Prague, Czech Republic
Joined September 2010
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Jestli je omezeni Starlinku UA jen do voleb nebo trvale se ukaze, ale to ze je Trump ve slabe a zavisle pozici vuci Rusku, Iranu nebo Cine je pruser, ktery nema US administrativa dopustit. Von Braun psal, ze Elon ma vladnout Marsu, ale v leccem ma vetsi moc nez US prezident..
David Siska retweeted
Russia’s Yandex data centres were hit, and shared charts show bot traffic from its network plunging. 📉
If Kremlin troll farms were affected too, perhaps real people will finally get more of a voice on social media. 🇺🇦💪
Par lidi v kuklach u zakladny rekne, ze se chysta dron utok a vsechny letadla bez vystrelu zmizi z Evropy
Sef rozvedky dostane v ruske bance teple misto, banka “nahodou” zkrachuje, on ruci a je v dluzich a rusove mu radi za sluzbicku pomuzou..
Tomu rikam efektivita
Ukrajina pristi rok vyrobi a pouzije 10mil dronu. US vytvori platformu pro zlevneni a zrychleni vyroby zbrani zapadnich spojencu (#wish). NATO neprebira knowhow z UA armady.. youtube.com/watch?v=NB-E6yRq…
David Siska retweeted
I agree with Dario that we need to pace the frontier. This has been a primary topic of discussions we've had at OpenAI in recent weeks.
Committing to having independent evaluators with employee-like access is a great idea, and we will do the same. We'll have more to share soon.
We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so.
Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training.
You can read the full post here: darioamodei.com/post/we-must…
David Siska retweeted
running a gamble with humanity to fill a void of meaning
(this rings extremely true to me)
The reason that is rarely articulated, for obvious reasons, but which is nonetheless true: for many this fills a void of meaning. They get be one of the decisive few at the decisive moment in the history of life. Very similar to the emotions that motivated many revolutionaries of days past. All of the sudden the small things one does—the books one reads, one’s office set up, one’s bedtime routine—take on an awful cosmic significance. The whole history of carbon life is culminating with *me* — and what I do, and the few elect here with me, matters, and matters immensely. We are the agents of history, the only people in the world doing something that truly, deeply matters. And if we all die? Well we were all going to die anyway. But this is the one way we might *not* all die. And I get to be a part of it.
David Siska retweeted
"Nejsme připraveni odevzdat svou svobodu tomuto zasranému teroristovi Putinovi"
....vše, co jsem chtěl vědět o tom, co Witkoff a Kushner dovezli z Moskvy do Kyjeva, je v této větě.
Dva dny manevry NATO kolem Kaliningradu a dnes sef CIA v Rusku 🤔 To vsechno pred UK povolenim a licencovanim Stormshadow UA.. naposledy ho neposlechli, aby neutocili na Ukrajinu
David Siska retweeted
Russian propaganda doesn't want you to know about Soviet-Nazi collaboration 1939-1941.
The Hitler–Stalin Pact: The Deal That Cleared the Way for War
Eighty-seven years ago today, Nazi Germany and the Soviet Union signed an agreement that cleared the way for the Second World War. Yet the Hitler–Stalin Pact still occupies surprisingly little space in Europe’s collective memory. It remains a stark symbol of the destructive power of totalitarian rule and offers an important lesson for the present: despite their ideological differences, totalitarian regimes tend to co-operate against free societies and sovereign states.
On August 23rd 1939 Joachim von Ribbentrop, Hitler’s foreign minister, and Vyacheslav Molotov, his Soviet counterpart, signed a non-aggression pact in Moscow, under Stalin’s watchful eye. Its bland public language concealed a secret protocol dividing much of central and eastern Europe into German and Soviet spheres of influence. For Poland, it amounted to a fourth partition.
The pact cleared the way for Hitler’s invasion of Poland from the west on September 1st. On September 17th the Soviet Union invaded from the east. This was no mere neutrality agreement, as Russian propaganda still likes to claim, but the political framework for the destruction and occupation of a sovereign state.
