Daniel Yu (@Daniel_S_Yu) header
Daniel Yu (@Daniel_S_Yu) profile picture

Daniel Yu

@Daniel_S_Yu

Postdoc in the Banfield lab at JIC | PhD in the Williams lab at ANU | Structural biology | Plant-microbe interactions | 🇦🇺

 Norwich, England
Joined September 2021
  • Tweets38
  • Following206
  • Followers224
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Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)Photo by Daniel Yu (@Daniel_S_Yu)
Daniel Yu retweeted
Josh (@Joshwbennett) profile picture
Josh@JoshwbennettAug 7
I am really excited to share the first chapter of my PhD, where we characterise a genetically linked NLR/MLKL pair underpinning the Rwt3 resistance locus in wheat! With yet another KFP involved in monocot immunity 🌾biorxiv.org/content/10.64898…
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Super excited to share our latest work! We cloned Rwt3.6.8, a novel wheat NLR/MLKL resistance gene pair that recognizes three distinct AVR effectors (PWT3, PWT6, and PWT8) from the blast fungus Pyricularia oryzae. biorxiv.org/content/10.64898… #Blast #Wheat #KFP #phytopathogenetics
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Daniel Yu retweeted
Kobe Lab (@Kobe_Lab_) profile picture
Kobe Lab@Kobe_Lab_Feb 6
Check out our recent preprint on the structure of a non C-JID TNL resistosome from flax. We are very proud of the persistence of Natsumi who got this long running project over the line and a congratulations to all involved. Check it out... doi.org/10.64898/2026.02.03.…
Image from Kobe Lab (@Kobe_Lab_)
Image from Kobe Lab (@Kobe_Lab_)
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Excited to share our new paper available on bioRxiv! We cloned Rmo2 and Rwt7, genes for resistance to the blast fungus, from barley and wheat. Both genes are orthologs encoding TKPs with an integrated N-terminal HMA domain. doi.org/10.64898/2025.12.15.… #Blast #TKPs #Barley #Wheat
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Evolution of HMA-integrated tandem kinases accompanied by expansion of target pathogens biorxiv.org/content/10.64898… #biorxiv_plants
Evolution of HMA-integrated tandem kinases accompanied by expansion of target pathogens

Evolution of HMA-integrated tandem kinases accompanied by expansion of target pathogens

Tandem kinase proteins (TKPs) are an emerging family of plant intracellular immune receptors that offer potential for developing novel disease resistance. We cloned Rmo2 and Rwt7 , genes for resist...

biorxiv.org
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Engineering plant tandem kinase immune receptors expands effector recognition profiles biorxiv.org/content/10.64898… #biorxiv_plants
Engineering plant tandem kinase immune receptors expands effector recognition profiles

Engineering plant tandem kinase immune receptors expands effector recognition profiles

Plant intracellular immune receptors are widely deployed in breeding to protect crops from disease. In addition to nucleotide-binding leucine-rich repeat receptors (NLRs), tandem kinase proteins...

biorxiv.org
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Excited to share our #plantimmunity preprint on engineering cereal tandem kinase proteins (TKPs): biorxiv.org/content/10.64898… A short thread below.
Engineering plant tandem kinase immune receptors expands effector recognition profiles

Engineering plant tandem kinase immune receptors expands effector recognition profiles

Plant intracellular immune receptors are widely deployed in breeding to protect crops from disease. In addition to nucleotide-binding leucine-rich repeat receptors (NLRs), tandem kinase proteins...

biorxiv.org
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more replies
(4/5) The effector binding interfaces on the HMA domains of Rmo2 and Rwt7 are spatially distinct. We engineered both TKP-HMAs to gain binding to non-cognate effectors in vitro and in plant cells.
Image from Daniel Yu (@Daniel_S_Yu)
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(5/5) Incorporating the engineered HMAs domains into TKP receptors, we demonstrate the engineered receptors have expanded recognition profiles in cereal protoplast assays.
Image from Daniel Yu (@Daniel_S_Yu)
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Excited to share our review on structure-based engineering of NLRs in plant immunity. We also have some cool plant immunity engineering stories coming out this month so watch this space! #plantimmunity #nlr sciencedirect.com/science/ar…
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Finally, our preprint on revisiting the evolution and function of NIP2 paralogs in the Rhynchosporium is out. Thanks to @McdonaldMeganc @petersolomon99 and everyone who was involved in this project :) biorxiv.org/content/10.1101/…
Revisiting the evolution and function of NIP2 parologs in the Rhynchosporium spp. complex

Revisiting the evolution and function of NIP2 parologs in the Rhynchosporium spp. complex

The fungus Rhynchosporium commune, the causal agent of barley scald disease, contains a paralogous effector gene family called Necrosis-Inducing Protein 2 ( NIP2 ) and NIP2-like protein ( NLP )....

biorxiv.org
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😀 Thanks to @rey_darma_ for his hard work on his PhD project, here he explores the diversity of the NIP2 paralog family and challenges a long-standing result that this effector induces necrosis, an important example of a negative result worthy of publishing
Reynaldi D. (@rey_darma_) profile pictureReynaldi D.@rey_darma_18 Oct 2024
Finally, our preprint on revisiting the evolution and function of NIP2 paralogs in the Rhynchosporium is out. Thanks to @McdonaldMeganc @petersolomon99 and everyone who was involved in this project :) biorxiv.org/content/10.1101/…
Revisiting the evolution and function of NIP2 parologs in the Rhynchosporium spp. complex

Revisiting the evolution and function of NIP2 parologs in the Rhynchosporium spp. complex

The fungus Rhynchosporium commune, the causal agent of barley scald disease, contains a paralogous effector gene family called Necrosis-Inducing Protein 2 ( NIP2 ) and NIP2-like protein ( NLP )....

biorxiv.org
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Pls RT! We have a funded #PhD position for UK students available @DurBiol. If you're interested in protein design and the idea of making molecular machines get in touch and join us at the new Centre for Programmable Biological Matter @durham_uni! shorturl.at/TF0Gg
Image from Adam Bentham (@AdamRBentham)
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AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition 📖ow.ly/BAHl50REa2U by Outram et al. @WileyPlantSci #PlantScience
The crystal structure of AvrSr27-1 reveals a novel, metal-bound effector fold.

ALT The crystal structure of AvrSr27-1 reveals a novel, metal-bound effector fold.

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Please spread the word! This year’s Stromlo Plant Pathology Meeting will be held in beautiful Queenstown, New Zealand, on Aug 31-Sep 01 (queenstownresearchweek.org/p…)! Queenstown at that time of year is simply amazing, with lots to do: queenstownnz.co.nz/ 1/2
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Today marks the end of my time at ANU. I would like to thank @williams_simonj for being such an amazing mentor and supervisor. Will miss all the Williams lab crew! On to the next journey with @mjbanfield and @pd_christine at the @JohnInnesCentre
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@Carl_McCombe @nurentasneem @ZhaoLi07431129 @MeganOutram91 @ErinHHill
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