Current Postdoc in the TAB-Lab at UoB. Former Oxford DPhil Student in the Booth group, Wolfson College, Bassoonist, Austrian, gamer, book-lover. he/him, 🏳️🌈
Oxford, England
Joined December 2011
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More of my postdoc work has now been published in @ChemEurope. This was a super fun project to work on, and with lots of diverse and challenging synthesis, characterisation, crystallography and DFT!
📰 The study of a homochiral perylene diimide dimer for sensing chiral anions is now out in @ChemEurope. Work led by Denis @DenisHartmann with contributions from previous MSci and MRes students Lucy and Jamie in the TAB-Lab @TabLabChem doi.org/10.1002/chem.2025012…
Dr Denis Hartmann retweeted
A Bis-Perylene Diimide Macrocycle Chiroptical Switch (Timothy A. Barendt and co-workers) @DenisHartmann @TabLabChem @UoBChemistry @ZwijCompChem #openaccess 🔓 onlinelibrary.wiley.com/doi/…
My first major piece of postdoc work in @TabLabChem is finally out in @angew_chem. 🎉
A new chiral macrocycle which shows three-way switching of its chiroptical properties out now @angew_chem. Work by @DenisHartmann in @TabLabChem & fantastic collaborators @SamuelPenty and Robert Pal at @DurhamChemistry and @ZwijCompChem at @UCLChemistry doi.org/10.1002/anie.2025011…
Dr Denis Hartmann retweeted
Starting off our second day with @DenisHartmann from @TABarendt talking about PDI macrocycles for molecular electronics and host-guest chemistry! #ECRMASC2024
My PhD work has made it into @SynCellEU 🥳
@DrMikeBooth and his team at @UCLChemistry have developed a method to turn gene expression on or off using multiple wavelengths of light.
A promising technique to study complex cellular processes and advance #syntheticcell #research and #technology!
More:
syntheticcell.eu/2023/05/22/…
Two of my PhD papers are now published back-to-back in @J_A_C_S! I really enjoyed working on those two projects, do go and give them a read 😁
Exciting 📢!
Our two @J_A_C_S articles have now been published back-to-back in the same issue 😍😍😍!
@DenisHartmann @Jack_Mazzotti @UCLChemistry @OxfordChemistry @OxfordSynthesis #DNA #ASO #synbio #cellfree #syntheiccell #photocage
And this is my last paper from my PhD published! 🎉
Another @J_A_C_S paper from the group!
We generated synthetic cells containing logic gates that can be *spatiotemporally patterned* with two orthogonal wavelengths of light!
Led by @DenisHartmann @JeffersonMSmith @Razia_C @OxfordChemistry @UCLChemistry bit.ly/3AyoAzF
Dr Denis Hartmann retweeted
We made *orthogonally* light-activated antisense oligonucleotides as precise switches for cell-free systems 🔦🧬
Published in @J_A_C_S 🤩!
Led by @Jack_Mazzotti @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #DNA bit.ly/3AlvQyO
Dr Denis Hartmann retweeted
We've topologically constrained antisense oligonucleotides into a handcuff structure, via photocages, to control gene knockdown!
Published in @ChemCommun, led by @DenisHartmann
@OxfordChemistry @OxfordSynthesis @UCLChemistry #supramolecular #ASO rsc.li/3zY0vC5
Dr Denis Hartmann retweeted
.@DrMikeBooth, @DenisHartmann and co. report photocaged antisense oligonucleotides to knockdown cell-free protein synthesis using light. @UCLChemistry @OxfordChemistry @OxfordSynthesis @UCLChemLight nature.com/articles/s42004-0…
Dr Denis Hartmann retweeted
We’ve developed light-activated antisense oligonucleotides by conjugating photocages to phosphorothioates 🤩🧬🔦!
Published in @CommsChem, led by @DenisHartmann @OxfordChemistry @OxfordSynthesis @UCLChemistry #ASO #DNA #light nature.com/articles/s42004-0…
Dr Denis Hartmann retweeted
We've got *2* EPSRC PhD opportunities to join our group in London to study the chemistry and application of nucleic acids, photocages, and polymers! 😍🧬🔦🌡️🧪
xitter.cf/DrMikeBooth/status/160…
📢 TWO new PhD positions 📢
Join my group in London to work on controllable nucleic acids for biology and medicine! 🧬🔦🌡️🔊🧫🧪😍
@UCLChemistry
Deadline 26th Jan 2023 / Start date Oct 2023
Details in below 🧵
One of my DPhil projects with @DrMikeBooth is now on chemRxiv! We developed light-activated antisense oligonucleotides by photocaging the backbone and could use that to control gene knockdown in cell-free expression! Have a look below!
@OxfordSynthesis @OxfordChemistry
We've developed light-activated antisense oligonucleotides by conjugating photocages onto phosphorothioates 😍🧬🔦!
We used these as cell-free expression OFF switches 🧪🛑⚡️!
Preprint from @DenisHartmann
@OxfordSynthesis @OxfordChemistry @UCLChemistry bit.ly/3P2uTSG
If you are curious what I spent a large part of my DPhil on so far, my project on blue light-activatable DNA is now available on ChemRXiv as a preprint! 🎉
@OxfordSynthesis @OxfordChemistry
We’ve developed blue light-activated DNA!
We used it to create the first dual light-activated cell-free logic gate 🤩🧬⚡️🧪
Preprint led by incredible student @DenisHartmann
@Razia_C @JeffersonMSmith @OxfordSynthesis @OxfordChemistry @UCLChemistry bit.ly/3b7EjwH
Dr Denis Hartmann retweeted
We’ve engineered light-activated communication between synthetic cells and living cells! 🧬⚡️🧫
Check out our preprint, led by my amazing student @JeffersonMSmith
@DenisHartmann @SynBioCDT @OxfordChemistry @UCLChemistry @SynCellEU @buildacell
biorxiv.org/content/10.1101/…
My poster is now up at the #Biochemistry2022 conference in Münster! Come have a look and chat to me (in 🇩🇪 or 🇬🇧) about blue-light controllable DNA, done under supervision of @DrMikeBooth as part of @OxfordSynthesis.
It is nice to have in person events again! 🎉
Preparing for a conference presentation with the smallest ironing board ever to iron the fabric poster 🎉
Dr Denis Hartmann retweeted
📢 4th Edition of @RoySocChem Nucleic Acids in Chemistry and Biology has now been released (Blackburn/Gait/Egli/@jwattsgroup) – The bible for scientists who work with nucleic acids
Furthermore, I wrote the revamped chapter on DNA and RNA Sequencing! 🥳
rsc.li/3OyMtNa
