Danielle retweeted
The largest GWAS for Alzheimer's disease is now out
👉109,479 cases, 74,141 proxy cases, 2,131,799 controls, 499,708 proxy controls
👉improved SNP-based heritability: 5% in previous studies --> 19%
👉127 loci, 48 novel with enrichment in microglia & neurons
Danielle retweeted
Our new preprint on "The genetic landscape of heterogeneity in human functional brain connectivity" is available on medRxiv. Check it out! @MJ_Schipper, Christiaan de Leeuw, @cato_romero, @khelwegen, @DPosthu, Jeanne Savage and Martijn van den Heuvel.
medrxiv.org/content/10.1101/…
Danielle retweeted
#ctglab is hiring! We have #vacancies! 2 PhD and 2 postdoc positions, in #statistical #genetics and/or #bioinformatics - if you like GWAS, method development and linking with biology - check these out 👇
werkenbij.vu.nl/vacatures/tw…
werkenbij.vu.nl/vacatures/po…
werkenbij.vu.nl/vacatures/po…
Danielle retweeted
Incredibly proud to see our latest work out in Nature Genetics: nature.com/articles/s41588-0…
Here we share our FLAMES framework, which predicts the effector genes in GWAS loci with state-of-the-art precision🔥
Special thanks to @DPosthu
Full thread describing findings below!
Danielle retweeted
New biotech launch (@TraceNeuro) targeting UNC13A in ALS with an ASO is another example of human genetics informing drug development🧬
UNC13A was among the first GWAS hits discovered for ALS nature.com/articles/ng.442
businesswire.com/news/home/2…
Danielle retweeted
Thanks for joining us 🤩
Something that makes me feel I am in Istanbul🇹🇷2
Thanks @itumbgclub for the amazing time in Istanbul!!
Danielle retweeted
Had an absolute blast at #wcpg2024 in Singapore ! ✨🥳 Thank you to everyone who came to check out my poster and for the nice discussions
And also the 🕺🎤🎵
Danielle retweeted
Had a great time presenting my poster at #wcpg2024! Thanks for all the insightful discussions 🥳🧬
Danielle retweeted
I stole this from a tweet I saw a day or two ago, but now can’t find.
Anyway, it’s on my office door now.
Danielle retweeted
Grad to see our Comment about inconsistent embryo selection across PRS methods is out in @NatureHumBehav! nature.com/articles/s41562-0… Thanks again to the great collab with specialists for genetics/ELSI @akiyama_mst, @kazutokato6, @ogishima, @qsonehara, @go_kenbo, @okada_yukinori
Danielle retweeted
The field of #ComputationalBiology has changed dramatically in the last few years with #GenerativeAI.
I'm excited to be recording my lectures again this year, and to be teaching with the awesome @EjAlm.
You can find the first lecture here: youtu.be/1zZSPeKGRzw
and more will be coming in the playlist below.
Fall 2024: youtube.com/playlist?list=PL…
Spring 2021: youtube.com/watch?v=0jWOZoTs…
Fall 2020: youtube.com/watch?v=CTPs5HEL…
#CompBio #DeepLearning #MachineLearning #Genomics #Therapeutics #RepresenationLearning #Chemistry #ProteinFolding #ClinicalRecords #SingleCell
Today was my last lecture for @MIT #ComputationalBiology: #Genomes, #Networks, #Evolution, #Health. I recorded each and immediately posted online here: youtube.com/playlist?list=PL…
Please do share, and let me know which topics need more explanations, clarifications, and corrections!
Danielle retweeted
Important work on dopaminergic system development just published in Nature Communications. Congrats to @oxana_garritsen and @JeroenPasterk!
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Danielle retweeted
Polygenic risk scores (PRS) can aid in understanding why some individuals are more at risk of obesity. Clinical geneticist Philip Jansen @phi_jan and colleagues discuss potential applications of PRS in obesity research, out now in Obesity Reviews: onlinelibrary.wiley.com/doi/…
Danielle retweeted
And the winner is ... Bernardo Maciel who last week won the Poster Prize at the Dutch Neuroscience Meeting. Congratulations and well deserved!! @VUamsterdam
Danielle retweeted
Identifying drug targets for schizophrenia through gene prioritization medrxiv.org/cgi/content/shor… #medRxiv
Danielle retweeted
An atlas of the early development of the #brain is presented in a study in @Nature. The atlas can e.g. be used to find out what went wrong in the development of brain tumors in children and also to find new treatments. Research by @slinnarsson et al.
news.ki.se/early-genetic-dev…
Danielle retweeted
Astrophysicist and Nobel laureate Subrahmanyan Chandrasekhar used to travel 80 kilometers every week from the Yerkes Observatory to the University of Chicago, where he taught a course attended by only two students. When asked why he spent his time this way, the professor replied that they were very good students.
In 1957, Lee Tsung-Dao and Yang Chen-Ning were awarded the Nobel Prize in Physics. The course taught by Subrahmanyan Chandrasekhar became the only course in history where all its attendees received a Nobel Prize.
Danielle retweeted

nature@Nature12 Dec 2023
United Kingdom!
United KingdomConnected via United Kingdom App StoreLocation may be affected by a proxy or VPN.Account-level information, not a live location or per-post device.
Nature research paper: Cell type directed design of synthetic enhancers go.nature.com/3RkatGn
































