We’ve spent decades treating lithium as a heavy duty psychiatric tool. New evidence suggests it’s actually a foundational brain nutrient and that Alzheimer’s may essentially be a localized lithium deficiency. By using the Orotate salt, we can bypass plaque-induced transport blocks and restore brain levels with 1mg. I’ve been supplementing low dose (1mg/day) lithium for years. More evidence now suggests it was the right decision. Here’s why lithium is potentially beneficial and how we arrived at this decision years ago. The study unequivocally demonstrated lithium deficiency in the brains of patients with cognitive impairment, providing mechanistic evidence of its role as a driver of disease onset and progression. It validated our choice of Lithium Orotate as the optimal form of lithium supplementation for preventing and slowing the progression of dementia. Lithium has long been a foundational ingredient in my protocol, utilized in a low-nutritional dose. This was based on our comprehensive analysis of various population studies supporting its safety and potential benefits for brain health and mental well-being. Establishing a direct mechanistic link: beyond its known effects on mood and well-being, the study forged a direct and mechanistic and progressive connection between lithium brain deficiency and cognitive impairment, including Alzheimer's disease. Optimal form of lithium: the study revealed that lithium orotate, the specific form of lithium salt I have been using for years, is superior in avoiding blockage by existing plaque, thereby achieving the highest bioavailability, greatest plaque reduction, and cognitive restoration in previously lithium-deficient mice with pre-existing cognitive impairment.