@DimbergLab

We are studying the tumor microenvironment to understand cancer progression and response to therapy. Our goal is to find new ways to treat cancer.

 Rudbeck Laboratory, Uppsala
igp.uu.se/forskning/vaskularbiologi/anna-dimberg/
Joined May 2021
  • Tweets43
  • Following80
  • Followers156
2Media
Include

Only show posts containing:

Exclude

Hide posts containing:

Time range
-
Minimum likes
So exciting to see our PI Anna Dimbergโ€™s talk being featured as part of the most noteworthy highlights of #CIMT2024, the biggest cancer immunotherapy conference in Europe! ๐Ÿคฉ See the article here tandfonline.com/doi/full/10.โ€ฆ

CIMT 2024: Report on the 21st Annual Meeting of the Association for Cancer Immunotherapy

The 21st Association for Cancer Immunotherapy (CIMT) Annual Meeting took place from May 15th to May 17th in Mainz, Germany, and was attended by a total of 855 academic and clinical professionals ha...

tandfonline.com
1
158
Our preprint on tertiary lymphoid structures in human brain tumors is online! Joint work with colleagues from @FCI_health @goetheuni Edinger Institute. biorxiv.org/cgi/content/shorโ€ฆ
1
6
1
18
2,668
Want to sit back, relax and enjoy? Find also a short AI-generated audio summary of our paper here๐Ÿค– sciencecast.org/casts/8vkysoโ€ฆ
1
106
Extra curious?๐Ÿง Have a look at our paper to find out more about the interplay between ๐‘ช๐‘ซ4 ๐‘ป ๐’„๐’†๐’๐’๐’”, ๐’‡๐’Š๐’ƒ๐’“๐’๐’ƒ๐’๐’‚๐’”๐’•๐’”, ๐’Ž๐’š๐’†๐’๐’๐’Š๐’… ๐’„๐’†๐’๐’๐’” and ๐’„๐’๐’๐’๐’‚๐’ˆ๐’†๐’ ๐’“๐’†-๐’‚๐’“๐’“๐’‚๐’๐’ˆ๐’†๐’Ž๐’†๐’๐’• during the assembly of TLS in GBM!
1
123
We also dug deep into the early steps of TLS assembly, and found that ๐‚๐‚๐‘๐Ÿ•+๐ˆ๐‹๐Ÿ•๐‘+ ๐‚๐ƒ๐Ÿ’ ๐“ ๐œ๐ž๐ฅ๐ฅ๐ฌ are recruited to TLS nucleation sites, where they act as ๐ฅ๐ฒ๐ฆ๐ฉ๐ก๐จ๐ข๐ ๐ญ๐ข๐ฌ๐ฌ๐ฎ๐ž-๐ข๐ง๐๐ฎ๐œ๐ž๐ซ ๐œ๐ž๐ฅ๐ฅ๐ฌ and kick-start TLS development๐Ÿ.
1
44
Interestingly, a parallel study on TLS in GBM independently found similar results in a separate cohort of GBM patients! โœจ biorxiv.org/cgi/content/shorโ€ฆ #reproducibleresults #solidscience
1
1
49
We found that approximately 15% of GBM patients are TLS positive, and that ๐“๐‹๐’-๐ก๐š๐ซ๐›๐จ๐ซ๐ข๐ง๐  ๐ฉ๐š๐ญ๐ข๐ž๐ง๐ญ๐ฌ ๐๐ข๐ฌ๐ฉ๐ฅ๐š๐ฒ ๐š ๐ฉ๐ซ๐จ๐ฅ๐จ๐ง๐ ๐ž๐ ๐ฌ๐ฎ๐ซ๐ฏ๐ข๐ฏ๐š๐ฅ. This indicates that the presence of TLS is a positive prognostic marker for GBM patientsโœ….
1
50
See how we integrated human data from three types of ๐ฌ๐ฉ๐š๐ญ๐ข๐š๐ฅ ๐ญ๐ซ๐š๐ง๐ฌ๐œ๐ซ๐ข๐ฉ๐ญ๐จ๐ฆ๐ข๐œ๐ฌ with ๐ฅ๐จ๐ง๐ ๐ข๐ญ๐ฎ๐๐ข๐ง๐š๐ฅ ๐ฆ๐จ๐ฎ๐ฌ๐ž ๐ฌ๐ญ๐ฎ๐๐ข๐ž๐ฌ, to reconstruct the steps of ๐“๐‹๐’ ๐๐ž๐ฏ๐ž๐ฅ๐จ๐ฉ๐ฆ๐ž๐ง๐ญ in ๐’ˆ๐’๐’Š๐’๐’ƒ๐’๐’‚๐’”๐’•๐’๐’Ž๐’‚ ๐Ÿ”€๐Ÿง , a devastating tumor of the brain
1
56
While our paper is out for peer-review, have a sneak peak on bioRxiv ๐Ÿ‘€!
1
63
What if we knew more about the ๐’…๐’†๐’—๐’†๐’๐’๐’‘๐’Ž๐’†๐’๐’• ๐’๐’‡ ๐’•๐’†๐’“๐’•๐’Š๐’‚๐’“๐’š ๐’๐’š๐’Ž๐’‘๐’‰๐’๐’Š๐’… ๐’”๐’•๐’“๐’–๐’„๐’•๐’–๐’“๐’†๐’” (TLS) in ๐’„๐’‚๐’๐’„๐’†๐’“, to produce TLS-inducing therapies that can ๐’‰๐’†๐’๐’‘ ๐’‘๐’‚๐’•๐’Š๐’†๐’๐’•๐’”? ๐Ÿ’‰ Look no further than this thread! โญ๏ธ biorxiv.org/content/10.1101/โ€ฆ

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblas...

