Academic @UniofExeter. Computational psychiatry, medicine, brains, guitars, code, coffee, maths, cycling, beer, AI. Tired dad. Alum @cubriccardiff & @mrccbu
Exeter, England
Joined September 2014
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Alex 🇺🇦 retweeted
🧠 Our new paper Restoring Synaptic Balance in Schizophrenia: Insights From a Thalamo-Cortical Conductance-Based Model is now published in Schizophrenia Bulletin.
🚀 Join us at SiC25 – First Int’l Superintelligence Conf.
🗓 17–18 Sept 2025 | Exeter, UK
🎙 Keynotes: Bertie Müller, Ana Beduschi, Stuart Armstrong
Explore the future of #AI & #AGI 🌍
🔗 Register: lnkd.in/ezKJ3fTB
#Superintelligence
Alex 🇺🇦 retweeted
chance to do a phd with me on GABA alcohol alternatives un humans? findaphd.com/phds/project/fr…
Alex 🇺🇦 retweeted
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
go.nature.com/44hKo29
Testing an Active Inference agent in a 3D drone navigation task — it infers its own position and velocity from noisy observations, and selects actions by rolling out belief-based trajectories and minimizing expected free energy.
#ActiveInference #BayesianLearning #AI #AGI
🧠 You’ll tackle questions such as:
How do GABA-based drinks compare to alcohol in modulating neural and behavioural states?
Can we identify biomarkers of response or cognitive enhancement?
Sept 2025 start! Apply -
findaphd.com/phds/project/fr…
🚨 New preprint!
"Predictive Coding and Neurocomputational Psychiatry: A Mechanistic Framework for Understanding Mental Disorders"
read it: doi.org/10.31234/osf.io/wd23…
Alex 🇺🇦 retweeted
Premenstrual Dysphoric Disorder (PMDD) is not just “severe" Premenstrual Syndrome (PMS).
It affects 3–8% of women, leading to debilitating mood, cognitive, and physical symptoms due to altered neurosteroid sensitivity (Eisenlohr-Moul et al., 2017).
Here’s how neurosteroids impact PMDD & what every clinician needs to know. 🧵👇
Alex 🇺🇦 retweeted
Very proud of the team for showing that restoring GABA can mitigate behavioral & physiological deficits following frontotemporal lobar degeneration
A drug x MEG x PSP|FTD study #PSP #FTD
@wellcometrust @mrccbu @CambridgeBRC @CurePSP @PSPAssociation
alz-journals.onlinelibrary.w…
Alex 🇺🇦 retweeted
Clinical trials reveal that some antidepressants are over 100% more effective than placebo, while others barely outperform it.
The largest meta-analysis (Cipriani et al., 2018) compared 21 antidepressants in 116,477 patients, revealing striking differences in efficacy and tolerability.
Here’s what the study shows 🧵👇
Please do share and repost this PhD opportunity! It's a great opportunity to use computational methods to help elucidate the mechanisms of psychedelics... 🫶
🚨 Funded PhD opportunity! 🚨
"Computational Modelling of the Pharmacodynamics of Psychedelics"
Supervised by Dr Alexander Shaw and Prof Marc Goodfellow
Funded by EPSRC Doctoral Landscape Award
More info: lnkd.in/eXwv3ABm
Apply here: lnkd.in/es_9SSWK
🚨 Funded PhD opportunity! 🚨
"Computational Modelling of the Pharmacodynamics of Psychedelics"
Supervised by Dr Alexander Shaw and Prof Marc Goodfellow
Funded by EPSRC Doctoral Landscape Award
More info: lnkd.in/eXwv3ABm
Apply here: lnkd.in/es_9SSWK
New preprint !
"Restoring Synaptic Balance in Schizophrenia: Insights from a thalamo-cortical conductance-based model."
biorxiv.org/content/10.1101/…
with @liobanause and @magnetokrishio.
Alex 🇺🇦 retweeted
The brain has a surge in functional connectivity moments before death:
pnas.org/doi/abs/10.1073/pna…
Interesting article!
Averaging is a convenient fiction of neuroscience - Mark Humphries
thetransmitter.org/neural-co…
📢 PhD opportunity!
"Computing and translating mechanisms of neural network dysfunction associated with psychiatric risk"
A @GW4BioMedDTP project, supervised by Prof Matt Jones (Bris) and co-supervised Profs Jeremy Hall, Marianne van den Bree (Cardiff) & Me! (Exeter) ...
"...electrophysiology and computational generative modelling, patient-public involvement and engagement (PPIE) with children and young people, to define the neural network mechanisms contributing to psychiatric risk in people living with psychosis-associated genetic mutations"
Join our vibrant, innovative, supportive and collaborative team spanning Bristol, Exeter and Cardiff universities and encompassing genomic, cellular, circuit, cognitive and clinical analyses in patients and mice!
Apply: gw4biomed.ac.uk/computing-an…