@DashLab1

Chemical Biology; Unravelling the realm of DNA & RNA #PI Jyotirmayee Dash #OrganicSynthesis #TargetingNucleicAcids & #SupramolecularChemistry of Nucleic Acids

 IACS, Kolkata, India
iacs.res.in/faculty-profile.html?id=98#
Joined December 2019
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Researchers at @iacskolkata have designed artificial membrane transporters that mimic natural membrane channels using self-assembling bis-guanosine derivatives. The stimuli-responsive, size selective nanostructures efficiently deliver drugs and dyes into cancer cells, offering new possibilities in precision therapies. Read more: doi.org/10.1016/j.xcrp.2024.… @DrJitendraSingh @rajesh_gokhale @India_Alliance @CSIR_NIScPR @SMCC_NIScPR
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Prof. Jyotirmayee Dash has joined the Editorial Board of Bioorganic & Medicinal Chemistry Letters, a highly regarded journal that publishes research in bioorganic and medicinal chemistry. sciencedirect.com/journal/bi…
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Self-assembled lipophilic guanosine derivatives modulate membrane transport across lipid bilayers: Cell Reports Physical Science cell.com/cell-reports-physic…

Self-assembled lipophilic guanosine derivatives modulate membrane transport across lipid bilayers

Kumar et al. report artificial transporters constructed from synthetic scaffolds derived from the natural nucleoside guanosine. Self-assembled columnar aggregates embed within lipid membranes,...

cell.com
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Check out our new publication in @NatureComms 🥳 In collaboration with the lab of Dr. Jyotirmayee Dash "A non-B DNA binding peptidomimetic channel alters cellular function" Full text: nature.com/articles/s41467-0…

A non-B DNA binding peptidomimetic channel alters cellular functions

Nature Communications - Here, authors demonstrate that a peptidomimetic forms membrane channels and transports ions. It induces time-dependent cancer cell death via stabilization of G-quadruplexes...

nature.com
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Sharing a roadmap: authors.elsevier.com/a/1j%7E…
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Synthesis of Phenanthrenes and 1-Hydroxyphenanthrenes via Aromatization-Assisted Ring-Closing Metathesis: toward Polynuclear Aromatic Hydrocarbons | The Journal of Organic Chemistry pubs.acs.org/doi/full/10.102…

Synthesis of Phenanthrenes and 1‑Hydroxyphenanthrenes via Aromatization-Assisted Ring-Closing...

Abstract. This study presents an efficient synthetic strategy for phenanthrenes and 1-hydroxyphenanthrenes through aromatization-assisted ring-closing meta

pubs.acs.org
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Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization - now published in Chemical Communications pubs.rsc.org/en/content/arti…

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization†

The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulti

pubs.rsc.org
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Happy to Share our recent article: A non-B DNA binding peptidomimetic channel alters cellular functions Nature Communications volume 15, Article number: 5275 (2024); rdcu.be/dLtEL
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Efficient Synthesis of Cyclohepta[b]indoles and Cyclohepta[b]indole‐Indoline Conjugates via RCM, Hydrogenation, and Acid‐Catalyzed Ring Expansion: A Biomimetic Approach - Parui - Chemistry – A European Journal - Wiley Online Library chemistry-europe.onlinelibra…

Efficient Synthesis of Cyclohepta[b]indoles and Cyclohepta[b]indole‐Indoline Conjugates via RCM,...

Efficient catalytic assembly for cyclohepta[b]indoles is achieved through sequential transformations: ring-closing metathesis, catalytic hydrogenation, and acid-catalyzed ring expansion. Ring...

chemistry-europe.onlinelibrary.wiley.com
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Combating Multidrug-Resistance in S. pneumoniae: A G-quadruplex Binding Inhibitor of Efflux Pump and its Bio-Orthogonal Assembly academic.oup.com/narmolmed/a…

Combating multidrug-resistance in S. pneumoniae: a G-quadruplex binding inhibitor of efflux pump...

Abstract. Antibiotic resistance poses a significant global health threat, necessitating innovative strategies to combat multidrug-resistant bacterial infec

academic.oup.com
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Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization - now published in Chemical Communications pubs.rsc.org/en/content/arti…

Guanosine-based hydrogel as a supramolecular scaffold for template-assisted macrocyclization†

The G-quartet-like supramolecular assembly present in guanosine hydrogel templates macrocyclization between bis-azide and bis-alkyne fragments. The resulti

pubs.rsc.org
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Total Synthesis of Racemic Benzomalvin E, a Quinazolinone Isolated from Pencilium sp. FN070315 and Exploration to the Direct Synthesis of (E)-Benzomalvin B | The Journal of Organic Chemistry pubs.acs.org/doi/full/10.102…

Total Synthesis of Racemic Benzomalvin E, a Quinazolinone Isolated from Pencilium sp. FN070315 and...

Abstract. We present the first total synthesis of (±) benzomalvin E, featuring a quinazolino moiety with a 6–6–6–7-fused tetracyclic skeleton containing th

pubs.acs.org
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Selective Recognition of c-KIT 1 G-Quadruplex by Structural Tuning of Heteroaromatic Scaffolds and Side Chains | ACS Medicinal Chemistry Letters pubs.acs.org/doi/10.1021/acs…

Selective Recognition of c‑KIT 1 G‑Quadruplex by Structural Tuning of Heteroaromatic Scaffolds and...

Abstract. In this study, carbazole (MC) and dibenzofuran (MD) derivatives were synthesized to examine their effect on the biomolecular recognition of G-qua

pubs.acs.org
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Potassium tert-Butoxide-Mediated Cascade Synthesis of Rutaecarpine Alkaloid Analogues: Access to Molecular Complexity on Multigram Scales | The Journal of Organic Chemistry pubs.acs.org/doi/10.1021/acs…

Potassium tert-Butoxide-Mediated Cascade Synthesis of Rutaecarpine Alkaloid Analogues: Access to...

Abstract. In this study, we present a novel and cost-effective approach for synthesizing biologically significant analogues of rutaecarpine alkaloid throug

pubs.acs.org
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Pleased to share this #JOrgChem article by @DashLab1 and @SOUMYABASAK81 on KOtBu-mediated cascade synthesis of rutaecarpine alkaloid analogs from 2-aminobenzonitriles, showcasing broad substrate scope. Please have a look: pubs.acs.org/doi/10.1021/acs…
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Our heartiest congratulations to all the winners of the 'OPPI Scientist Award 2023' at the #OPPIAnnualSummit. You’re all an exemplary example of excellence & perseverance, lending your expertise to the further development of India’s healthcare ecosystem. #BharatKeLiye
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Nucleoside-Derived Metallohydrogel Induces Cell Death in Leishmania Parasites | ACS Infectious Diseases pubs.acs.org/doi/10.1021/acs…

Nucleoside-Derived Metallohydrogel Induces Cell Death in Leishmania Parasites

Abstract. Self-assembled hydrogels by virtue of their unique 3D network and tunability have extensively been explored for bio-medical applications like tis

pubs.acs.org
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Nucleic acids as templates and catalysts in chemical reactions: target-guided dynamic combinatorial chemistry and in situ click chemistry and DNA/RNA induced enantioselective reactions - now published in Chemical Society Reviews pubs.rsc.org/en/content/arti…

Nucleic acids as templates and catalysts in chemical reactions: target-guided dynamic combinatorial...

Nucleic acids play crucial roles in transferring cellular information and gene regulations. DNA and RNA molecules have been associated with multiple human

pubs.rsc.org
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