com/articles/d41586-0… Lots of implications for new CRC prevention approaches!
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“Every first draft is perfect because all the first draft has to do is exist.” - Jane Smiley
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#Twinning in lab today!
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Dr. Julia L. Drewes (@Drewes_Lab), Dr. K. Leigh Greathouse (@CancerMicrobes), and Dr. Marios Giannakis @GiannakisLab presented their research on the microbiome/biological basis of early-onset GI cancers during the #RueschSymposium on Nov 17th, 2023 at @LombardiCancer.
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📢CALLING ALL MICROBIOLOGISTS📢 Do you use CFU assays? Here is a new high-throughput, low-waste viability assay for microbes All you need is agar media, pipette tips and a standard camera 🧫📸 nature.com/articles/s41564-0… @meyerct6 @danastamo
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My department is hiring an Assistant Professor in bacterial pathogenesis! Come join @GWLiechti and me and the rest of our supportive colleagues in Bethesda. higheredjobs.com/details.cfm…
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The joys of writing grants for the NIH
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Out today in @cellhostmicrobe, @LDzierozynski, @DrCindySears, and I comment on shaping of the gut microbiome by host genes. @HopkinsMedicine @JHMed_ID @bloombergkimmel sciencedirect.com/science/ar…
model figure from the linked article depicting a man with a colon. From the colon are 2 callout boxes, one with DNA and the other with bacteria. Between the 2 are bidirectional arrows, and then an arrow from both to a box listing microbiome functional outputs.

ALT model figure from the linked article depicting a man with a colon. From the colon are 2 callout boxes, one with DNA and the other with bacteria. Between the 2 are bidirectional arrows, and then an arrow from both to a box listing microbiome functional outputs.

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Julia Drewes retweeted
Ardem Patapoutian@ardemp
5 Sep 2023
Remarkable! According to this paper humans almost became extinct: "Results showed that human ancestors went through a severe population bottleneck with about 1280 breeding individuals between around 930,000 and 813,000 years ago." h/t @LippiLab science.org/doi/10.1126/scie…

Genomic inference of a severe human bottleneck during the Early to Middle Pleistocene transition

A severe bottleneck that brought human ancestors close to extinction occurred between about 930 and 813 thousand years ago.

science.org
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Julia Drewes retweeted
Eric Topol
@EricTopol
10 Aug 2023
It seems like sci-fi. They engineered bacteria to detect colon cancer. science.org/doi/full/10.1126… @ScienceMagazine #synbio
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Julia Drewes retweeted
Shen Lab@ShenLabTufts
8 Aug 2023
Very excited to share this beautiful story by @ShailabShrestha describing his surprising discovery that cell division in C. difficile occurs via a mechanism distinct from previously characterized bacteria. Done in collaboration with the amazing @SGribaldo & Najwa Taib. 1/9
Shailab Shrestha@shailabshrestha
8 Aug 2023
So excited to finally share this work!! We found an unexpected repurposing of canonical division enzymes during the evolution of endospore formation and some surprisingly unique aspects of cell division in C. difficile. Check out our preprint: rb.gy/j5uvc
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Out in @NatureCancer: @fyzashaikh , @DrCindySears , and I review the latest advancements in microbiome research with potential therapeutic impacts for cancer. nature.com/articles/s43018-0…

Understanding the mechanisms and translational implications of the microbiome for cancer therapy...

Nature Cancer - Sears and colleagues discuss the latest advances in the understanding of host and microbiota mechanisms involved in the relationship between the microbiome and cancer and emerging...

nature.com
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Major, fatal errors found in the data and methods of a 2020 paper in @Nature, including millions of reads mis-identified as bacteria. The "cancer microbiome" in this study was simply not there. @abrahamgihawi @elapertea @YuchenGe1 @JenniferLu717 biorxiv.org/content/10.1101/…

Major data analysis errors invalidate cancer microbiome findings

We re-analyzed the data from a recent large-scale study that reported strong correlations between microbial organisms and 33 different cancer types, and that created machine learning predictors with...

biorxiv.org
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📍A new #COVID wave is clearly emerging in US, all while immunity levels are waning and new boosters aren’t even close to arriving yet. You don’t need another original Omicron winter wave to cause disruption—Delta variant killed a lot in Aug-Oct 2021. Plus don’t risk #LongCovid.
JWeiland@JPWeiland
27 Jul 2023
Wastewater numbers from Biobot.io are now rising in all regions.⬆️ Almost double where they were in mid June. From these data, my case estimates: 🔸365,000 new cases/day⬆️ 🔸1 in every 900 people were infected today 🔸1 in every 90 people currently infected.
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Greengenes2 unifies microbial data in a single reference tree nature.com/articles/s41587-0…

Greengenes2 unifies microbial data in a single reference tree

Nature Biotechnology - A comprehensive microbial resource reconciles genomic and 16S rRNA data in a single tree.

nature.com
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We Are Hiring! The Department of Microbiology at Harvard Medical School (micro.hms.harvard.edu/) invites applications for a tenure-track position at the rank of Assistant or Associate Professor. Please spread the word! academicpositions.harvard.ed…
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My lifelong dream has been to use machines to accelerate discoveries in biology. @cellhostmicrobe Using AI we discovered antibiotics in Neanderthals and Denisovans, our closest hominid relatives. Molecular de-extinction opens new avenues for drug discovery cell.com/cell-host-microbe/f…

Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning

Maasch and Torres et al. described a machine learning model that identifies antimicrobial peptides within extinct human proteins. Molecular de-extinction shows promise in drug discovery by reintrod...

cell.com
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I mean, there are worse locations for dinner at a conference! #DDW2023 – at Chicago, IL
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Science is hard. Good research makes you feel stupid. You're inadequate for the task at hand. How else would it be? You're pushing the boundaries of knowledge. Get used to it. This process is immensely rewarding.
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The Social Network of Microbes. Our April Special Issue is now live! Find reviews and perspectives on the communication patterns and social lives of #microbes cell.com/cell-host-microbe/c…
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