Founding Director @wyssinstitute, Judah Folkman Prof. of Vascular Biology @bostonchildrens & @harvardmed, Hansjörg Wyss Prof. of Bioinspired Engineering @hseas
Boston, MA
Joined May 2019
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Scientists have more to worry about than funding cuts. This essay describes the predatory nature of scientific journals and how they profit from the unpaid labor of scientists, who not only write papers but also pay high fees to get articles published.
bit.ly/4vE6OFb
Don Ingber retweeted
In a new review, Ryan Posey, @OzkanPhD, and @DonIngber of the @wyssinstitute examine the variety of organ-on-a-chip platforms that recreate human tissue interfaces, fluid flow, mechanical forces, and immune components.
The paper covers microfluidic technology, the use of organ-chips as preclinical tools, their applications in drug discovery, how they compare with other preclinical models, and what's needed to make them even better.
ALT Dark navy graphic with the following quote: "Integration of Organ Chips with high-throughput screening, functional genomic approaches, and artificial intelligence represents an emerging shift that enables rapid target identification, drug repurposing, and therapeutic discovery, while potentially reducing clinical failure rates." Two scientists working at a computer in a lab are shown in the upper half. Attributed to Ryan Posey, Alican Özkan, & Donald E. Ingber (2026) from Advanced Drug Delivery Reviews.
I am proud of Unravel Biosciences for being granted a Stage 1 Discovery Award from @longitude_prize, in partnership with @lajollalabs & @uni_ulm. Unravel will be applying their patient-in-a-loop discovery to treatment approach to identify targets for ALS treatment.
Learn more about the project and the other awardees: bit.ly/4tUQNe9
I wanted to share something I have been thinking about over the last week. I asked Gemini to craft an autobiographical essay describing its development to the point where it develops consciousness. Here is what it wrote:
bit.ly/4jjeY1k
Don Ingber retweeted
Immune tissue can shapeshift and fight intruders. How does it do this?
We show that stimulated B cell aggregates behave like multicellular liquid droplets whose physical state can be programmed by cytokines.
youtu.be/QAk2ayoVF0M
Pre-print: biorxiv.org/content/10.1101/…
Tune in to @60Minutes this Sunday from 7PM-8PM to learn more about how funding cuts and freezes are jeopardizing our research into potentially life-saving advances in medicine and how these actions could dismantle America’s lead in scientific innovation.
paramountpressexpress.com/cb…
Our work on the progression of Barrett’s esophagus into adenocarcinoma was published in Developmental Cell. Our findings suggest the need for treatment paradigms that go beyond targeting cancerous cells to incorporate stromal reprogramming. bit.ly/41djerh
Don Ingber retweeted
So excited to see this paper on the stromal changes driving Barrett’s Esophagus progression to Cancer. A Herculean effort effort integrating scRNASeq/CODEX/ECM proteomics.
Concerted changes in Epithelium and Stroma: a multi-scale, multi-omics... sciencedirect.com/science/ar…
Don Ingber retweeted
New paper out, amazing team @wyssinstitute - @DonIngber @mmsperry @anishvasan and many others
nature.com/articles/s43856-0…
"AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models"
15% of the drugs in the US’s development pipeline were made by companies headquartered in MA, which wouldn't be possible w/o government investments. Funding cuts leave this ecosystem at risk. Learn more in @BostonGlobe. bostonglobe.com/2025/06/08/o…
Is animal testing becoming obsolete? Not yet, but on yesterday’s episode of @OnPointRadio, I spoke with @MeghnaWBUR about it's used in drug development and how Organ Chips, organoids, and AI, might be used to enhance, and one day replace, these methods.
wbur.org/onpoint/2025/06/04/…
The Trump administration has launched a Blitzkrieg on science and academic freedom. As researchers, we must use our voices to advocate for science to protect patients, the economy, and truth itself. Read more in my op-ed in @TheScientistLLC.
the-scientist.com/from-the-f…
I’m so excited to announce the publication of this important paper in @BioMedCentral showing the value of Organ Chips for personalized medicine and clinical care in esophageal adenocarcinoma.
translational-medicine.biome…
Whether it’s due to concerns for animal welfare or a desire for more successful clinical trials, more people are recognizing the importance of finding more accurate alternatives to animal models, like Organ Chips. Read more from @business.
bloom.bg/43AXZ32
Boston’s high concentration of top universities, world-class hospitals, and venture capital firms makes it a perfect ecosystem for biotech innovation, but it's also left us vulnerable to the impact of political decisions. Read more from @TheEconomist.
economist.com/united-states/…
I spoke with Roland Pease on the @BBC's Science in Action about the timeline for scientific innovation, the valuable partnership between the U.S. Federal Government & universities, & the economic, intellectual, & medical impacts of recent funding freezes.
bbc.in/3GKetyc
Why should you care if scientific funding shrinks & academic institutions are under attack? University research drives innovation, job creation, & economic growth. Cuts threaten America's technological & economic leadership. Read more and share:
bizjournals.com/boston/news/…
When @ailsachang from @NPR interviewed me, she asked how I felt receiving the stop work orders. I was surprised and incredibly frustrated, but I remain proud to be a Harvard faculty member because we must speak truth to power. Listen here: npr.org/2025/04/17/nx-s1-536…
The @NIH is adopting an initiative to expand human-based models like Organ Chips. This tech, commercialized by @emulateinc, enables faster, better, & cheaper drug development. We'll see more successful clinical trials & better treatments.
nih.gov/news-events/news-rel…