& another surprise finding: SAPA co-opts previously uncharacterized intracellular pathogen response proteins to counteract protein aggregation. This could explain tissue-specificity as these are expressed in the digestive tract. (6/8)

SAPA sends aggregation-prone proteins to lysosomes, but without using macroautophagy. (5/8)

Explanation: SAPA (safeguard against protein aggregation) is triggered to stop the build-up of new aggregates. (4/8)

& #ProteinQC failure = less proteotoxicity so pharyngeal muscles are healthier. (3/8)

Starting conundrum: Failure of core #ProteinQC systems = less protein aggregation in the C. elegans pharyngeal muscles but more in the body-wall muscles. (2/8)

Thanks to @DormannL & @LemkeLab for last week's #GutenbergWorkshops! Great thought provoking talks tackling biomolecular condensates from so many different angles. Loved the long discussions.