@Dr_LPJ

Neurologist and researcher @Cambridge_Uni, working on neuroinflammation and multiple sclerosis

 Cambridge, England
lpjlab.org/
Joined April 2010
  • Tweets7.3K
  • Following835
  • Followers808
2.1KMedia
Finally, it's out!!! Please read, enjoy, and share our latest publication on @Nature! One step closer to understanding progression in #MultipleSclerosis! Thanks to all the collaborators and to the @Pluchinolab nature.com/articles/s41586-0…

Mitochondrial complex I activity in microglia sustains neuroinflammation

Nature - Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease...

nature.com
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Nature Metabolism
@NatMetabolism21 Nov 2025
The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease go.nature.com/489uho7

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease

Nature Metabolism - This Review highlights how metabolic interactions between microglia and neurons shape brain health, and how their disruption in ageing and disease contributes to cognitive decline.

nature.com
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RESTORE@RESTORE_MS5 Sep 2025
🎧 RESTORE’s Dr. Luca Peruzzotti Jametti (@DR_LPJ) joins MS-Perspektive to discuss stem cells, myelin repair, and the future of treatment for progressive MS. 🔗 ms-perspektive.de/en/129-luc… #MSResearch #RESTOREConsortium #ProgressiveMS

Hope for Myelin Repair: Stem Cells & Progressive MS

Can neural stem cells support myelin repair and slow progression in MS? Dr. Luca Peruzzotti Jametti shares research, safety, and timelines.

ms-perspektive.de
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Applications are invited for a highly organised and proactive Project Coordinator to provide dedicated support to the @Pluchino (pluchinolab.org) and @Dr_LPJ (LPJLab.org) teams at the University of Cambridge jobrxiv.org/job/university-o…
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Glad to see our work featuring in the #Lancet #Neurology Round-Up focused on #MultipleSclerosis in 2024: evolving evidence and new hopes! Fight MS! thelancet.com/journals/laneu…
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Single-nucleus RNA sequencing of human periventricular white matter in vascular #dementia biorxiv.org/content/10.1101/…

Single-nucleus RNA sequencing of human periventricular white matter in vascular dementia

Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral...

biorxiv.org
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The danger theory of immunity revisited nature.com/articles/s41577-0…

The danger theory of immunity revisited

Nature Reviews Immunology - Thirty years ago, Polly Matzinger introduced the ‘danger theory of immunity’, which proposed that danger and damage have a decisive role in immune responses....

nature.com
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Giancarlo Comi, morto a 76 anni il luminare della neurologia: era uno dei massimi esperti italiani di sclerosi multipla milano.corriere.it/notizie/c…

Giancarlo Comi, morto a 76 anni il luminare della neurologia: era uno dei massimi esperti italiani...

Il professore onorario dell'università del San Raffaele aveva avuto un malore giovedì scorso mentre stava parlando a un convegno. Il collega Burioni:«Lascia un vuoto che ora appare incolmabile»

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Professor Giancarlo Comi was a visionary leader in multiple sclerosis research, leaving an indelible mark on the field. His legacy lives on through his groundbreaking work and unwavering dedication to those affected by #multiplesclerosis. aism.it/memory-professor-gia… @aism_nazionale
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Comprehensive phenotypic assessment of nonsense mutations in #mitochondria ND5 in mice nature.com/articles/s12276-0…

Comprehensive phenotypic assessment of nonsense mutations in mitochondrial ND5 in mice

Experimental & Molecular Medicine - Mitochondria, often referred to as cell's powerhouses, are essential for energy production and health. In this study, researchers used recently developed...

nature.com
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The massed-spaced learning effect in non-neural human cells nature.com/articles/s41467-0…

The massed-spaced learning effect in non-neural human cells

Nature Communications - When learning is spaced in time, memory is enhanced, but so far this was only observed in neural systems. Here, the authors show that non-neural cells, including kidney...

nature.com
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L Peruzzotti-Jametti retweeted
nature
@Nature9 Nov 2024
A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussion about the ethics of self-experimentation go.nature.com/3NXqzEq
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Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli nature.com/articles/s41598-0…
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Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks nature.com/articles/s41467-0…

Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks

Nature Communications - Emerging genome editing tools have been reported to possess threats to genome stability, while their impact on mitochondrial DNA (mtDNA) remains unknown. Here, authors...

nature.com
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Interaction between subventricular zone #microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic #stroke nature.com/articles/s41467-0…

Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic...

Nature Communications - There is a limited endogenous subventricular zone (SVZ)-derived neurogenic response for brain repair. Here, the authors report that cortical stroke-evoked environmental...

nature.com
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In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons nature.com/articles/s41467-0…

In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons

Nature Communications - The mechanisms underlying microglia-neuron interactions are incompletely understood. Utilizing in vivo multimodal microscopy and optical clearing technology, here the...

nature.com
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Ruben QC@RubenQC_Lab27 Sep 2024
Don't miss this opportunity to learn from Luca Peruzzotti @Dr_LPJ at @InstitutoCajal @CSIC! 🧠 🔬
Centro de Neurociencias Cajal - CSIC@CNCajal_CSIC26 Sep 2024
El próximo Viernes, 4 de Octubre, a las 12:30h. en la Sala Washington Buño del #InstitutoCajal, seminario del Dr. Luca Peruzzotti-Jametti @Cambridge_Uni, bajo el título: "Targeting microglial mitochondrial metabolism to halt chronic central nervous system inflammation".
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El próximo Viernes, 4 de Octubre, a las 12:30h. en la Sala Washington Buño del #InstitutoCajal, seminario del Dr. Luca Peruzzotti-Jametti @Cambridge_Uni, bajo el título: "Targeting microglial mitochondrial metabolism to halt chronic central nervous system inflammation".
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Tolebrutinib demonstrated a 31% delay in time to onset of confirmed disability progression in non-relapsing secondary progressive multiple sclerosis phase 3 study sanofi.com/en/media-room/pre…

Press Release: Tolebrutinib demonstrated a 31% delay in time to onset of confirmed disability...

Tolebrutinib demonstrated a 31% delay in time to onset of confirmed disability progression in non-relapsing secondary progressive multiple sclerosis phase 3 study Data presented at ECTRIMS...

sanofi.com
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FDA approves Ocrevus Zunovo, which has the same mechanism of action as Ocrevus, but is available as an HCP-administered SC injection rather than intravenous (IV, into a vein) infusion. nationalmssociety.org/news-a…

FDA Approves Ocrevus Zunovo for MS | National MS Society

The FDA has approved Ocrevus Zunovo, a twice-a-year HCP-administered subcutaneous injectable DMT for the treatment of MS. Learn more about this medication.

nationalmssociety.org
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Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients onlinelibrary.wiley.com/doi/…

Unexpected Low Rate of Amyloid‐β Pathology in Multiple Sclerosis Patients

The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that...

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