German–Soviet co-operation continued until Hitler turned on Stalin on June 22nd 1941. Soviet grain, oil and metals helped Germany withstand the British blockade and sustain its early military campaigns; deliveries continued until shortly before the invasion of the Soviet Union. In return, Germany supplied machinery, industrial technology and military equipment.
The relationship extended beyond diplomacy and trade. German and Soviet security officials met to discuss prisoner exchanges, population transfers and the suppression of Polish resistance. On September 22nd 1939 German and Soviet commanders appeared together at a military ceremony in Brest-Litovsk. The footage accompanying this post offers a stark image of the partnership: the Wehrmacht and the Red Army standing side by side after the defeat of Poland.
The published pact was barely 300 words long. For ten years, the two powers promised to refrain from “any act of violence, any aggressive action, and any attack on each other”. The real substance lay in its secret protocol. Poland was divided between them; Finland, the Baltic states and Bessarabia were assigned to their respective spheres of influence.
The arrangement was revised after Poland’s defeat in the German–Soviet Boundary and Friendship Treaty of September 28th 1939. Germany gained additional territory in central Poland, while Lithuania was transferred to the Soviet sphere. The Soviet occupation and eventual annexation of the Baltic states followed, as did the attack on Finland and the seizure of Bessarabia.
A policy of sweeping repression was quickly imposed in the occupied territories. Deportations, arbitrary arrests and mass executions were among its instruments. The Nazi German occupiers committed grave crimes against the Polish population, particularly Jews and members of the country’s social elites. In the spring of 1940 the Soviet NKVD murdered thousands of Polish officers and members of those elites; Katyn became the best-known site of this crime. These atrocities laid bare the brutality of both occupying powers.
The partnership also required some abrupt adjustments to historical truth. “Who controls the past controls the future,” George Orwell later wrote. A Bavarian schoolteacher reportedly captured the absurdity of the new German line: “Now one has to be rather careful at school. Suddenly you read something aloud from Hitler’s book Mein Kampf, and then you end up in Dachau for disparaging the present government.”
After Germany invaded the Soviet Union, Moscow performed its own reversal. References to the preceding co-operation disappeared from Soviet books, newspapers and encyclopaedias. The Soviet authorities denied the existence of the secret protocol until 1989.
The pact still occupies a curiously modest place in western Europe’s historical memory, particularly in Germany. German remembrance rightly centres on responsibility for National Socialism and the Holocaust. But this has sometimes fostered the suspicion that greater attention to Soviet crimes and German–Soviet co-operation might dilute that responsibility. It does not. The experience of central and eastern Europe cannot be understood without both.
In 2009 the European Parliament designated August 23rd as the European Day of Remembrance for Victims of Stalinism and Nazism. This was an important step. But the pact and its consequences still need to become more firmly embedded in Europe’s collective memory.
Roger Moorhouse, a British historian, found an apt name for the arrangement: "The Devils’ Alliance" is the title of his important book.
Neuvěřitelný, že Musk má teď na obranu Ukrajiny větší vliv než US prezident. Jedna soukromá osoba vs celý západní svět (1mld+ lidí) ft.com/content/ff536e6e-dc56…
David Siska retweeted
TLDR: I’ve started a small fund from my Base44 money that’s focused on cancer research and breakthrough therapies.
I’ve invested in 7 incredible companies in the past 4 months and plan to do more as my liquidity allows. Listing my investment thesis below
I welcome anyone like me who has been blessed financially to join me and find ways to finally manage or even end this disease.
Longer -
I honestly believe cancer is humanity's worst enemy.
~40% will be diagnosed with it, and out of which a ~third won’t make it. And numbers are currently not getting dramatically better.
For many it might sound like a statistic
But for some of us who have been there ourselves or had to go through it with a person we love, it’s one of the worst things you can imagine.
I had to go through it with my mom - who passed away 4 months ago and whom I miss and think about every single day since.
