@DelaneauGroup

Olivier Delaneau's research group - Department of Computational Biology, University of Lausanne, Switzerland.

odelaneau.github.io/lap-page/
Joined April 2020
  • Tweets66
  • Following54
  • Followers256
4Media
Hey network!👋 ❗️Just a heads up, we'll be scaling back our posts on this Twitter account. ✅️For the latest updates on our team (former) member's research, make sure to follow: ⏩️ @ODelaneau ⏩️ @simrubk ⏩️ @Diogo_M_Ribeiro ⏩️ @Rbn_Hfmstr
3
3
1,050
Delighted to share our paper "Assessing the impact of post‑mortem damage and contamination on imputation performance in ancient DNA" supervised by Barbara now out in @SciReports! @simrubk @ODelaneau @AnnaSapfo @dbc_unil @ISBSIB ➡️More details here: nature.com/articles/s41598-0…
7
1
12
1,964
We are happy to announce that our work on the impact of post-mortem damage and contamination on imputation performance in ancient DNA is now out on bioRxiv! biorxiv.org/content/10.1101/… @ODelaneau @simrubk @AnnaSapfo @dbc_unil @ISBSIB

Assessing the impact of post-mortem damage and contamination on imputation performance in ancient...

Low-coverage imputation is becoming ever more present in ancient DNA (aDNA) studies. Imputation pipelines commonly used for present-day genomes have been shown to yield accurate results when applied...

biorxiv.org
1
8
14
2,119
We found that: 1. Taking post-mortem damage (PMD) into account before imputation improves imputation accuracy of highly damaged genomes 2. Imputation is robust to moderate levels of PMD 3. Imputation performance breaks down for contamination>5%
80
Systems & Population Genetics Group | O. Delaneau retweeted
Robin Hofmeister@Rbn_Hfmstr8 Dec 2023
📢 New preprint alert! Refining SHAPEIT5 haplotypes using whole genome sequencing reads. 🧬On #UKbiobank, it confirms a fascinating trend-de novo mutations are more often paternally inherited. 👏 to Rick Wertenbroek and @ODelaneau for this smart work! biorxiv.org/cgi/content/shor…
14
1
36
3,956
Systems & Population Genetics Group | O. Delaneau retweeted
Robin Hofmeister@Rbn_Hfmstr4 Nov 2023
Hi #ASHG2023 ! 👋 Interested in the UK Biobank phased data I presented yesterday? Accessible to approved UKB researchers via #dnanexus. --> Meet @ODelaneau at poster 4261 today at 2:15 to delve into the application of these haplotypes for genotype imputation!
1
8
1
47
4,843
Systems & Population Genetics Group | O. Delaneau retweeted
Olivier Delaneau@ODelaneau22 Sep 2023
Happy to announce the release of 200k UK Biobank WGS phased with SHAPEIT5, together with cutting-edge imputation pipelines. Relevant links: - Processing: biobank.ndph.ox.ac.uk/showca… - Access: biobank.ndph.ox.ac.uk/showca… - Pipelines: srubinacci.gitbook.io/uk-bio… More details to come!
2
37
2
161
16,313
Systems & Population Genetics Group | O. Delaneau retweeted
Olivier Delaneau@ODelaneau26 Jul 2023
🎉 Thrilled to share a major career update! 🎉 I'm honored to join the Regeneron Genetics Center as Director in Statistical Genetics. Sad to bid farewell to Lausanne, but eager to contribute to the groundbreaking research done at the RGC! 🧬🖥️📊
10
8
2
186
22,753
Systems & Population Genetics Group | O. Delaneau retweeted
Diogo Ribeiro 🧬@Diogo_M_Ribeiro29 Jun 2023
Phasing of UK Biobank allowing compound heterozygous identification. Very happy to see this great collaborative work see the light 😉 thank you to the team @Rbn_Hfmstr @simrubk @ODelaneau @dbc_unil nature.com/articles/s41588-0…

Accurate rare variant phasing of whole-genome and whole-exome sequencing data in the UK Biobank

Nature Genetics - SHAPEIT5, a phasing method that accurately processes large sequencing datasets, was applied on the UK Biobank whole-genome and whole-exome sequencing data to generate reference...

