Co-Director of @ICNARC. Honorary Professor, Department of Medical Statistics, @LSHTM. All views my own.

Joined January 2012
David Harrison retweeted
To measure gastric residual volume or not? Today at #WFPICCS2026, @lyvonnetume shared @GASTRIC_PICU Trial results and important evidence to inform care. Thank you to the children, families, participating sites and research partners who made this possible. #PaediatricCriticalCare
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David Harrison retweeted
🧵 Presented at #WFPICCS26: Among critically ill children with hypotension receiving invasive ventilation and vasoactive drugs, a permissive #BloodPressure target of the fifth percentile for age did not significantly change the composite outcome of mortality and duration of invasive ventilation at 30 days vs usual care. The permissive target was associated with lower exposure to vasoactive drugs without a signal for harm. ja.ma/4rBWwVH #WFPICCS26 @WFPICCS
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David Harrison retweeted
Congratulations to our trustee Professor Manu Shankar-Hari on his NIHR Senior Investigator appointment, and to our Scientific Advisor Professor Kathy Rowan on her reappointment - a fantastic achievement for both.
We’ve announced the latest cohort of NIHR Senior Investigators, reflecting the breadth of modern research leadership. For the first time, the cohort includes two senior research leaders from Northern Ireland, alongside increased representation from post-1992 universities. Senior Investigators are among NIHR’s most influential researchers, driving innovation, mentoring future leaders, and shaping policy and practice. Learn more about this year's cohort.👉nihr.ac.uk/news/new-nihr-sen…
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David Harrison retweeted
The impact of skin tone on performance of pulse oximeters used by NHS England COVID Oximetry scheme: measurement and diagnostic accuracy study bit.ly/4pAN5U9 With linked commentary bit.ly/4qqeGbR
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David Harrison retweeted
Pulse oximeters provided by NHS COVID Oximetry scheme yielded higher oxygen saturation measurements for patients with darker skin tones compared with those with lighter skin tones, which could translate into clinically important differences, finds study bmj.com/content/392/bmj-2025…
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David Harrison retweeted
We are pleased to announce that the results of the #EXAKTstudy are published today in @bmj_latest.
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🎄 On the fourth day of Christmas CCR brings to thee 🎁 Four thousand seven hundred children 🎅 No routine gastric residuals measured routinely 🎶 And a partridge in a pear tree #CCR26 criticalcarereviews.com/meet…
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David Harrison retweeted
Our clinical audits support quality improvement in in-hospital cardiac arrest @NCAA_ICNARC and critical care @CMP_ICNARC & INICUA. We’re building a log of QI projects to inspire others. Got a project to share? We’d love to feature it 👉 [email protected]
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We're looking for some fantastic critical care clinicians (of any discipline) to join our Trustee board. Please share with your relevant networks. @ICS_updates @FICMNews @UKCCRGroup @BACCNUK
We are currently recruiting for the following positions: New Clinical Trustees to join our Board of Management, full details and how to apply can be found via lnkd.in/eEQEQPsQ Principal Statistician, full details and how to apply can be found via lnkd.in/ei
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David Harrison retweeted
The UK-ROX trial has officially hit its recruitment target of 16,500 patients after 3 incredible years. 🌟 A huge THANK YOU to all participating sites for your dedication & hard work—this wouldn’t have been possible without you! 🏆👏 @ICNARC
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Are you involved in the delivery of health services or health services research? I'd be grateful if you took 10-15 min to complete this survey. You'll contribute to strategies for overcoming barriers to implementation decisions monash.az1.qualtrics.com/jfe…
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David Harrison retweeted
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Although maybe out of scope, the brief section in the @covidinquiryuk Module 1 report on research omits that a big success of UK (and global) research in the pandemic — @remap_cap — was funded as pandemic preparedness research as part of the €32m EU @PREPARE_EUROPE project
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David Harrison retweeted
Know any former ICU patients or family members who would like to be involved in improving ICU at a national level? Please put them in touch with us! #PPIE #ICU @ICUsteps @ICS_updates @LifeLines_ICU @PatientsAssoc @HDR_UK
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I feel the need to wade in and dampen some of the enthusiasm for the win ratio at #CCR24. But first, in the interest of balance, when *do* I think it is a good approach… 1/n
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With these, you can very easily construct a single hierarchical ordinal outcome… assign deaths 30, survivors who receive KRT 29 and everyone else their ICU LOS 1-28. This massively opens up the options for analysis. 4/n
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I’ve actually oversimplified here- we need 57 levels to replicate the win ratio hierarchy: death=57, LOS+28 for survivors that received KRT, LOS for survivors that did not receive KRT
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But you could also use a GLM approach, such as a proportional odds model - this would have been my primary analysis of choice for DEFENDER. This allows you to include covariates, such as the stratification variables from the randomisation, which is always a good idea. 6/n
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It gives you an odds ratio as an effect estimate, which is generally better understood. And, even when the proportional odds assumption is violated, it gives you results that are consistent with the non-parametric approach. 7/7
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