SLiM propagandists Migrating to @slim-team.bsky.social
London, England
Joined June 2014
- Tweets91
- Following11
- Followers551
- Likes8
Short Linear Motif team retweeted
Great collaboration with the @DaveyLab on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore!
A proteome-wide dependency map of protein interaction motifs biorxiv.org/content/10.1101/…
Short Linear Motif team retweeted
Cool work from @duxin_lab on Pol Kappa. Happy that my lab together with @DaveyLab could contribute with base editing screening in cells.
Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis biorxiv.org/content/10.1101/…
Short Linear Motif team retweeted
Minimum Information About Disorder Experiments (MIADE) guidelines provide community recommendations on the minimum information that should be reported with experiments that structurally characterize intrinsically disordered proteins or regions.
@DaveyLab
nature.com/articles/s41592-0…
Short Linear Motif team retweeted
Time to get the disordered protein field a bit more ordered! We propose guidelines on how to describe IDP experiments to better serve experimental researchers, computational biologists, and database/method developers. This was a fun community wide effort led by @DaveyLab
A third of all known proteins are either completely or partially unstructured.
EMBL scientists contributed to MIADE, a new set of guidelines that will help researchers share data on such proteins in a more useful way & enable machine learning analyses.
embl.org/news/science/bringi…
Short Linear Motif team retweeted
Join us in July for our meeting on the assembly & organization of regulatory signaling systems! Speakers include: @m_madan_babu, @DaveyLab, @gingraslab1 & @Ivarssonlab.
Submit an abstract by 5/31: asbmb.org/meetings-events/mo….
Thank you to our sponsor @DartmouthBCB! #ASBMBMotifs
ALT Save the date, July 11–14, 2023, for ASBMB's conference, "Motifs, modules, networks: Assembly and organization of regulatory signaling systems." Font is black against a white background.
Short Linear Motif team retweeted
A new phosphomimetic proteomic peptide phage library is used to screen for phospho-modulated interactions between #shortlinearmotifs & protein domains ➡️ embopress.org/doi/full/10.15… @Ivarssonlab @UU_University @DaveyLab @ICR_London #phosphorylation
Short Linear Motif team retweeted
Also in the May issue, read Opinions on:
targeting #SLiM-binding pockets for #antivirals (@IvarssonLab @NilssonLabCph @mcinerney_gerry @DaveyLab) and #phaseseparation in receptor signaling (@LadburyLab).
cell.com/trends/biochemical-…
Short Linear Motif team retweeted
Our community effort to study AlphaFold2 applications is now published. Beyond the science what I want to highlight was that this was possible because scientists were sharing early results on twitter and this was the result of putting that together. nature.com/articles/s41594-0…
Short Linear Motif team retweeted
Hi all, Hazem here. I've just started my secondment in @Ivarssonlab. We were discussing what the most important large-scale ubiquitination datasets. What’s your favourite proteomic, CRISPR screens and protein half-life data paper on E3s? All suggestions r appreciated!
#E3ligases
Short Linear Motif team retweeted
Motif-based interactions go high-throughput: @Ivarssonlab @DaveyLab develop an optimized phage peptidome that tiles all disordered regions of the human #proteome --> bit.ly/3AoJYqo #ProteinProteinInteractions
Short Linear Motif team retweeted
#AlphaFold as disorder prediction? Turns out, it's remarkably good. @DaveyLab and I tested two scores derived from AlphaFold structures by @DeepMind and @emblebi and it seems to outperform our current method. Data and details at tinyurl.com/AFforIDP and below. It's a 🧵!
Short Linear Motif team retweeted
Great new paper from Peter Pryciak with an elegant in vivo assay for motif analysis. Changing CDK motif affinity alters cell cycle timing of Sic1 degradation--very cool! Stay tuned for our Dispatch about the paper. @DaveyLab
Are consensuses hindering protein motif discovery? Our collaboration with the Pryciak & Loog Labs using deep mutational scanning of Cyclin docking motifs shows SLiM binding determinants are much more complex than commonly used consensus representations. cell.com/current-biology/ful…
Short Linear Motif team retweeted
We have a Marie Curie ITN funded #PhD position available. Looking for fun and creative students enthusiastic about studying signalling mechanisms to join the lab. #ubiquitin #Ubimotif
More details here: lifesci.dundee.ac.uk/vacanci… Please spread the word!
Short Linear Motif team retweeted
Research highlight #Cellsignaling: The motif behind #PP2A – B56 specificity (£) go.nature.com/2aMyOQH @MolecularCell