Improving the dog genome knowledge as a model for human health
Helsinki, Finland
Joined September 2018
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📈 Whether studying tissue enrichment, disease genes, or SNPs, our Shiny app provides powerful visualizations (scatter plots, heatmaps) to aid in data exploration and discovery. #genetics #dataexploration
expression-atlas.doggenomean…
💡 With this Expression Atlas tool, researchers can easily access, analyze, and visualize canine promoter and gene expression, accelerating the study of genetics and diseases. #genomics #bioinformatics #dogresearch
expression-atlas.doggenomean…
Doga In use:
Smarter genome annotation with ANNEXA
🧬 Annotating the canine genome just got easier: ANNEXA + long-read RNA-seq = next-gen precision.
biorxiv.org/content/10.1101/…
Doga In use:
Canine transcriptional architecture mapped
📊 From promoters to enhancer clusters—Pol II regulation across the dog genome just got a whole lot clearer.biorxiv.org/content/10.1101/…
Doga In use:
🧠 Genetic mystery solved: The RSPO2 gene is associated with bilateral anterior amelia in Chihuahuas. Rare traits, now decoded.link.springer.com/epdf/10.10…
Doga In use: Check out this paper
Common variants in the CPT1A gene are now linked to cataracts in Northern dog breeds. A step forward in understanding inherited canine eye diseases.journals.plos.org/plosone/ar…
🔄 Switch easily between robust and comprehensive datasets: the comprehensive dataset includes all promoter regions, while the robust dataset focuses on those replicated in at least three samples. #dataanalysis #genomics
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🧠 The app lets you dive deep into behavior-associated SNPs, giving insight into how genetics impact dog behavior. Perfect for researchers studying canine genetics! #dogbehavior #genomics
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🌍 We’ve incorporated SNP cluster data from dog lineage and behavior studies! Visualize overlapping expression in heatmaps and explore SNPs related to lineage and behavior. #SNP #dogbehavior
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🧪 In the Disease-Associated Genes tab, search for genes and diseases from OMIA to visualize tissue expression linked to specific conditions, using scatter plots or heatmaps. #disease #genomics
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🔑 You can refine results by selecting a robust dataset with higher thresholds for expression levels and replicability, ensuring more reliable data for your research. #dataquality #genomics
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🧬 Our Tissue Enrichment Panels let users explore genes and promoters enriched in specific tissues. Just select a tissue or organ system to see a list of overexpressed genes. #genomics #bioinformatics
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🔬 We’ve developed a user-friendly Shiny appto provide intuitive access to DoGA promoters and gene expression data. Now exploring canine gene expression and tissue enrichment is easier than ever! #genomics #bioinformatics
expression-atlas.doggenomean…
📊 The Expression Panel in our app allows users to view promoter expression across various organ systems and tissues. Find genes and promoters by name or by searching specific regions. #genetics #doggenomics
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DoGA group meeting Jan 2025 in Helsinki.
Analysis presentation and discussion for future publications.
This year DoGA project achieved a milestone by our latest publication and addition to DoGA resources through DoGA expression atlas. We can’t wait to contribute to science in coming year. Happy new year from DoGA.
🌟 The DoGA Atlas is revolutionizing our understanding of gene regulation in dogs and wolves, setting the stage for cutting-edge research into genetic diseases, behavioral traits, and more. #CanineGenomics #GeneRegulation #ResearchBreakthrough
nature.com/articles/s41467-0…
🐕💡The DoGA resource is a huge step forward for both veterinary & human medicine! It's helping scientists decode the complex genetics of dogs & wolves for breakthroughs in disease treatment & prevention. #GenomicMedicine #VeterinaryResearch #DogHealth
nature.com/articles/s41467-0…
📚 The DoGA Atlas is now available! With interactive tools for gene expression and promoter data, it’ll accelerate studies on genetic diseases in both dogs & humans, making it a critical resource for scientists worldwide.
nature.com/articles/s41467-0…
🌍 Global collaboration leads to a transformative genomic resource! Over 5,000 canine & wolf samples, cutting-edge RNA sequencing, and a new era of cross-species research for genetic disorders. 🚀 #DoGAConsortium #GeneticResearch #VeterinaryScience
nature.com/articles/s41467-0…