Scientist. Mother. Captain's wife. Loves numbers. https://xitter.cf/t.co/UZXyuOFvD8

Amsterdam, The Netherlands
Joined May 2015
The largest GWAS for Alzheimer's disease is now out 👉109,479 cases, 74,141 proxy cases, 2,131,799 controls, 499,708 proxy controls 👉improved SNP-based heritability: 5% in previous studies --> 19% 👉127 loci, 48 novel with enrichment in microglia & neurons
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#ctglab is hiring! We have #vacancies! 2 PhD and 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇 werkenbij.vu.nl/vacatures/tw… werkenbij.vu.nl/vacatures/po… werkenbij.vu.nl/vacatures/po…
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Incredibly proud to see our latest work out in Nature Genetics: nature.com/articles/s41588-0… Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥 Special thanks to @DPosthu Full thread describing findings below!
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New biotech launch (@TraceNeuro) targeting UNC13A in ALS with an ASO is another example of human genetics informing drug development🧬 UNC13A was among the first GWAS hits discovered for ALS nature.com/articles/ng.442 businesswire.com/news/home/2…
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Thanks for joining us 🤩
Something that makes me feel I am in Istanbul🇹🇷2 Thanks @itumbgclub for the amazing time in Istanbul!!
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Had an absolute blast at #wcpg2024 in Singapore ! ✨🥳 Thank you to everyone who came to check out my poster and for the nice discussions And also the 🕺🎤🎵
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Had a great time presenting my poster at #wcpg2024! Thanks for all the insightful discussions 🥳🧬
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I stole this from a tweet I saw a day or two ago, but now can’t find. Anyway, it’s on my office door now.
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Day one of the #WCPG2024 and so many exciting updates from the #PGC working groups.
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The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI. I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm. You can find the first lecture here: youtu.be/1zZSPeKGRzw and more will be coming in the playlist below. Fall 2024: youtube.com/playlist?list=PL… Spring 2021: youtube.com/watch?v=0jWOZoTs… Fall 2020: youtube.com/watch?v=CTPs5HEL… #CompBio #DeepLearning #MachineLearning #Genomics #Therapeutics #RepresenationLearning #Chemistry #ProteinFolding #ClinicalRecords #SingleCell
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Important work on dopaminergic system development just published in Nature Communications. Congrats to @oxana_garritsen and @JeroenPasterk!
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To live is to suffer; to survive is to find some meaning in the suffering.
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Polygenic risk scores (PRS) can aid in understanding why some individuals are more at risk of obesity. Clinical geneticist Philip Jansen @phi_jan and colleagues discuss potential applications of PRS in obesity research, out now in Obesity Reviews: onlinelibrary.wiley.com/doi/…
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And the winner is ... Bernardo Maciel who last week won the Poster Prize at the Dutch Neuroscience Meeting. Congratulations and well deserved!! @VUamsterdam
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Identifying drug targets for schizophrenia through gene prioritization medrxiv.org/cgi/content/shor… #medRxiv
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An atlas of the early development of the #brain is presented in a study in @Nature. The atlas can e.g. be used to find out what went wrong in the development of brain tumors in children and also to find new treatments. Research by @slinnarsson et al. news.ki.se/early-genetic-dev…
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Danielle retweeted
Astrophysicist and Nobel laureate Subrahmanyan Chandrasekhar used to travel 80 kilometers every week from the Yerkes Observatory to the University of Chicago, where he taught a course attended by only two students. When asked why he spent his time this way, the professor replied that they were very good students. In 1957, Lee Tsung-Dao and Yang Chen-Ning were awarded the Nobel Prize in Physics. The course taught by Subrahmanyan Chandrasekhar became the only course in history where all its attendees received a Nobel Prize.
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nature
@Nature12 Dec 2023
Nature research paper: Cell type directed design of synthetic enhancers go.nature.com/3RkatGn
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