Professor of Neuroscience | Brain & Nutrition | Arousal & Appetite | 🇺🇦
ETH Zürich
Joined April 2022
- Tweets92
- Following159
- Followers399
- Likes122
We found a local GABA relay which converts orexin cell firing into Agrp cell inhibition,
thus anti-correlating arousal and hunger states in the brain: biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
In mice, orexin neurons multiplex the encoding of rapid body-movements with slow changes in blood glucose. The extent to which these neurons correlate with movement across behavioral and metabolic states surprised us! Now a Version of Record in @eLife. doi.org/10.7554/eLife.103738…
Do we feel less hungry when we dilate our eyes? Turns out when pupils dilate, hunger cells (Agrp) get inhibited. This underlies hunger suppression by novel sensations, and shapes food value perception in the brain. 👇
This effect is due to orexin/hypocretin neurons: when they disappear - as during narcolepsy - Agrp cells get overactive, especially during cataplectic attacks!
biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
Hunger-driving AgRP neurons are REM-active, and similarly re-activate during cataplexy. Hot off the press from the Burdakov lab!
biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint):
biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
Newest paper is on BioRxiv! We examine hypothalamic orexin (and MCH!) -producing neurons for their role in regulating decision policy complexity. Huge thanks to my supervisors @DeBurdakov and @RafaPolania
biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
Here's our latest issue: cell.com/neuron/current
The cover is for a Perspective piece by Lüthi & Nedergaard who discuss microarousals, and propose an inverted U-shaped relationship to reconcile their essential and disruptive roles: cell.com/neuron/fulltext/S08…
Cover by Nadia Alzoubi
Denis Burdakov retweeted
Lifestyle is a stronger predictor of aging and mortality than genetics.
A new Nature study of ~500,000 people found:
🎯 17% of mortality variation was linked to lifestyle (exposome).
🧬 <2% of was explained by genetics.
Here’s what you need to know 👇🧵 1/10
Thinking isn’t free, it costs 1000s of ATPs per bit. Complexity means more bits. Reduce complexity, or pay for it? Hypothalamic neurons have an answer: biorxiv.org/content/10.1101/…
Denis Burdakov retweeted
You just can't leave the dessert even though you're full? 🍰
Blame it on your POMC neurons!🧠
(details ➡️🧵)
Congratulations to Marielle Minère, @FenselauHenning and all other authors for their newest publication @ScienceMagazine ! 🎉
science.org/doi/10.1126/scie…
1/3
ALT Our brain has a sweet tooth. AI-generated image, Tool: Adobe Firefly.
Denis Burdakov retweeted
Our new paper is out in @CellReports
We show an inhibitory response of Orexin receptor type 2 (Ox2R) in a subset of MCH neurons.
doi.org/10.1016/j.celrep.202…
Denis Burdakov retweeted
"In a world of change, the learners shall inherit the earth, while the learned shall find themselves perfectly suited for a world that no longer exists."
- Eric Hoffer, philosopher and author
Denis Burdakov retweeted
@LabLuthi uncovers a dual role of #locus @coeruleus in #sleep -> 1) its strict gatekeeper role for the sleep cycle 2) the partial brain-body arousals it generates. Powerful minds behind all this: @alejandrosoriof @GFoustoukos @CardisRomain
nature.com/articles/s41593-0…
Denis Burdakov retweeted
This from a really nice review @NeuroCellPress (doi below) on Neurobehavioral meaning of pupil size. How far are we from measuring these things via phone cameras along with eye tracking to match content foraging, physiology & dwell times etc. ?
Seems doable & valuable.
Denis Burdakov retweeted
Huge congrats to @Karyna_mi for her paper published today in @ScienceMagazine! She found that the hippocampus is really important for a key strategy we use to make decisions called hidden state inference! 🧪 🧠science.org/doi/10.1126/scie… 1/7
Denis Burdakov retweeted
Yay. Finally it is out! If you are curious about how the brain controls the jaw in response to hunger you should read this: nature.com/articles/s41586-0…