This field needs a dramatic push.
The current wave of technology and AI is doing a lot of good in the world,
But cancer therapy is one of those things that are not moving nearly fast enough.
And there’s no good reason for that - AI is creating so much opportunity right now.
Here's my thesis on how things will play out:
For drug development, the bottleneck will shift to
1. Manufacturing
2. Real world testing
"In silico" is going to accelerate incredibly fast. AI is identifying new target proteins and designing new molecules, drastically shortening timelines.
AI will create an abundance / inflation of ideas. It will help design molecules faster than anything historically possible.
This is already happening.
Play with Claude Science or Codex and you'll be surprised at how far you can get with just a few prompts.
We need a better way to *manufacture and test* the 1000s of ideas coming from AI models spitting out potential drug candidates
1. Manufacturing: i.e. how fast can we synthesize a potential drug
Not too far into the future, companies with manufacturing excellence will win over companies with the smartest scientists.
Being able to synthesize a drug candidate fast - together with efficient methods to test efficacy (more on that below), basically means you get more shots at a target hence more chances at succeeding.
This is the same exact lesson the software industry learned about the importance of fast iterations.
Companies like Starget Pharma are leveraging AI heavily to iterate on drug candidates + figured out in-house manufacturing in a way that lets them iterate on drugs almost as fast as if they were a software company iterating on features.
2. Real world testing: i.e. how fast can we get a call on a drug's efficacy.
We need better real-world indicators for drug efficacy than mouse / animal models.
The success rate of animal models -> human clinical trials is less than 8%.
Breaking down this bottleneck will change the entire industry.
Developing an oncology drug and taking it through all clinical trials usually cost >> $ 100m
Thus taking the wrong bet is devastating (but still, happens a lot).
Giving drug development companies the ability to better understand the efficacy and mechanisms of their drugs will change a lot. Esp in the age of abundant drug candidates.
Furthermore - and once those methods proved efficient - Joining forces with regulators to shorten (or even skip) some clinical trials altogether will cut years from the process and save many lives by bringing new drugs to market faster.
CuResponse is pioneering functional testing - taking real cancer biopsies and showing drug efficacy with very high precision. Can be used for precision oncology as well as testing new drugs.
Cellint is providing a fully automated cell-culture R&D platform for companies and researchers.
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I’d love to see a future where there are “cloud services” for drug development companies.
A company should eventually be able to submit a drug candidate programmatically and receive:
1. The synthesized drug.
2. Testing across cells, tissues, organoids, and tumoroids.
3. Structured results showing what worked, what failed, and why.
4. A recommended next iteration derived from the biological reactions.
I’ve invested in all of the above companies and am searching for additional companies to bring this “cloud services for drug dev” vision to life.
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Alongside it, I am also investing in direct therapeutic moonshots.
I invested in Baccine, which is developing a bacteria-based cancer immunotherapy platform and deserves an entire separate post.
I’m also a proud LP in Even One Ventures - @sytses ’s fund to fight cancer. Sid and Jacob Stern are an inspiration to me as I’m making my first steps in the field, and I bet their companies will make a massive impact.
And 3 other incredible companies focused on how therapies are delivered - where I’ll elaborate in future posts.
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I’m still obviously spending most of my time on Base44. Which is a plus for the companies - as we’re able to support them with tools, software, AI agents, etc.
I’m looking for people to join me - invest side by side or help one of the companies.
I don’t have a name for the fund yet, nor an email or a website
I will get to it this weekend and will post it in the comments.
Protidronova obrana nema silver bullet a s AI embedded to bude orech 🤷♂️
You have to see this! South Korea shows how to defend against a drone swarm
During drills on the country's west coast, 50 drones simulated a low-altitude swarm attack.
Eight Vulcan air defense guns shot down 44 drones with concentrated barrage fire. The remaining six were taken out using a portable laser system and shotguns.
It's how South Korea is preparing for one of modern warfare's biggest threats: coordinated drone swarm attacks.