Flagship journal of @Intlsocdiff. Published by #Elsevier for 40+ years. All things relating to differentiation, development, stem cells and regeneration
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ALT Fig. 3. Image Analysis reveals proliferation differences based on differentiation stimuli. (A) Confluency seen within each well is graphed over the measurement period. (B) Representative images comparing macrophages at day 0 and day 18, with the differentiation agent concentration increasing down the image pairs.
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ALT Fig. 1. | Generation of scBAP1, sh1BAP1, sh2BAP1 stable cell lines and differentiation into neuronal progenitor cells (a) Post lentiviral transduction of human embryonic stem cells (hESCs) with scBAP1, sh1BAP1 and sh2BAP1 lentiviruses, was verified by enhanced green fluorescence protein (EGFP) at day 4, in absence of doxycycline (Dox-). DAPI (blue) was used to stain the nucleus. (Magnification: 20X)
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ALT Fig. 2. Characterization of bone fragments A. Representative H&E stained section of bone fragment showing abundant adipocytes in the bone marrow next to mineralized bone with osteocytes. Bar = 100 μm. B. Representative histological slides of BGLAP (Bone Gamma-Carboxyglutamate Protein) immunoreactivity in human bone samples. The black arrows point out the presence of lining osteoblasts expressing BGLAP. Bar = 50 μm.
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ALT "Type H vessels in osteogenesis, homeostasis, and related disorders," by Xiaoru Qin et al. Fig. 1. Vascular distributions in long bones. Type H vessels are located in the metaphysis and along the periosteal and endosteal surface, whereas type L vessels are located in the diaphysis's bone marrow cavity. Secretion of PDGFA, PDGFB, TGF-β1, TGF-β3, and FGF1 from type H ECs is significantly higher than that from type L ECs. More RUNX2+ and OSX+ osteoprogenitors and osteoblasts surround type H vessels.
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ALT Fig. 3. Histological section of the human placental bed from the late first trimester stained with pan-cytokeratin antibodies. Anchoring placental villi (V) with immunoreactive trophoblast lining are seen on the top. Numerous dissociated cytokeratin-positive extra-villous trophoblastic cells of ovoid or elongated shape are seen invading the underlying decidua (bottom). These cells arise from the solid trophoblastic columns that anchor the placental villi to the endometrium (arrows) through an epithelial-mesenchymal transition (EMT) process.
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ALT Call for Papers! Submit to the Splicing in Development and Disease Special Issue! Submission deadline: October 1, 2025. Guest editor: Natoya Peart, University of Waterloo, Canada. This special issue will address and highlight current understanding and gaps in knowledge about the role of splicing both constitutive and alternative in the development and how disruption of these processes leads to disease.
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ALT Fluorescence micrographs of testes stained with DAPI (blue), anti-Mettl3 (red) and anti-Vasa (green), as well as merged images”. A-A‴) control testis (UAS Mettl3 RNAi) (n = 19). B-B‴) nos-Gal4 knockdown testis (n = 18). C-C‴) bam-Gal4 knockdown testis (n = 14). Vasa stains spermatogonia and spermatocytes. Asterisk denotes hub. Scale bars indicate 25 μm.