@davidasinclair

Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan

 Harvard
lifespan.com
Joined March 2012
  • Tweets11.2K
  • Following1.2K
  • Followers666K
2.7KMedia
Breaking lifespan.com/blogs/magazine/…

Encouraging Preliminary First Results From Phase I Trial of ER-100

The epigenome, the system that helps control which genes are turned on and off in our cells, can become disrupted during aging and disease. Epigenetic restoration is based on the idea that some of...

lifespan.com
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It’s a privilege to get cancer. Not everyone gets to get cancer
Lancesico 🇱🇨
@BornakangOct 24
Cameron Diaz said, "There's no such thing as anti-aging. We're all aging, period... It's a privilege to get older, not everybody gets to get older."
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David Sinclair retweeted
Lifespan
@JoinLifespanOct 24
Peptides are everywhere, but “peptide therapy” can mean anything from an FDA-approved medicine to an untested vial labeled “For Research Use Only.” What do we actually know about the compounds people are injecting? lifespan.com/blogs/magazine/…
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Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner biorxiv.org/content/10.1101/…

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

Nicotinamide adenine dinucleotide (NAD) is essential for many enzymatic reactions, including those involved in energy metabolism, DNA repair and the activity of sirtuins, a family of defensive...

biorxiv.org
Jesse Morse, M.D.
@DrJesseMorseOct 23
Replying to @DrJesseMorse
For NAD+ users: NMN and NR didn't extend lifespan here, and the NIH's ITP found the same for NR. Small arms, so not the last word. But there's still no good evidence that NAD+ precursors extend mammalian lifespan. An important note to make.
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True
Marcos Arrut
@MarcosArrutOct 22
Rejuvenation without the loss of cellular identity. That is the fundamental problem of cellular reprogramming. Once solved, anti-aging biology will usher in the brightest era in human history. That's all.
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Woohoo
Life Biosciences@lifebiosciencesOct 22
Proud to be named one of @Fortune’s Best Workplaces in BioPharma 2026! This recognition reflects the people behind our mission and the collaborative culture driving our work to advance epigenetic restoration to reverse diseases of aging. View the list here:bit.ly/4hKrfgd
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Yup
Chubby♨️
@kimmonismusOct 22
Next step: Longevity and Rejuvenation. We are almost there. Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA. The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.
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Never thought to squeeze a cell
Prof Steve Horvath
@prof_horvathOct 22
Squeezing a fibroblast nucleus for a moment opens chromatin at mappable loci. Yang Song and Song Li at UCLA aimed CRISPRa guides at exactly those spots. Fibroblast to neuron conversion went from under 3% to about 40%, with no virus. In aged mouse fibroblasts, the same mechanically enhanced Oct4 activation lowered DNA methylation age on the mouse skin clock, close to the level of cells from young animals. But global methylation also drops. so how much of this is rejuvenation rather than dilution is the open question. Title: Mechano-epigenetic enhancement of CRISPR activation of target genes fo… sciencedirect.com/science/ar…
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David Sinclair retweeted
Lifespan
@JoinLifespanOct 22
Bowhead whales can live for >200 years - longer than any other known mammal on earth! 🐳 Enjoy more science cartoons in Lifespan Magazine: lifespan.com/magazine
🤖 Made with AI
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Big congratulations to Dr. Christoph Gorgulla @StJude, a Lifespan Foundation Laureate, with a check for $100K to study AI-mediated drug design using quantum Thank you to subscribers of LS Magazine, who help support the Lifespan Foundation & research like Christoph's 🙏
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So true - the Information theory of aging in 2008: NAD+ ➡️ sirtuins ➡️ histone modification ➡️ epigenetic stability ➡️ cellular identity ➡️ slower aging cell.com/cell/fulltext/S0092…
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontologyOct 21
NAD boosting and epigenetic restoration are two levers aimed at the same aging biology. David Sinclair (Harvard Medical School) at #ARDD2026. Photos: agingpharma.org/photos2026
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hms.harvard.edu/news/potenti…

Potentially Universal Mechanism of Aging Discovered

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hms.harvard.edu
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It’s confusing. Some studies examine sildenafil (Viagra), others tadalafil (Cialis). So many new studies are indicating surprisingly positive effects on various organs & even immune cells fighting cancer. How about a new Lifespan episode called “What’s not to love?”
WayneTheWebGuy
@WayneTheWebGuyOct 21
Replying to @davidasinclair
On your latest Rogan podcast, you mentioned both Tadalafil and Sildenafil but it was confusing which one you were referring to at times. It might be worth a followup post to clarify your position on both. Thank you from a long-time follower and fan!
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What great comments! Thanks all 🙏
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There is no convincing evidence that low dose Cialis associated with altered lens proteins or causes cataracts. There are potential side-effects to discuss with a physician, like a potentially slightly higher occurrence of a “stroke in the eye” (NAION), as with GLP-1RAs
Lina@Livingdadream22Oct 21
Replying to @davidasinclair
Hubby started C 5 months ago now cataract? Any link to this being common ?
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David Sinclair retweeted
Lifespan
@JoinLifespanOct 21
People are living longer than ever. But could the average lifespan really jump by another 10 years? Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
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Today it was great meeting with the team to chart the future
Michael Ringel, JD PhD@M_S_RingelOct 20
The story of this technology is amazing. Happy to be able to share it, and big kudos to @davidasinclair lab in originating it!
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NEW PAPER: In rats, the NAD booster NMN effectively alleviates polycystic ovary disease, a common cause of infertility, by increasing SIRT2 activity, suggesting NMN as a possible therapeutic
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more replies
Highlights from authors: 1. NMN effectively ameliorates metabolic and endocrine disorders in PCOS 2. NMN activates granulosa cell glycolysis via SIRT2-mediated LDHA deacetylation 3. LDHA then converts pyruvate to lactate 3. K119 is a critical functional acetylation site of LDHA. 4. Targeting the SIRT2/LDHA-K119 axis improves follicular development in PCOS
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The paper: sciencedirect.com/science/ar…
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