Tertiary lymphoid structures (TLS) are ectopic lymphoid aggregates associated with improved prognosis in numerous tumors. To date, their prognostic value in central nervous system cancers and the...

biorxiv.org
1
3
7
987
Vรฅrt projekt om hur blodkรคrlen pรฅverkar hur hjรคrntumรถrer vรคxer och svarar pรฅ terapi var ett av de 224 som fick anslag frรฅn @Cancerfonden! Tack alla som skรคnker gรฅvor till forskningen och gรถr detta mรถjligt! #tillsammansmotcancer #cancerfonden cancerfonden.se/nyhet/forsknโ€ฆ
2
1
15
717
๐Ÿ“ข ๐‘๐ž๐ฏ๐ข๐ž๐ฐ ๐š๐ฅ๐ž๐ซ๐ญ! How much do we really know about ๐ญ๐ž๐ซ๐ญ๐ข๐š๐ซ๐ฒ ๐ฅ๐ฒ๐ฆ๐ฉ๐ก๐จ๐ข๐ ๐ฌ๐ญ๐ซ๐ฎ๐œ๐ญ๐ฎ๐ซ๐ž๐ฌ in cancer?๐ŸงHere we review how studies in murine models have furthered our understanding of TLS biology๐Ÿญ. frontiersin.org/articles/10.โ€ฆ

Frontiers | Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer

Tertiary lymphoid structures (TLS) are lymph node-like aggregates that can form in association with chronic inflammation or cancer. Mature TLS are organized ...

frontiersin.org
1
1
8
873
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma dlvr.it/SqZ6Kv

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran etย al. show that targeting LIGHT expression to the brain vasculature using an adeno-associated viral vector prolongs survival in checkpoint blockade-resistant murine glioma. This...

cell.com
19
2
56
19,445
Read this week's #ResearchWatch: AAV-Mediated Gene Delivery of LIGHT Prolongs Survival in #Glioblastoma, summarizing the work of @mohanraj9706, @AleVaccaro93, @tiarnevdw, Magnus Essand, @DimbergLab et al. bit.ly/3q5eQLg @UU_University
6
1
16
2,792
DimbergLab retweeted
Mohan@mohanraj970626 May 2023
Our recent work on AAV-mediated #Immunotherapy for #Glioblastoma is highlighted by @CD_AACR.
Cancer Discovery@CD_AACR26 May 2023
Read this week's #ResearchWatch: AAV-Mediated Gene Delivery of LIGHT Prolongs Survival in #Glioblastoma, summarizing the work of @mohanraj9706, @AleVaccaro93, @tiarnevdw, Magnus Essand, @DimbergLab et al. bit.ly/3q5eQLg @UU_University
2
7
424
Online Now: Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma dlvr.it/Sp6vzN

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran etย al. show that targeting LIGHT expression to the brain vasculature using an adeno-associated viral vector prolongs survival in checkpoint blockade-resistant murine glioma. This...

cell.com
7
2
31
7,240
Congratulations to @mohanraj9706 , @AleVaccaro93 , @tiarnevdw and the rest of the team! It is finally out!!
DimbergLab@DimbergLab14 May 2023
Curious on how we modified blood vessels to boost immunity and treat brain cancer? ๐Ÿ’‰๐Ÿง  Our new publication is out now on @Cancer_Cell ! Big congrats to the first authors of this work, @mohanraj9706 , @AleVaccaro93 & @tiarnevdw , and to the whole team ๐Ÿฅณ cell.com/cancer-cell/fulltexโ€ฆ

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran etย al. show that targeting LIGHT expression to the brain vasculature using an adeno-associated viral vector prolongs survival in checkpoint blockade-resistant murine glioma. This...

cell.com
4
352
Curious on how we modified blood vessels to boost immunity and treat brain cancer? ๐Ÿ’‰๐Ÿง  Our new publication is out now on @Cancer_Cell ! Big congrats to the first authors of this work, @mohanraj9706 , @AleVaccaro93 & @tiarnevdw , and to the whole team ๐Ÿฅณ cell.com/cancer-cell/fulltexโ€ฆ

Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

Ramachandran etย al. show that targeting LIGHT expression to the brain vasculature using an adeno-associated viral vector prolongs survival in checkpoint blockade-resistant murine glioma. This...

cell.com
4
21
4
62
7,993
Load more