David Lab (@David_lab_UCD) header
David Lab (@David_lab_UCD) profile picture

David Lab

@David_lab_UCD

We are a chemical biology group at UC Davis studying DNA glycosylases involved in the base excision repair pathway (BER).

 Davis, CA
davidlab.ucdavis.edu
Joined March 2018
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Photo by David Lab (@David_lab_UCD)Photo by David Lab (@David_lab_UCD)Photo by David Lab (@David_lab_UCD)
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David Lab (@davidlab_ucdavis) • Instagram photo

David Lab (@davidlab_ucdavis) • Instagram photo

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Extremely proud of JJ: first Ph.D. exit seminar of the Heffern Lab. It is hard to say goodbye to the 1st generation of students, but it also reinforces the awesome job I have to raise scientists who will do more than I can alone. Congrats @JustinOSulliv17!! #asstproflife
Image from Marie Heffern (@marieheffern)
Image from Marie Heffern (@marieheffern)
Image from Marie Heffern (@marieheffern)
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Officially a future DoubleDoc! So many mentors got me to where I am today and the opportunity to choose @ZuckerSoM for the next 7 years. Special shout out to @David_lab_UCD showing me I can't live without research.
Image from Madeline Bright (@Maddy__Bright)
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David Lab retweeted
Dr Meming (@Dr_Meming) profile picture
Dr Meming@Dr_Meming1 Nov 2022
The thought inside my head vs when I say it aloud to my PI
Image from Dr Meming (@Dr_Meming)
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If you're interested in DNA polymerase mechanism, check out our latest perspective from @Freudlab and @WashingtonUiowa published in @COSB_CRSB. sciencedirect.com/science/ar… We highlight new insights into DNA polymerase mechanisms provided by time-lapse X-ray crystallography!
Image from Tyler Weaver (@tylermweaver1)
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David Lab retweeted
Dana Sowa (@danajsowa) profile picture
Dana Sowa@danajsowa17 Oct 2022
Happy to announce that our research focused on understanding the interaction between DNA repair proteins Ku and LigD has been published in nucleic acids research! Thank you to @monicamwarner for her contributions to the project and @structureSara for her amazing mentorship! 🤩
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Don’t miss out on your chance to present a poster in person at the 2022 Inorganic Chemistry Symposium! For more information on posters and to register go to: chemistry.ucdavis.edu/semina…
Image from UC Davis Department of Chemistry (@UCDChem)
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Just in! First selfie from our 2022 #NobelPrize laureate in chemistry @CarolynBertozzi. Congratulations!
Image from The Nobel Prize (@NobelPrize)
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I earned a badge from Schrodinger! A huge thank you to the @ACSCOMP + @Schrodinger partnership for offering free registration for the online course: Introduction to Molecular Modeling in Drug Discovery! It was a fantastic learning experience! api.badgr.io/public/assertio…
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BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
Image from The Nobel Prize (@NobelPrize)
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In our recent preprint, we tested the requirements for the ssDNA-binding protein RPA in different stages of eukaryotic DNA replication… biorxiv.org/content/10.1101/…
Distinct RPA functions promote eukaryotic DNA replication initiation and elongation

Distinct RPA functions promote eukaryotic DNA replication initiation and elongation

Single-stranded DNA binding proteins (SSBs) are essential for DNA replication across all domains of life, but vary significantly in their structure and subunit composition. The eukaryotic SSB,...

biorxiv.org
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I have an NIH/VA-funded postdoc position available in my lab to study UV DNA damage responses in non-replicating cells and in human skin from young vs. geriatric individuals. Please share!
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Happy to announce that we won Best Poster at the 1st annual @QBI_UCSF Bay Area Chemical Biology Symposium. So proud to represent @FangFangShen1 , @lmkdassama, Liting, @lisha_ou , @JeandeleElliot, and I's work on targeted delivery and degradation of "undruggable" proteins in SCD!
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Excited to share our new preprint reporting an HPLC-MS based approach to quantify cisplatin DNA intrastrand crosslinks in cells. Fantastic effort by postdoc Arnie Groehler to develop a new tool to investigate the basis of resistance to cisplatin therapy biorxiv.org/content/10.1101/…
Image from Orlando D. Schärer (@orlandoscharer)
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my favorite thing about getting my PhD at UCD was quite literally the friends i made along the way. @JoePerryman1 and i were in the same cohort. 6 yrs later, we were married by his PhD advisor @Velazquez_Lab with 4 UCD grad students standing beside me. grad school isn’t all bad!
Image from Nina Perryman (@NinaHoward92)
Image from Nina Perryman (@NinaHoward92)
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Extremely excited to kickstart my lab @TU_Muenchen with Emmy Noether support from @dfg_public. I’m very grateful to @JKeithJoung, my friends in Boston, and to A. Moretti, K.L. Laugwitz & C. Kupatt in Munich. More details & website coming soon. #CRISPR 🫀
Image from Julian Grünewald (@grunewaju)
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Our work from the @Freudlab describing how the DNA repair protein APE1 binds and processes AP sites in the nucleosome is now out in @NatureComms! @NIGMS @KUcancercenter nature.com/articles/s41467-0…
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It is official! We are now ACS Pride! Check out the change in handle (@ACSPride_prof) and give us a follow.
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The UC Davis Chemistry Department is looking to hire a new inorganic tenure track Assistant Professor! For more information on this position use the following link. recruit.ucdavis.edu/JPF05148…
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Our latest paper on pioneer transcription factor p53 is out. In this paper, we reported the cryo-EM structures of p53 bound to the nucleosome, in which nucleosomal DNAs are partially released from the octameric histone core. academic.oup.com/pnasnexus/a…
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