nature.com
8
24
1,439
Check out the newest papers of our group released today in @NatureGenet ! Big thank to all contributing authors @simrubk @Diogo_M_Ribeiro @Rbn_Hfmstr Barbara Mota and @ODelaneau
Olivier Delaneau@ODelaneau29 Jun 2023
So excited to share our recent work! 🎉 Just released 2 innovative tools in Nature Genetics: nature.com/articles/s41588-0… nature.com/articles/s41588-0… Huge applause to my great team of brilliant researchers who made this possible! Stay tuned for deeper insights.
3
415
We are happy to announce that our study on imputation of ancient human genomes is now published in @NatureComms: nature.com/articles/s41467-0… Thank you to all co-authors! @simrubk @cegAmorim @yosoydcruz @siko76 @hannes @AnnaSapfo @ODelaneau @dbc_unil @ISBSIB
2
21
1
44
9,161
Systems & Population Genetics Group | O. Delaneau retweeted
Robin Hofmeister@Rbn_Hfmstr12 Jun 2023
Great talk at #eshg2023 by @simrubk on low coverage imputation from UK biobank WGS reference panel! Spoiler alert: The 200k UKB WGS reference panel will be available to UKB approved researchers in a few weeks, together with snp-array and low-cov imputation pipelines.
3
10
1,025
Systems & Population Genetics Group | O. Delaneau retweeted
Diogo Ribeiro 🧬@Diogo_M_Ribeiro26 May 2023
Enhancer-enhancer links are seldom researched. Our analysis of multimodal single cell data suggests that nearby enhancers are often co-active. Our paper from @chaymae_ziyani master thesis&internship is out now! nature.com/articles/s42003-0… @dbc_unil @ISBSIB @DelaneauGroup @MSCActions
5
2
15
1,591
Systems & Population Genetics Group | O. Delaneau retweeted
SIB@ISBSIB1 May 2023
Replying to @ISBSIB @cbg_ethz @ETH_en @TanjaStadler_CH
“A clever computational approach allowing to infer which genes an individual inherited from their parents without having any information on them." 🥁That’s what the committee said about this work, one of the #SIBRemarkableOutputs 2022👏 👉 Find out more: tinyurl.com/mwvvjpn
1
6
10
1,266
Systems & Population Genetics Group | O. Delaneau retweeted
Liza Darrous@LizaMGD13 Apr 2023
Our pre-print is out 🎉! Read below on how we performed informative clustering of BMI SNPs using PheWAS data of 400+ traits, this revealed several SNP groups that were enriched for distinct trait themes like body lean mass, job type and education, nutritional supplements..🧵👇1/4
medRxiv@medrxivpreprint12 Apr 2023
PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment medrxiv.org/cgi/content/shor… #medRxiv
1
15
1
45
12,833
A proposal to mitigate re-identification threats in anonymized reference panels: 1. Simulating offspring from reference samples 2. Using them as a reference panel for imputation! Checkout how well this works in our preprint: biorxiv.org/content/10.1101/…

A resampling-based approach to share reference panels

For many genome-wide association studies, imputing genotypes from a haplotype reference panel is a necessary step. Over the past 15 years, reference panels have become larger and more diverse,...

biorxiv.org
5
3
14
4,980
Excited to share our study characterizing cell-specificity in key immune cells by mapping regulatory regions with coordinated activity. This valuable insight can aid in interpreting GWAS findings related to complex human diseases. Thanks to all coauthors !
Communications Biology@CommsBio29 Mar 2023
Analysis of cis-regulatory domains derived from ChIP-seq peaks and methylation data in 3 key immune cells suggests cell-type specific regulatory mechanisms of immunity. @DianaAvalosM, @dermitzakis, @ODelaneau, @DelaneauGroup, @Diogo_M_Ribeiro, @AnnaRamisch nature.com/articles/s42003-0…
1
293
We are happy to share the version 2 of our low-coverage imputation software, GLIMPSE2! @dbc_unil @unil
Simone Rubinacci@simrubk30 Nov 2022
I am very excited that our new study presenting the GLIMPSE2 method is now available on @biorxivpreprint This is a major advance in low-coverage WGS imputation. We made our method scalable to reference panels containing hundreds of thousands of samples. biorxiv.org/content/10.1101/…

Imputation of low-coverage sequencing data from 150,119 UK Biobank genomes

Recent work highlights the advantages of low-coverage whole genome sequencing (lcWGS), followed by genotype imputation, as a cost-effective genotyping technology for statistical and population...

biorxiv.org
1
5
Systems & Population Genetics Group | O. Delaneau retweeted
Dept of Computational Biology, Uni Lausanne@dbc_unil17 Nov 2022
The @dbc_unil is deeply saddened by the sudden and tragic death of our colleague Alma Dal Co @Alma_DalCo. Our department lost an exceptional scientist, an inspiring teacher, a caring mentor, and above all a generous and cheerful colleague. In memoriam: unil.ch/dbc/home/menuinst/al…
2
50
1
137
Systems & Population Genetics Group | O. Delaneau retweeted
DMF UNIL@DMF_UNIL17 Nov 2022
We are shocked and saddened by the terrible news that our dear colleague Alma Dal Co suddenly passed away. She will dearly missed and we wish strength and courage to her family, friends, students and colleagues. Room GEN2024 is open to pay tribute and leave a message.
1
14
59
Load more