@Daugherty_Lab
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Watching the constant battle between hosts and pathogens in the lab and in my kids.
San Diego, CA
Joined February 2018
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Matt Daugherty retweeted
I am delighted to share the latest preprint from our lab, which was work that was conceived and led by @JTenthorey during her postdoc and during the first few months of her independent lab at UCSF.
biorxiv.org/content/10.1101/…
TL;DR: Indels matter. A lot.
1/
Great work from @lizfay20 and a team of undergrads she has assembled! So much interesting data in this paper (check out the paper and Liz’s summary). Definitely the first of many great papers from Liz on host diversity in immune responses!
Our latest preprint from @Daugherty_Lab is live on bioRxiv! We explore the evolution and function of RIP kinases across diverse vertebrates and identify differential conservation of RIPK1-5 and several key associated proteins. 1/ biorxiv.org/content/10.1101/…
Another great collaboration with @DengkeMa lab on the role of horizontal gene transfer (HGT) in providing novel functions to nematodes! Congrats to all, especially co-first authors Taruna Pandey and @ChinmayK98 !
Interdomain horizontal gene transfer: @dengkema, @Daugherty_Lab and coworkers find that key rml-3 gene conferring nematode exoskeleton resilience against environmental toxins appears to stem from the bacterial kingdom
embopress.org/doi/full/10.15…
Matt Daugherty retweeted
New work from our @ASAP_Research team: nature.com/articles/s41594-0…. Parkinson’s disease-linked LRRK2’s closest relative, LRRK1 is tightly regulated via different mechanisms than LRRK2. Great collaboration with @aleschziner, @Daugherty_Lab, and Knapp labs
So great to reunite with all of these wonderful friends and scientists to celebrate such a fantastic mentor. Congratulations @HarmitMalik on all you've accomplished in the last 20 years!
A privilege to watch trainees thrive in science & life. Huge thanks to 70+ who traveled from as far away as France for 20 yr reunion hosted by Aida de la Cruz, @psmitchej & @Daugherty_Lab.
My heart is full (& our bellies).
I wish all mentors can feel what I'm feeling right now.
Very proud of Sofia Delgado-Rodriguez's first first-author paper (with a lot of help from Andy Ryan)! And it made the cover! This is part of a fantastic special issue on ADP-ribosylation organized by @LeungLab and @FehrLab.
🎉 #PathogensMDPI, Vol. 12, Issue 5
🔖 Cover Story: Recurrent Loss of #Macrodomain Activity in Host #Immunity and #Viral Proteins by Sofia E. Delgado-Rodriguez, Andrew P. Ryan, and Matthew D. Daugherty @Daugherty_Lab @UCSanDiego
👉 mdpi.com/2076-0817/12/5
#ADPribosylation
But many macrodomains hadn’t been tested for enzymatic activity. Not surprisingly, many host and viral macrodomains are enzymatically active. What was surprising was that enzymatic activity has been lost several independent times in mammals as well as in alphaviruses.
Matt Daugherty retweeted
Also, check out my episode of “Let’s Meet the Virologists” to learn a little about me and my career. Thanks to @lbthackray for having me on!
Meet Dustin Glasner @drglasner who studies the interface between #viruses and #innate_immunity. Check out his #ASV2023 Talk W8-1: Recognition of non-self viral mRNAs by the IFIT2 and IFIT3 heterodimer #LoveVirology lmtv.podbean.com/e/lmtv-epis…
Matt Daugherty retweeted
With #ASV2023 only a few days away, this seems like a good time to resurface here on Twitter. Come hear all about my research with @Daugherty_Lab on Saturday in the Innate Immune workshop. Can’t wait to connect with my fellow virologists for the first time since 2016!
Very proud of @underthelenns for her first first-author manuscript! She wrote a fantastic review on the evolution and mechanisms of 'tripwire' sensing of viral infection by the CARD8 and NLRP1 inflammasomes. Many more great things to come from Lennice!
Excited to see that our review on tripwire effector-triggered immune sensing of viral proteases by CARD8 & NLRP1 is out! My first, first-author pub, and I was lucky to write it with @Daugherty_Lab and the support of fellow Daugherty Lab members.
sciencedirect.com/science/ar…
Matt Daugherty retweeted
Innate immune #CARD8 mechanism for sensing #coronavirus & #picornavirus infection by detecting activity of #virus-encoded proteases; genetic variants in mammalian hosts affect which viruses can be sensed @BriBerryTea @psmitchej @Daugherty_Lab #PLOSBiology plos.io/43S8JZk
Matt Daugherty retweeted
Biologists led by the @Daugherty_Lab have identified a previously unknown way that our immune system detects viruses. The immune protein CARD8 acts as a trip wire to detect a range of viruses, including the virus that causes COVID. today.ucsd.edu/story/researc… @PLOSBiology
Our paper on CARD8-mediated sensing of infection by SARS-CoV-2 (and other coronaviruses and picornaviruses) is now out in
@PLOSBiology
! journals.plos.org/plosbiolog……Huge congratulations to all involved! More info and thanks to our many collaborators are in the thread below:
New preprint out showing a cool new host- and virus-specific way that the immune system has evolved to sense coronavirus infection!
biorxiv.org/content/10.1101/…
Congrats to everyone involved, especially force-of-nature first author @BriBerryTea! 1/
Huge thanks to @BriBerryTea, @nandangokhale, @JKulsuptrakul, @lizfay20, @underthelens, @russellevance, @hydelab, @RamLabUW, and @psmitchej and all of the other authors not on Twitter.
Matt Daugherty retweeted
Got a chance to share our story on a podcast with @Daugherty_Lab! Also my first time speaking on a podcast 🥳
Check it out here - open.spotify.com/episode/1NL…
Chinmay Kalluraya and Matthew Daugherty explain how vertebrates acquired a gene critical for vision from bacteria in the latest Science Sessions podcast: ow.ly/an8a50OurhW
Matt Daugherty retweeted
Chinmay Kalluraya and Matthew Daugherty explain how vertebrates acquired a gene critical for vision from bacteria in the latest Science Sessions podcast: ow.ly/an8a50OurhW
Matt Daugherty retweeted
Bacterial genetic origin in vertebrate eye evolution: @atnjoly recommends this @ChinmayK98 @Daugherty_Lab study in @PNASNews that finds interphotoreceptor retinoid-binding protein was inherited by horizontal gene transfer into the vertebrate genome
facultyopinions.com/article/…
Matt Daugherty retweeted
A new study shows that IRBP, a protein necessary for vision in vertebrates, was acquired from bacteria over 500 million years ago. @Daugherty_Lab @ChinmayK98
@PNASNews article: ow.ly/B69l50NMksY
@ScienceMagazine digest: ow.ly/9JJI50NMksZ
