@DidonnaLab
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The Didonna Lab aims at understanding the mechanistic connection between aberrant immune responses and neurodegenerative processes in chronic human diseases.
Greenville, NC
Joined November 2021
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Really excited to share our new work on the neuroprotective role of specific HLA alleles on Parkinson's disease that was published in Neurology N2 @GreenJournal @ECUBrodySOM
neurology.org/doi/10.1212/NX…
Didonna Lab retweeted
A new collaboration is driving the next phase of discovery. 🔎
A research team at #ECU’s Brody School of Medicine has been awarded a $250,000 grant to study how chronic brain inflammation contributes to Alzheimer’s and Parkinson’s diseases. 🔬
🔗: ecu.pulse.ly/7xxl5jewhl
ALT A group of four researchers wearing white lab coats stand and sit in a laboratory setting. Shelves with scientific equipment and supplies are visible in the background. The image includes the ECU logo in the upper right corner. Below, text reads "New grant fuels Alzheimer's and Parkinson's research" against a purple background with three yellow arrows pointing right.
We are deeply grateful to the Brody family for funding this collaborative opportunity and for bringing us together as a new research team @ECUBrodySOM @res
news.ecu.edu/2026/07/07/brod…
Didonna Lab retweeted
Check out the latest #NYASAnnals publication! Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin‐1 in B Cells nyaspubs.onlinelibrary.wiley…
Check out our new paper published today in @NYASciences -- We employed a multiomics pipeline to define ataxin-1 activity in B cells @ECUResearch
nyaspubs.onlinelibrary.wiley…
Didonna Lab retweeted
Tomorrow leaders and officials and our construction partners gather for a topping out ceremony for the Brody Center for Medical Education. It's a reminder that we're not just expanding, we're investing. In our best and brightest. In better health outcomes in #ENC.
Didonna Lab retweeted
Judge Jack Jenkins, youngest son of former ECU Chancellor Leo Jenkins, gave a Brody Auditorium lunchtime talk on his father’s leadership style. One tip that stood out — put in the work. Another, make the choice as leader you know is just and right in your heart.
Didonna Lab retweeted
Congrats biomedical sciences grad students on your _18_ first-author publications (28 total) this academic year, and particularly award winners Savanna Williams, Drew Theobald, Kathryn Lorbacher and (not pictured) Connor Cribb.
Nature research paper: Lineage and organ signals sequentially build organ intrinsic nervous systems
go.nature.com/4devih6
Didonna Lab retweeted
Shared Epitope-Positive HLA Alleles Protect Against Alpha-Synuclein Pathology in a Model of Parkinson Disease hubs.la/Q04f9SWY0
#NeuroTwitter #ParkinsonDisease
ALT Figure 1 HLA-DRB1*04:01 Expression Protects Against Synuclein Spreading In Vivo
Proud to see @EastCarolina recognized by the @cure345 Innovation Index as one of the top 303 U.S. institutions advancing biomedical innovation.
wewillcure.com/innovation-in…
Didonna Lab retweeted
#ECU researchers are driving what’s next. ⏩
More than 60 scholars, innovators and creators were recently honored for their contributions to research, creative activity and innovation.
Learn more ⤵️ bit.ly/4mAd3ao
I am truly grateful for receiving the Early Career Trendsetter Award. This achievement could have not been possible without the support of Brody, the Department of Anatomy & Cell Biology and all the dedicated people working in the lab.
Didonna Lab retweeted
Multiple molecular mimics in Epstein Barr Nuclear Antigen-1, and the pathogenesis of multiple sclerosis
pnas.org/doi/full/10.1073/pn…
Didonna Lab retweeted
Meet our 2026 Brody Brothers Endowment Research Grant recipients! These are primary investigators of deadly cancers, cellular metabolism, parasite-host dynamics and more. Thank you, Brody Family, for your _ongoing_ generous support of these researchers at @ECU.
Great teamwork for the traditional departmental door decoration contest that resulted in our first second place🎄
Didonna Lab retweeted
Some archaea—an ancient group of microorganisms—have an entirely novel genetic code, according to a new study in Science. Their genetic code reassigns a DNA “stop” signal to incorporate the rare amino acid pyrrolysine into their proteins.
The findings expand our understanding of how alternative genetic codes evolve and hint at new molecular tools for biotechnology applications. scim.ag/49xnYx3
Thrilled to see our paper published in @FEBSJournal — We used a novel conditional knockout line to dissect the function of ataxin-1 in the B cell compartment @ECUBrodySOM
febs.onlinelibrary.wiley.com…
Didonna Lab retweeted
BREAKING NEWS: @Roche have announced their BTK inhibitor, #fenebrutinib, has achieved successful trial results in both relapsing-remitting & primary progressive #MultipleSclerosis. #MS [1/2]
Read more: roche.com/investors/updates/…
A lab coordinator position is available at ECU Brody School of Medicine to manage the flow cytometry and cell imaging core facilities. If you have hands-on experience in these techniques and you are interested in the position apply here:
ecu.peopleadmin.com/postings…